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| 1 | Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet显示文摘We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol | N. NISHIZAWA S. SHIMANUKI H. FUJIHASHI H. WATANABE Y. FUDAMOTO AND T. NAGASAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, Sagae, Yamagata 991 Ka | 1996 | Biomedical and Environmental Sciences1996，9，2： | 24 |
| 2 | TRANSITION OF CONVECTIVE PATTERNS IN A RECTANGULAR CELL显示文摘In this paper our interest is focussed on the behavior in the transition of the Traveling Wave (TW) convective patterns along the nonlinear branch in a rectangular cell of Γ=12 for ψ=-0.11. Our numerical simulations were performed by solving the two-dimensional hydrodynamic equations using the SIMPLE method. Three types of convection patterns appearing in the nonlinear branch of the bifurcation diagram were observed. In particular, the undulation TW state in the rectangular cell was obtained, and the hysteresis in the transition from the TW State to the Stationary Overturning Convection (SOC) was verified. | Ning Li-zhong Institute of Hydraulic Engineering, Xi’an University of Technology, Xi’an 710048, China Department of Engineering, Nitto Co. Ltd., Ikebukuro 2-77-5, Toushima-ku, Tokyo 171-0014, Japan Yoshifumi Harada Department of Applied Physics, Fac | 2001 | Journal of Hydrodynamics2001，13，4： | 20 |
| 3 | Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients显示文摘AIM:To investigate prevalence,type and time of onset of extraintestinal manifestations(EIMs)in a series of Italian inflammatory bowel disease(IBD)patients.METHODS:Data of 811 IBD consecutive patients,first referred to our Centre from 2000 to 2011,were retrospectively evaluated.RESULTS:Eight hundred and eleven IBD patients(437M,374 F)were studied:595 ulcerative colitis(UC)(73.4%)and 216 Crohn’s disease(CD)(26.6%).Among these,329(40.6%)showed EIMs:210 UC(35.3%)and119 CD(55.1%)(P<0.0001).Considering the time of the diagnosis of IBD,37 EIMs(11.2%)were developed before,229(69.6%)after and 63(19.2%)were simultaneous.The type of EIM were as follows:240 musculoskeletal(29.6%),in 72 CD patients and in 168 UC(P<0.0001);47 mucocutaneous(5.8%),in 26 CD and in21 UC(P=0.0049);26 ocular(3.2%),in 16 CD and in10 UC(CD 7.4%vs UC 1.7%,P=0.0093);6 hepatobiliary(0.8%);10 endocrinological(1.2%).In particular,with regards to the involvement of the musculoskeletal system,arthritis Type 1 was found in 41 CD(19%)and in 61 UC(10.2%)(P=0.0012)and Type 2 in 25 CD(11.6%)and in 100 UC(16.8%)(P=0.0012).CONCLUSION:Mucocutaneous manifestations,arthritis Type 1 and uveitis were significantly more frequent in CD than UC.The complications of the musculoskeletal system were the mostly observed ones,often with symptoms more severe than intestinal ones,confirming the need for close cooperation with rheumatologists. | Maddalena Zippi Claudia Corrado Roberta Pica Eleonora Veronica Avallone Claudio Cassieri Daniela De Nitto Paolo Paoluzi Piero Vernia | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 4 | Interleukin-21 triggers effector cell responses in the gut显示文摘In the gut of patients with Crohn's disease and patients with ulcerative colitis,the major forms of inflammatory bowel diseases(IBD) in humans,the tissue-damaging immune response is mediated by an active cross-talk between immune and non-immune cells.Accumulating evidence indicates also that cytokines produced by these cells play a major role in initiating and shaping this pathologic process.One such cytokine seems to be interleukin(IL)-21,a member of the common γ-chainreceptor family.IL-21 is produced in excess in the in-flamed intestine of patients with IBD mostly by activated CD4+ T helper cells co-expressing interferon-γ and follicular T helper cells.Moreover,both in vitro and in vivo studies indicate that excessive IL-21 production leads to the activation of multiple signaling pathways that expand and sustain the ongoing mucosal inflammation.In this article,we review the available data supporting the pathogenic role of IL-21 in IBD. | Daniela De Nitto Massimiliano Sarra Francesco Pallone Giovanni Monteleone | 2010 | World Journal of Gastroenterology2010，16，29： | 8 |
| 5 | Biological therapy for dermatological manifestations of inflammatory bowel disease显示文摘Ulcerative colitis and Crohn's disease are the two forms of inflammatory bowel disease(IBD). The advent of biological drugs has significantly changed the management of these conditions. Skin manifestations are not uncommon in IBD. Among the reactive lesions(immunemediated extraintestinal manifestations), erythema nodosum(EN) and pyoderma gangrenosum(PG) are the two major cutaneous ills associated with IBD, while psoriasis is the dermatological comorbidity disease observed more often. In particular, in the last few years, anti-tumor necrosis factor(TNF)-α agents have been successfully used to treat psoriasis, especially these kinds of lesions that may occur during the treatment with biological therapies. The entity of the paradoxical manifestations has been relatively under reported as most lesions are limited and a causal relationship with the treatment is often poorly understood. The reason for this apparent side-effect of the therapy still remains unclear. Although side effects may occur, their clinical benefits are undoubted. This article reviews the therapeutic effects of the two most widely used anti-TNF-α molecules, infliximab(a fusion protein dimer of the human TNF-α receptor) and adalimumab(a fully human monoclonal antibody to TNF-α), for the treatment of the major cutaneous manifestations associated with IBD(EN, PG and psoriasis). | Maddalena Zippi Roberta Pica Daniela De Nitto Paolo Paoluzi | 2013 | World Journal of Clinical Cases2013，1，2： | 5 |
| 6 | Involvement of interleukin-15 and interleukin-21, two γ-chain-related cytokines, in celiac disease显示文摘Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra-epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD. Extensive studies of molecules produced by immune cells in the gut of CD patients have led to identification of two cytokines, namely interleukin (IL)-15 and IL-21, which are thought to play a major role in orchestrating the mucosal inflammatory response in CD. Here we review the current knowledge of the expression and function of IL-15 and IL-21 in CD. | Daniela De Nitto Ivan Monteleone Eleonora Franzè Francesco Pallone Giovanni Monteleone | 2009 | World Journal of Gastroenterology2009，15，37： | 3 |
| 7 | The JEDI eventbased infrastructure and its application to the development of the OPSS WFMS 显示文摘 | CUGOLA G NITTO E D FUGGETTA A | 2001 | IEEE Trans on Software Engineering2001，27，9： | 1 |
| 8 | The JEDI event-based infrastructure and its application to the development of the OPSS WFMS显示文摘 | CUGOLA G NITTO E D FGGETTAU A | 2001 | IEEE Transactions on Software Engineering2001，27，9： | 1 |
| 9 | Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation显示文摘 | Majors AK Boehm CA Nitto H | 1997 | J Orthop Res1997，15，4： | 1 |
| 10 | The dual role of interleukin-25 in the control of immune-mediated pathologies显示文摘 | Caruso R Stolfi C De Nitto D | 2011 | Curr MolMed2011，11，1： | 1 |
| 11 | Selective retention of bone marrow-derived cells to enhance spinal fusion显示文摘 | Matsukura Y Nitto H | 2005 | Clin Orthop Relat Res2005，，432： | 1 |
| 12 | Supporting cooperation in the SPADE-1 environment 显示文摘 | Elisabetta Di Nitto | 1996 | IEEE Transactions on Software Engineering1996，22，12： | 1 |
| 13 | Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gullus gallus显示文摘 | Nitto T Dyer K D Czapiga M | 2006 | J Biol Chem2006，281，25： | 1 |
| 14 | Selective retention of bone marrow-derived cells to enhance spinal fusion显示文摘 | Matsukura Y Nitto H | 2005 | Clin Orthop Relat Res2005，，432： | 1 |
| 15 | Characterization of a ribonuclease gene and encoded protein from the reptile, Iguana iguana 显示文摘 | Nitto T Lin C Dyer K D | 2005 | Gene2005，352，： | 1 |
| 16 | Evolution and function of leukocyte RNase A ribonucleases of the avian species Callus gallus 显示文摘 | Nitto T Dyer KD Czapiga M | 2006 | The Journal of Biological Chemistry2006，281，25： | 1 |
| 17 | Spine fusion using cel matrix composites enriched in bone marrow-derived cel s显示文摘 | Muschler GF Nitto H Matsukura Y | | 0，，407： | 1 |
| 18 | Targeting IL-23 and Th17-cytokines in inflammatory bowel diseases显示文摘 | De Nitto D Sarra M Cupi ML | 2010 | Curr Pharm Des2010，16，33： | 1 |
| 19 | Cluster as knowledge platform 显示文摘 | Nitto E | 2000 | Proceedings of IRIS 23 Labor-atorium for Interaction Technology2000，，： | 1 |
| 20 | Alternative spliced variants inthe pantetheinase family of genes expressed in humanneutrophils 显示文摘 | Nitto T Inoue T Node K | 2008 | Gene2008，426，12： | 1 |
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