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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Validity of the visual analogue scale as an instrument to measure self‐efficacy in resuscitation skills显示文摘 | Nigel MTurner Anita JVan De Leemput Jos M TDraaisma PaulOosterveld Olle Th JTen Cate | 2008 | Medical Education2008，，5： | 4 |
| 3 | Molecular and physiological aspects of nitrate uptake in plants显示文摘 | Nigel M Crawford Anthony D.M Glass | 1998 | Trends in Plant Science1998，，10： | 3 |
| 4 | 'Green revolution' genes encode mutant gibberellin response modulators显示文摘 | Peng J R Donald E R Nigel M H | 1999 | Nature1999，400，： | 1 |
| 5 | Role of tissue factor in hemostasis, thrombosis, and vascular development 显示文摘 | Nigel M | 2004 | Arterioscler Thromb Vasc Biol2004，24，6： | 1 |
| 6 | Preoarati on of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | Suchat W Nigel M D Thomas R | 2000 | Pharm Res2000，17，6： | 1 |
| 7 | An immunological approach to detect phosphate stress in populations and single cells of photosynthetic pico- plankton显示文摘 | David J S Nigel J S Kirsten M D | 1997 | Appl and Environmental Microbiology1997，63，6： | 1 |
| 8 | Overview of PRESSS Research Program显示文摘 | Nigel Priestley M J | 1991 | PCI Journal1991，，4： | 1 |
| 9 | ProbabUis-tic modelling of CO2 corrosion laboratory data usingneural networks显示文摘 | NESIC S MAGNUS N NIGEL M | 2001 | Corrosion Science2001，43，7： | 1 |
| 10 | Employment branding in the knowledge economy显示文摘 | Michael T Ewing Leyland F Pitt Nigel M de Bussy and Pierre Berthon | 2002 | International Journal of Advertising2002，21，1： | 1 |
| 11 | The PRESSS Program-Current Status and Proposed Plans for Phase III 显示文摘 | Nigel Priestley M J | 1996 | PCI Journal1996，，2： | 1 |
| 12 | Glutathione modulates the level of free radicals produced in UVA-irradiated cells显示文摘 | Simon E T Nigel P Trevor J M | 2000 | Journal of Photochemistry and Photobiology B:Biology2000，57，： | 1 |
| 13 | Overview of PRESSS Research Program 显示文摘 | Priestley M J Nigel | 1991 | PCI Journal1991，，4： | 1 |
| 14 | Ecological re sponses to UV radiation: interactions between the biological effects of UV on plants and on associated or ganisms 显示文摘 | Nigel D P Jason P M McPherson M | 2012 | Physiologia Plantarum2012，145，4： | 1 |
| 15 | New Concrete Anchors for Carbon Fiber Reinforced Polymer Post-Tensioning Tendons--Part 1:State-of-the-Art Review/Design显示文摘 | Mathmoud M Reda Taha Nigel G Shrive | 2003 | ACI Structural Journal2003，100，1： | 1 |
| 16 | A ferricchelatereductase for iron uptake from soils显示文摘 | Nigel J R Catherine M P Connolly E L | 1999 | Nature1999，397，69： | 1 |
| 17 | Size effects in axially loaded square-section concrete prisms strengthened using carbon fiber reinforced polymer wrapping 显示文摘 | MARK J M TREVOR N G NIGEL G S | 2004 | Canadian Journal of Civil Engineering2004，35，4： | 1 |
| 18 | Overview of presss research program显示文摘 | PRIESTLEY M J NIGEL | 1991 | PCI Journal1991，36，4： | 1 |
| 19 | Ductility of squareconfined concrete columns 显示文摘 | Park R Nigel Priestley M J Gill W D | 1982 | Journal of the Structural Division ASCE1982，108，4： | 1 |
| 20 | Choice of opioid supplementation for day-case rigid bronchoscopy:a randomized placebo-controlled comparison of a bolus of remifentanil and alfentanil显示文摘 | Neil M Agnew Ngukhoon H Tan Nigel D.A Scawn Stephen H Pennefather Glenn N Russell | 2003 | Journal of Cardiothoracic and Vascular Anesthesia2003，，3： | 1 |
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