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311篇 您的检索式：作者名="OLIVER HART"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	One Share-one Vote and the Market for Corporate Control显示文摘	Sanford Olive Hart	1988	Journal of Financial Economics1988，20，：	1
3	The Costs and Benefits of Ownership:A Theory of Vertical and Lateral Integration显示文摘	Grossman Sanford and Oliver Hart	1986	Journal of Political Economy1986，94，：	1
4	The costs and benefits of own- ership: A theory of vertical and lateral integration 显示文摘	Grossman Sanford Oliver Hart	1986	Journal of Political Economy1986，94，4：	1
5	Property Rights and the Nature of the Firm 显示文摘	Oliver D Hart John Moore	1990	Joumal of Political Economy1990，98，6：	1
6	Property Rights and Na- ture of the Firm显示文摘	Hart Oliver and John Moore	1990	Journal of Political Economy1990，，98：	1
7	Contracts as Reference Points 显示文摘	OLIVER HART JOHN MOORE	2008	Quarterly Journal of Economics2008，123，1：	1
8	Property rights and the nature of the firm 显示文摘	Oliver Hart John Moore	1990	Journal of Political Economy1990，98，6：	1
9	The Cost and Benefits of Ownership:A Theory of Vertical and Lateral Integration 显示文摘	] Sanford J Grossman Oliver D Hart	1986	The Journal of Political Economy1986，94，4：	1
10	Theory of Debt Based on the Inalienability of Human Capital 显示文摘	Hart Oliver and John Moore	1994	Quarterly Journal of Economics1994，，109：	1
11	On the profitability of speculation显示文摘	Hart Oliver D	1977	Quarterly Journal of Economics1977，91，4：	1
12	The costs and benefits of ownership: a theory of vertical and lateral integration 显示文摘	SANFORD GROSSMAN OLIVER HART	1986	Journal of Political Economy1986，94，4：	1
13	The Costs and Benefits of Owner-ship:A Theory of Vertical and Lateral Integration显示文摘	Grossman Sanford Oliver Hart	1986	Journal ofPolitical Economy1986，944，：	1
14	The costs and benefits of ownership: A theory of lateral and vertical integration显示文摘	Sanford and Hart Oliver	1986	Journal of Political Economy1986，94，：	1
15	Incomplete contracts and renegotiation 显示文摘	OLIVER HART JOHN MOORE	1988	Econometrica1988，56，4：	1
16	Property Rights and Nature of the Firm显示文摘	Oliver Hart John Moore	1990	Journal of Political Economy1990，986，：	1
17	An Economist's Perspective on the Theory of the Firm 显示文摘	Hart Oliver	1989	Columbia Law Review1989，89，7：	1
18	Property rights and the nature of the firm 显示文摘	Oliver and Moore John	1990	Journal of Political Economy1990，98，：	1
19	The proper scope of government显示文摘	Hart Oliver Andrei Shleifer Robert Vishny	1997	Quarterly Journal of Economics1997，112，4：	1
20	Property rights and the nature of the firm显示文摘	Hart Oliver John Moore	1990	Journal of Political Economy1990，，98：	1

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