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149篇 您的检索式：作者名="Niemeier"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis显示文摘	Kittichai Promrat David E. Kleiner Heather M. Niemeier Elizabeth Jackvony Marie Kearns Jack R. Wands Joseph L. Fava Rena R. Wing	2009	Hepatology2009，，1：	2
3	Randomized controlled trial testing the effects of wetght loss on nonalcoholic steatohepatitis 显示文摘	Promrat K K1 einer DE Niemeier HM	2010	Hepatology2010，51，1：	1
4	Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis显示文摘	Promrat K Kleiner DE Niemeier HM		0，，01：	1
5	Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice显示文摘	Ragozin S Niemeier A Laatsch A Loeffler B Merkel M Beisiegel U	2005	Arterisocler Thromb Vasc Biol2005，25，7：	1
6	Measuring accessibility: An exploration of issues and alternatives显示文摘	HANDY S L NIEMEIER D A	1997	Environment and Planning A1997，29，11：	1
7	Measuring Accessibility:An Exploration of Issues and Alternatives显示文摘	Niemeier D A	1997	Environment and Planning A1997，29，：	1
8	Exercise, cancer and the immune response of monocytes 显示文摘	Peters C Lotzerieh H Niemeier B	1995	Antieaneer Res1995，15，：	1
9	Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-B! expression 显示文摘	Niemeier A Kovacs W J Strob 1 W	2009	Atherosclerosis2009，202，：	1
10	CO2 Emissions: Are Land-use Changes Enough for California to Reduce VMT? Specification of a Two-part Model with Instrumental Variables显示文摘	Valle D & Niemeier D	2011	Transportation Research B2011，45，1：	1
11	Measuring accessibility: an exploration of issues and alternatives显示文摘	Handy S L Niemeier D A	1997	Environment and planning A1997，29，7：	1
12	Estimating regional air quality vehicle emission inventories: constructing robust driving cycles 显示文摘	Lin J Niemeier D A	2003	Transportation Science2003，37，3：	1
13	An exploratory analysis comparing a stochastic driving cycle to california's regulatory cycle 显示文摘	Lin J Niemeier D A	2002	Atmospheric Environment2002，36，38：	1
14	Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo显示文摘	Heeron J Niemeier A Merkel M	2002	J Mol Med2002，80，9：	1
15	Random- ized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis 显示文摘	Promrat K Kleiner DE Niemeier HM	2010	Hepatology2010，51，1：	1
16	Acne vulgaris-psychosomatic aspects显示文摘	Niemeier V Kupfer J Gieler U	2006	J Dtsch Dermatol Ges2006，4，12：	1
17	Travel to work and household responsibility: new evidence显示文摘	TURNER T NIEMEIER D	1997	Trans- portation1997，24，4：	1
18	Characterizing the effects of driver variability on real-world vehicle emissions 显示文摘	HOLMEN B A NIEMEIER D A	1998	Transportation Research Part D : Transportation and Environment1998，3，2：	1
19	A combinedmolecular-pathologic score improves risk stratification of thyroidpapillary microcarcinoma显示文摘	Niemeier LA Kuffner Akatsu H Song C	2012	Cancer2012，118，8：	1
20	Estimating regional air quality vehicle emission inventories : constructing robust driving cycles显示文摘	JIE lin NIEMEIER D A	2003	Transportation Science2003，37，3：	1

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