|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Role of zinc during hamster sperm capacitation显示文摘 | Andrews J C Nolan J P Hammerstedt R H | 1994 | Biology of Reproduction1994，51，： | 1 |
| 3 | Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6,11,16,and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women显示文摘 | Block SL Nolan T Sattler C | 2006 | Pediatrics2006，118，5： | 1 |
| 4 | Toward A nopheles transformation:Minos element activity in anopheline cells and embryos显示文摘 | CATFERUCCIA F NOLAN T BLASS C | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 5 | Widespread sexual disruption in wild fish 显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science and Technology1998，32，17： | 1 |
| 6 | Lipid mediators in inflammatory in obesity-related glomerulopathy显示文摘 | Nolan E O'Meara YM Godson C | 2013 | Nephrol Dial Transplant2013，55，3： | 1 |
| 7 | Epigenetics and gene expression 显示文摘 | Gibney E R Nolan C M | 2010 | Heredity2010，105，： | 1 |
| 8 | Post-cardiac arrest syndrome:epidemiology,pathophysiology,treatment,and prognostication a consensus statement from the international liaison committee on resuscitation显示文摘 | Neumar RW Nolan JP Adrie C | 2008 | Circulation2008，118，23： | 1 |
| 9 | Lead nephrotoxicity and associated disorders-biochemical-mechanisms 显示文摘 | Nolan C V | 1992 | Toxicology1992，，73： | 1 |
| 10 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science & Technology1998，32，17： | 1 |
| 11 | Effect of added dietary nitrate and elemental sulfur on wool growth and methane emission of Merino lambs 显示文摘 | Li L SILVEIRA C I NOLAN J V | 2013 | Animal Production Science2013，53，11： | 1 |
| 12 | Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age显示文摘 | MORALES A J NOLAN J J NELSON J C | 1994 | The Journal of Clinical Endocrinology & Metabolism1994，78，6： | 1 |
| 13 | A physiologically based pharmacokinetic and pharmacodynamic(PBPK/PD)model for the organophosphate insecticide chlorpyrifos in rats and humans显示文摘 | Timchalk C Nolan RJ Mendrala AL Dittenber DA Brzak KA Mattsson JL | 2002 | Toxicol Sci2002，66，1： | 1 |
| 14 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C | 1998 | Environmental Science and Technology1998，32，17： | 1 |
| 15 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R Bfighty G | 1998 | Environ Sci Technol1998，32，17： | 1 |
| 16 | The electronic structure of oxygen vacancy defects at the low index surfaces of ceria显示文摘 | Nolan M Parker S C Watson G W | 2005 | Surf Sci2005，595，： | 1 |
| 17 | Carry-over effects of early-life supplementary methionine on lymphoid organs and immune responses in egg-laying strain chickens 显示文摘 | K Deng C W Wong J V Nolan | 2007 | Animal Feed Science and Technology2007，134，： | 1 |
| 18 | The influence of microglia on the pathogenesis of Parkinson' s di-sease显示文摘 | LONG-SMITH C M SULLIVAN A M NOLAN Y M | 2009 | Progress in Neurobiology2009，89，3： | 1 |
| 19 | Factors regulating throughfall flux in a New Hampshire forested landscape 显示文摘 | Lovett G M Nolan S S Driscoll C T | 1996 | Canadian Journal of Forest Research1996，26，： | 1 |
| 20 | Risk of nitrate in groundwaters of the United States a national perspective 显示文摘 | Nolan B T Ruddy B C Hitt K J | 1997 | Environ Sci Technol1997，31，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员