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| 1 | Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice显示文摘Objective:To explore the immunomodulatory properties of 80% ethanol extract and butanol fraction of Gentiana olivieri(G. olivieri) Griseb on Balb/C mice.Methods:The study was performed with basic models of immunomodulation such as the humoral antibody response(hemoglutination antibody titres), cell mediated immune response(delayed type hypersensitivity and in vivocarbon clearance or phagocytosis). Ethanol(80%) extract of flowering aerial parts of G.olivieriand its butanol fraction were administered p.o.(orally) to the mice. Levamisole, 2.5 mg/kg was used as standard drug.Results:There was a potentiation of immune response to sheep red blood cells by cellular and humoral mediated mechanisms comparable to levamisole(2.5 mg/kg) by both 80% ethanol extract and the butanol fraction at doses of 50-200 mg/kg in male Balb/C mice. Both significantly(P<0.01) potentiated the humoral immune response in cyclophosphamide(250 mg/kg)immunosupressed mice at 100 and 200 mg/kg of each extract and fraction as compared to control.The potentiation of delayed type hypersensitivity response was statistically significant(P<0.01) at200 mg/kg of ethanol extract and 100, 200 mg/kg of butanol fraction as compared to control. The phagocytosis was significant at 200 mg/kg with butanol fraction ofG. olivieri.Conclusions:The results reveal the immunostimulant effects of plantG. olivieriin mice by acting through cellular and humoral immunity in experimental models of immunity in mice. Butanol fraction is the most effective at a dose level of 200 mg/kg. | Satnam Singh Yadav CPS Malleshappa N Noolvi | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 2 | 2,6- Disubstituted imidazo thiadiazoles : Search for anticancer agent 显示文摘 | Malleshappa N N Harun M P Sarita K | 2012 | European Journal of Medicinal Chemistry2012，56，： | 1 |
| 3 | A twogeneration reproductive toxicity study with curcumin,turmeric yellow, in Wistar rats 显示文摘 | Ganiger S Malleshappa HN Krishnappa H | 2007 | Food Chem Toxicol2007，45，1： | 1 |
| 4 | A two generation reproductive toxicity study with curcumin,turmeric yellow,in Wistar rata显示文摘 | Ganiger S Malleshappa HN Krishnappa H | 2007 | Food Chem Toxicol2007，145，1： | 1 |
| 5 | Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo E2, l-b] -thiadiazole derivatives 显示文摘 | Malleshappa N N Harun M P Singh N | 2011 | European Journal of Medicinal Chemistry2011，46，9： | 1 |
| 6 | Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives : Search for anticancer agent 显示文摘 | MALLESHAPPA N N HARUN M P VARUN B | 2011 | Eur J Med Chem2011，46，6： | 1 |
| 7 | A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats 显示文摘 | GANIGER S MALLESHAPPA H N KRISHNAPPA H | 2007 | Food Chem Toxieol2007，45，1： | 1 |
| 8 | Effective use of polymyxin B hemoperfusion in septic shock complicated by urosep- sis显示文摘 | Malleshappa P Ranganath R Chaudhari AP | 2011 | Indian J Nephrol2011，21，1： | 1 |
| 9 | 2,6-Disubstituted imidazo[2,1- b ][1,3,4]thiadiazoles: Search for anticancer agents显示文摘 | Malleshappa N. Noolvi Harun M. Patel Sarita Kamboj Amandeep Kaur Vikas Mann | 2012 | European Journal of Medicinal Chemistry2012，，： | 1 |
| 10 | Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1- b ][1,3,4]-thiadiazole derivatives显示文摘 | Malleshappa N. Noolvi Harun M. Patel Navjot Singh Andanappa K. Gadad Swaranjit Singh Cameotra Arvind Badiger | 2011 | European Journal of Medicinal Chemistry2011，，9： | 1 |
| 11 | Diverse clinical and histology presentation in Clq nephropathy 显示文摘 | Malleshappa P Vankalakunti M | 2013 | Nephrourol Mon2013，5，3： | 1 |
| 12 | Acute kidney injury following paraquat poi- soning in India显示文摘 | MALLESHAPPA P | 2013 | Iran J Kidney Dis2013，7，1： | 1 |
| 13 | Path analysis for seed yield in safflower 显示文摘 | Malleshappa C Goud J V Patil S S | 1989 | J Maharashtra Agric Univ1989，14，2： | 1 |
| 14 | Dextran sulfate sodium(DSS)-induced colitis in mice显示文摘 | Chassaing B Aitken J D Malleshappa M | 2014 | Curr Protoc Immunol2014，104，： | 1 |
| 15 | 2,6-Disub- stituted imidazo thiadiazoles : search for an-ticancer agent显示文摘 | Malleshappa N N Harun M P Sarita K | 2012 | Eur J Med Chem2012，56，： | 1 |
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