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| 1 | Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice显示文摘Objective:To explore the immunomodulatory properties of 80% ethanol extract and butanol fraction of Gentiana olivieri(G. olivieri) Griseb on Balb/C mice.Methods:The study was performed with basic models of immunomodulation such as the humoral antibody response(hemoglutination antibody titres), cell mediated immune response(delayed type hypersensitivity and in vivocarbon clearance or phagocytosis). Ethanol(80%) extract of flowering aerial parts of G.olivieriand its butanol fraction were administered p.o.(orally) to the mice. Levamisole, 2.5 mg/kg was used as standard drug.Results:There was a potentiation of immune response to sheep red blood cells by cellular and humoral mediated mechanisms comparable to levamisole(2.5 mg/kg) by both 80% ethanol extract and the butanol fraction at doses of 50-200 mg/kg in male Balb/C mice. Both significantly(P<0.01) potentiated the humoral immune response in cyclophosphamide(250 mg/kg)immunosupressed mice at 100 and 200 mg/kg of each extract and fraction as compared to control.The potentiation of delayed type hypersensitivity response was statistically significant(P<0.01) at200 mg/kg of ethanol extract and 100, 200 mg/kg of butanol fraction as compared to control. The phagocytosis was significant at 200 mg/kg with butanol fraction ofG. olivieri.Conclusions:The results reveal the immunostimulant effects of plantG. olivieriin mice by acting through cellular and humoral immunity in experimental models of immunity in mice. Butanol fraction is the most effective at a dose level of 200 mg/kg. | Satnam Singh Yadav CPS Malleshappa N Noolvi | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 2 | Benzothiazoles:search for anticancer agents显示文摘 | NOOLVI M N PATEL H M KAUR M | 2012 | Eur J Med Chem2012，54，： | 1 |
| 3 | Synthesis and anti-tubercular activity of a series of 2 sulfonamido/triflu- oromethyl-6-substituted imidazo-E 2, 1-b 1, 3, 4-thiadi- azole derivatives显示文摘 | Gadad A K Noolvi M N Karpoormath R V | 2004 | Bioorganie - Medicinal Chemistry2004，12，56： | 1 |
| 4 | Enhanced degradation of melanoidin and caramel in biomethanated distillery spentwash by microorganisms isolated from mangroves显示文摘 | Nagaraj Naik Jagadeesh K S Noolvi M N | 2010 | Iranica Journal of Energy &Environment2010，1，4： | 1 |
| 5 | 2,6-Disubstituted imidazo[2,1- b ][1,3,4]thiadiazoles: Search for anticancer agents显示文摘 | Malleshappa N. Noolvi Harun M. Patel Sarita Kamboj Amandeep Kaur Vikas Mann | 2012 | European Journal of Medicinal Chemistry2012，，： | 1 |
| 6 | Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1- b ][1,3,4]-thiadiazole derivatives显示文摘 | Malleshappa N. Noolvi Harun M. Patel Navjot Singh Andanappa K. Gadad Swaranjit Singh Cameotra Arvind Badiger | 2011 | European Journal of Medicinal Chemistry2011，，9： | 1 |
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