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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Extraction precision of sieving and brine flotation for removal of wheat midge,Sitodiplosis mosellana(Diptera;Cecidomyiidae),cocoons and larvae from soil显示文摘 | Doane J F Olfert O O Mukerji M K | 1987 | J Econ Entomol1987，80，： | 1 |
| 3 | Does gender affect human pulmonary gas exchange during exercise显示文摘 | Olfert IM Balouch J Kleinsasser A | 2004 | J Physiol2004，557，2： | 1 |
| 4 | Development of sampling designs for egg and larval populations of the wheat midge,Sitodiplosis mosellana(Diptera;Cecidomyiidae),in wheat显示文摘 | Mukerji M K Olfert O O Doane J F | 1988 | The Canadian Entomo Logist1988，120，6： | 1 |
| 5 | The effective density and fractal dimension of particles emitted from a light - duty diesel ve- hicle with a diesel oxidation catalyst 显示文摘 | Olfert J S Symonds J P R Collings N | 2007 | Journal of Aerosol Sci- ence2007，38，26： | 1 |
| 6 | Canadian inter-laboratory organically bound tritium(OBT)analysis exercise显示文摘 | KIM S B OLFERT J BAGLAN N | 2015 | J Environ Radioact2015，150，： | 1 |
| 7 | Relationship between infestation levels and yield loss caused by wheat midge,Sitodiploosis mosellana(Gehin) (Diptera:Cecidomyiidae),in spring wheat in Saskatchewan显示文摘 | Olfert O O Mukerji M K Doane J F | 1985 | The Canadian Entomologist1985，117，： | 1 |
| 8 | Distribution and seasonal abundance of Sitodiplosis mosellana(Dipter , Cecidomyiidae)in spring wheat显示文摘 | Lamb R J Wise I L OLfert O O | 1999 | The Canadian Entomologist1999，131，： | 1 |
| 9 | Relationship be- tween infestation levels and yield loss caused by wheat midge, Sitodiplosis mosellana (Gehin) ( Diptera: Ce- cidomyiidae) ,in spring wheat in Saskatchewanr显示文摘 | Olfert O O Mukerji M K Doane J F | 1985 | The Canadian Entomologist1985，117，： | 1 |
| 10 | The Effective Density and Fractal Dimension of Particles Emitted From a Light-duty Die- sel Vehicle with a Diesel Oxidation Catalyst 显示文摘 | Olfert J S Symonds J P R Collings N | 2007 | Journal of Aero- sol Science2007，38，1： | 1 |
| 11 | Distribution and seasonal abundance of Sitodiplosis mosellana (Diptera:Cecidomyiidae) in spring wheat显示文摘 | Lamb R J Wise IL Olfert OO | | 0，，： | 1 |
| 12 | Development of sampling designs for egg and larval population of the wheat midge, Sitodiplosismosellana (G6hin) (Diptera: Cecidomyiidae) in wheat 显示文摘 | Mukerji M K Olfert O O Doane J F | 1988 | The Canada Entomologist1988，120，： | 1 |
| 13 | Seasonal development of wheat midge, (Diptera : Cecidomyiidae), in Saskatchewan, Canada 显示文摘 | DOANE J F OLFERT O | 2008 | Crop Protection2008，27，： | 1 |
| 14 | Seasonal development of wheat midge,Sitodiplosis mosellana (Gehin) (Diptera : Cecidomyiidae), in Saskatchewan 显示文摘 | Doane J F Olfert O | 2008 | Crop Protection2008，27，6： | 1 |
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