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2篇 您的检索式:作者名="Nirao M Shah"
    题名 作者 年代 出处 被引量
1Regulatory Mechanisms in Stem Cell Biology显示文摘Sean J Morrison Nirao M Shah David J Anderson 2002Cell2002,,3:1
2Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)显示文摘Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents,voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles(Microtus ochrogaster). We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases,the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography(micro CT) analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.Andrew H Jheon Michaela Prochazkova Michael Sherman Devanand S Manoli Nirao M Shah Lawrence Carbone Ophir Klein 2015International Journal of Oral Science2015,7,1:0
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