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| 1 | Noise-induced nitrotyrosine increase and outer hair cell death in guinea pig cochlea显示文摘 | HAN Wei-ju SHI Xiao-rui Alfred Nuttall | 2013 | Chinese Medical Journal2013，，15： | 12 |
| 2 | 噪声刺激致豚鼠外毛细胞凋亡时半胱氨酸天冬氨酸蛋白酶3激活和凋亡诱导因子转移显示文摘目的探讨噪声损伤后豚鼠外毛细胞发生凋亡的通路及其机制。方法分离解剖对照组(12只)和噪声暴露组(12只)豚鼠耳蜗,利用免疫荧光抗体和免疫荧光染料,分别染色细胞核、线粒体、凋亡诱导因子(apoptosis inducing factor,AIF)和半胱氨酸天冬氨酸蛋白酶3(Caspase 3),按表面制备法行耳蜗铺片,观察凋亡和坏死毛细胞内的荧光信号。结果对照组正常耳蜗毛细胞内没有激活的 Caspase 3,AIF 分布在毛细胞的线粒体内。实验组动物暴露于声压级120 dB 的白噪声环境中每天4 h,连续2 d 后,耳蜗外毛细胞出现死亡,表现为坏死和凋亡两种方式,但以凋亡为主。在凋亡的外毛细胞中,Caspase 3被激活,AIF 从线粒体转移到细胞核中;而在坏死的外毛细胞中,没有 Caspase3的激活,只有 AIF 自线粒体向细胞核的转移。结论噪声损伤后耳蜗外毛细胞的凋亡以 Caspase 依赖型的通路为主;线粒体释放的 AIF 在外毛细胞死亡通路中起重要作用。 | 韩维举 史晓瑞 Alfred Nuttall | 2007 | 中华耳鼻咽喉头颈外科杂志2007，42，7： | 7 |
| 3 | 噪声损伤引起耳蜗外毛细胞凋亡时细胞核内单链DNA的产生及EndoG的转移显示文摘目的观察噪声损伤后耳蜗外毛细胞内单链DNA和EndoG的变化,探讨耳蜗外毛细胞的死亡机制。方法豚鼠随机分为噪声暴露组、MNNG耳蜗灌流组和对照组(每组各12只);小鼠随机分为噪声暴露组和对照组(每组12只)。分离解剖耳蜗后,用碘化丙啶(PI)染色细胞核、Pholloidin染色F-actin,免疫荧光抗体分别染色单链DNA(ssDNA)、核酸内切酶G(Endonuclease G EndoG)和凋亡诱导因子(Apoptosis inducing factors,AIF),制备耳蜗铺片,激光共聚焦显微镜下观察凋亡和坏死毛细胞内的荧光信号变化。结果(1)暴露于120dBSPL的白噪声环境中每天4小时,连续2天后引起豚鼠和小鼠耳蜗外毛细胞凋亡时,其细胞核内产生ssDNA,而在正常细胞内没有三ssDNA;(2)在正常情况下,EndoG分布于耳蜗毛细胞的细胞核外,在暴露于上述噪声后发生凋亡和坏死的豚鼠耳蜗外毛细胞中,EndoG从细胞核外转移到细胞核内,细胞核中的EndoG显著增加;(3)豚鼠耳蜗外淋巴灌流烷化剂MNNG后发生耳蜗外毛细胞凋亡和坏死,在凋亡和坏死的耳蜗外毛细胞中,AIF自线粒体转移到细胞核,其变化与噪声损伤引起耳蜗外毛细胞凋亡和坏死时一致。结论噪声刺激或烷化剂MNNG灌流后,造成耳蜗外毛细胞DNA损伤,产生ssDNA,引起AIF和EndoG自线粒体释放,激活Caspase-3,AIF和EndoG进一步向细胞核转移,最终使细胞核内的DNA降解,导致耳蜗毛细胞的死亡。 | 韩维举 史晓瑞 Alfred Nuttall | 2008 | 中华耳科学杂志2008，6，2： | 6 |
| 4 | Plasma Tranexamic Acid Concentrations During Cardiopulmonary Bypass显示文摘 | Bridget K. Fiechtner Gregory A. Nuttall Michael E. Johnson Yue Dong Nuntiya Sujirattanawimol William C. Oliver Rajbir S. Sarpal Lance J. Oyen Mark H. Ereth | 2001 | Anesthesia and Analgesia2001，，5： | 2 |
| 5 | Electromotile hearing:evidence from basilar membrane motion and otoacoustic emissions显示文摘 | Nuttall AL Ran T | | 0，，： | 2 |
| 6 | Ferrimagnetic mixed-valency and mixed-metal tris(oxalato)iron( Ⅲ ) compounds: synthesis, structure, and magnetism显示文摘 | Mathoniere C Nuttall C J Carling S G | 1996 | Inorng Chem1996，35，5： | 1 |
| 7 | New geographical approaches to control of some parasitic zoonoses 显示文摘 | Mort KE Nuttall I Desjex P | 1995 | WHO Bull1995，73，： | 1 |
| 8 | Cardiovascular events and correlates in Veterans Affairs Diabetes Feasibility trial显示文摘 | Abraira C Colwell J Nuttall F | 1997 | Archives of internal Medicine1997，157，： | 1 |
| 9 | Viral comamination of bovine foetal serum and cell cultures 显示文摘 | Nuttall PA Luther PD Stott EJ | 1977 | Nature1977，266，5603： | 1 |
| 10 | Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis 显示文摘 | NUTTALL M E GIMBLE J M | 2000 | Bone2000，27，2： | 1 |
| 11 | Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis 显示文摘 | Bar-Or A Nuttall RK Duddy M | 2003 | Brain2003，126，12： | 1 |
| 12 | Efficacy of a simple introperative transfution algorithm for nonerythrocyte component utilization after cardiopulmonary bypass显示文摘 | Nuttall G Oliver W Santrach P et ai | 2001 | Anesthesiology2001，94，1： | 1 |
| 13 | An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization显示文摘 | Weaver A Goncalves da Silva A Nuttall RK | 2005 | FASEB2005，19，： | 1 |
| 14 | Basilar membrane vibration in the basal turn of the sensitive gerbil cochlea 显示文摘 | REN T Y NUTTALL A L | 2001 | Hearing Research2001，151，1： | 1 |
| 15 | Remediation of U ( Ⅵ ) - contaminated water using zero - valent iron 显示文摘 | Abdelouas A Lutze W Nuttall E | 1999 | Earth & Planetary Sciences1999，328，： | 1 |
| 16 | Some windows with very good sidelobe be- havior显示文摘 | NUTTALL A H | 1981 | IEEE Transactions on Acoustics Speech and Signal Processing1981，29，： | 1 |
| 17 | Effects of carbon monoxide on cochlear electrophysiology and blood flow 显示文摘 | Fechter LD Thorne PR Nuttall AL | 1987 | Hear Res1987，27，： | 1 |
| 18 | Estimation of the magnitu de -squared coherebce function via overlapped fast Fourier transform processing 显示文摘 | Carter GC Knapp CH and Nuttall AH | | IEEE-trans Audio and Electroacoustics0，21，4： | 1 |
| 19 | High-synchrony cochlear compoundaction potentials evoked by rising frequency-swept tone bursts显示文摘 | Shore S E Nuttall A L | 1985 | J Acoust Sue Am1985，78，4： | 1 |
| 20 | A cardiac prevention and rehabilitation programme for all patients at first presentation with coronary artery disease显示文摘 | Fox K F Nuttall M Wood D A | | 0，，05： | 1 |
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