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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Bacterial microcosms obey Taylor’s law:effects of abiotic and biotic stress and genetics on mean and variance of population density显示文摘Introduction:According to the empirical regularity called Taylor’s law,the variance of population density in samples of populations is a power of the mean population density.The exponent is often between 1 and 2.Our experiments investigated how genetics,evolution,and environment shape Taylor’s law.Methods:Genetically different strains(wild type and hypermutator)of the bacterium Pseudomonas fluorescens evolved and were assayed under different environmental conditions(with and without antibiotic rifampicin and bacteriophage SBW252,separately and in combination).Results:Experimental treatments altered the exponent b,but not the power law form,of the relation between variance and mean population density.Bacterial populations treated only with rifampicin had a narrow range of mean population densities and exponent b=5.43.Populations exposed to rifampicin plus phage had b=1.51.In ancestral,control,and phage-exposed populations,mean abundance varied widely and b was not significantly different from 2.Evolutionary factors(mutation rate,selection)and ecological factors(abiotic,biotic)jointly influenced b.Conclusions:Taylor’s power law relationship accurately and robustly described variance as a function of mean population density,with overall exponent b=1.89.These and other experiments with different factors acting on bacterial population size support the relevance of models that predict‘universal’patterns of fluctuation scaling. | Oliver Kaltz Patricia Escobar-Páramo Michael E Hochberg Joel E Cohen | 2012 | Ecological Processes2012，1，1： | 3 |
| 3 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 4 | Pharmacokinetics and tolerability of gemifloxacin (SB- 265805) after administration of single oral doses to healthy volunteers 显示文摘 | Allen A Bygate E Oliver S | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 5 | CDL--A component description language for reuse 显示文摘 | Huw E Oliver | 1993 | International Journal of Software Engineering and Knowledge Engineering1993，3，4： | 1 |
| 6 | The relative effects of deformation and thermal advection on fluid pathways in basin-related mineralization显示文摘 | Mclellan J G Oliver N H S Hobbs B E | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 7 | Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘 | Talbot M T Oliver C C Gaffney P E | 1990 | ASHARE Transactions1990，9，： | 1 |
| 8 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 9 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 10 | In-situ neutron diffraction of titanium silicide TisSi3 during self-propagating high-temperature synthesis显示文摘 | Riley D P Oliver C P Kisi E H | 2006 | Intermetallic2006，，14： | 1 |
| 11 | The impact of technology invest- ments on a firm's production efficiency, product quality, and pro- ductivity 显示文摘 | THATCHER M E OLIVER J R | 2001 | Journal of Management Information Systems2001，18，2： | 1 |
| 12 | Cytotoxicity, mutagenicity and DNA damage by hoechst 33342显示文摘 | DURAND R E OLIVE P L | 1982 | J Histochem Cytochem1982，30，2： | 1 |
| 13 | The isolation from wheat germ oil of an alcohol,alpha-tocopherol,having the properties of vitamin E nutrition显示文摘 | Herbert M E Oliver H E Gladys A E | 1936 | The Journal of Biological Chemistry1936，113，： | 1 |
| 14 | Williarnson:The Modern Corporation:Origins,Evolution,Attributes显示文摘 | Oliver E | 1981 | Journal of Economic Literature1981，，19： | 1 |
| 15 | Breaking a para digm : Male produced aggregation pheromone for Colorado pota to beetle显示文摘 | Dickens J C Oliver J E Hollister B | 2002 | J Exp Biol2002，205，： | 1 |
| 16 | Consumer Perceptions of Interpersonal Equity and Satisfaction in Transactions : A Field Survey Approach 显示文摘 | OLIVER R L SWAN J E | 1989 | Jour- nal of Marketing1989，，4： | 1 |
| 17 | PIXE Analysis of Zn Enzymes显示文摘 | Solis C Oliver A Andrade E | 1999 | Nucl Instrum Meth B1999，150，： | 1 |
| 18 | Management ecosystems for forest health:an approach and the effects on uses and values 显示文摘 | Oliver C D Ferguson D E Harvey A E | 1994 | Journal of Sustainable Forestry1994，2，1： | 1 |
| 19 | Loss of the p16/MTS1 tumor suppressor gene causes E2F mediated deregula- tion of essential enzymes of the DNA precursor metabolism显示文摘 | Hengstschlager M Oliver P Hengstshlager-Ottnad E | 1996 | DNA Cell Biol1996，15，1： | 1 |
| 20 | Comparative Economic Organization:the Analysis of Discrete Structural Alternatives显示文摘 | OLIVER E WILLIAMSON | 1991 | Administrative Science Quarterly1991，36，2： | 1 |
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