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| 1 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 2 | Possible improvements in the action of some rust converters显示文摘 | C.A Barrero L.M Ocampo C.E Arroyave | 2001 | Corrosion Science2001，，6： | 2 |
| 3 | Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility显示文摘Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DENV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (DENV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti. | Paola A. Caicedo Idalba Mildred Serrato Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo | 2019 | Insect Science2019，26，4： | 2 |
| 4 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 5 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 6 | Genetic relationships among Neisseria gonorrhoeae semvars analysed by multilocus enzyme electrophoresis 显示文摘 | Poh CL Ocampo JC Loh GK | 1992 | Epidemiol Infect1992，108，1： | 1 |
| 7 | Fibrin glue sealing of pancreatic injuries,resections,and anastomoses显示文摘 | Kram HB Clark SR Ocampo HP | 1991 | Am J Surg1991，161，4： | 1 |
| 8 | DICOM gray-scale standard display fimction: clinical diagnostic accuracy of chest radiography in medical-grade gray-scale and cousumer grade color displays显示文摘 | Salazar AJ Aguirre DA Ocampo J et aI | 2014 | AJR Am J R oentgenol2014，202，6： | 1 |
| 9 | 查看详情显示文摘 | Louis B Ocampo F Yun H S Twssonnier J P Pereira M M | | 0，，： | 1 |
| 10 | Neuroleptic malig- nant syndrome in Mexico显示文摘 | Montoya A Ocampo M Torres -Ruiz A | 2003 | Can J Clin Pharmacol2003，10，3： | 1 |
| 11 | Neuroleptic malignant syndrome in Mexico 显示文摘 | Montoya A Ocampo M Torres-Ruiz A | 2003 | Can J Clin Pharmacol2003，10，3： | 1 |
| 12 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 13 | P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease 显示文摘 | Salehi A Ocampo M Verhaagen J | 2000 | Exp Neurol2000，161，1： | 1 |
| 14 | The local anesthetic activity of Aconitum alkaloids can be explained by their structural properties: a QSAR analysis 显示文摘 | Bello - Ramirez AM Nava - Ocampo AA | 2004 | Fund ClinPhamlacol2004，18，2： | 1 |
| 15 | Use of low doses of clenbuterol to reduce incidence of ascites syndrome in broilers显示文摘 | Ocampo L Cortez U Sumano H | 1998 | Poult Sci1998，77，9： | 1 |
| 16 | An experimental study on gasification of colombian coal in fluidised bed显示文摘 | Ocampo A Arenas E Chejne F | 2003 | Fuel2003，82，2： | 1 |
| 17 | Performance of rust converter based in phosphoric and tannic acids显示文摘 | Ocampo L M Margarit I C P Mattos O R | 2004 | Corrosion Science2004，46，6： | 1 |
| 18 | Revisiting the surgical creation of volume load by aorto-caval shunt in rats显示文摘 | Ocampo C Ingram P Ilbawi M | 2003 | Mol Cell Biochem2003，251，12： | 1 |
| 19 | Low-Thrust Variable-Specific-Impulse Transfers and Guidance to Unstable Periodic Orbits显示文摘 | Senent Juan Ocampo Cesar Capella Antonio | 2005 | Journal of Guidance Control and Dynamics2005，28，2： | 1 |
| 20 | Pharmacokinetics of an injectable long-acting parenteral formulation of doxycycline hyclate in pigs显示文摘 | Gutierrez L Ocampo L Espinosa F | 2014 | J Vet Pharmacol Ther2014，37，1： | 1 |
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