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| 1 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 2 | Scalable parallel programming with CUDA显示文摘 | Nickolls John Buck Ian Garland Michael | 2008 | International Conference on Computer Graphics and Interactive Techniques2008，6，2： | 1 |
| 3 | Abnormal expression of pRb,p16,and CyclinD1 in gastric adenocarcinoma and its lymph node metastases:relationship with Pathological features and survival显示文摘 | Feakins R M Nickols C D Bidd H | 2003 | Hum Pathol2003，34，12： | 1 |
| 4 | Thromboxane synthase immunohistochemistry in inflammatory bowel disease显示文摘 | Carty E Nickols C Feakins RM | 2002 | J Clin Pathol2002，55，5： | 1 |
| 5 | Nvidia tesla:A unified graphics and computing architecture显示文摘 | Lindholm E Nickolls J Oberman S | 2008 | IEEE Micro2008，28，2： | 1 |
| 6 | The GPU computing era显示文摘 | Nickolls J Dally W J | 2010 | IEEE Micro2010，30，2： | 1 |
| 7 | Scalable parallel programming with CUDA显示文摘 | Nickolls J Buck I Garland M | 2008 | Queue2008，6，2： | 1 |
| 8 | Parallel computing experiences with CUDA显示文摘 | Garland M Grand S L Nickolls J | 2008 | IEEE Micro2008，28，4： | 1 |
| 9 | Abnormal expression of pRb,p16,and cyclin D1 in gastric adenocarcinoma and its lymphnode metastases:relationship with pathologicl features and survival显示文摘 | FEAKINS R M NICKOLS C D | 2003 | Hum Pathol2003，34，12： | 1 |
| 10 | Scalable parallel programming with CUDA 显示文摘 | Nickolls J Buck I Garland M | 2008 | ACM Queue2008，6，2： | 1 |
| 11 | A peptidomimetic antagonist of the alpha(v) beta-3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo显示文摘 | Nickols GA Ross FP | 1997 | J Clin Invest1997，99，9： | 1 |
| 12 | Parallel computing experiences with CUDA显示文摘 | Garland M Grand S L Nickolls J | 2008 | Micro IEEE2008，28，4： | 1 |
| 13 | A peptidomimetic antagonist of the αvβ3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo 显示文摘 | Engleman VW Nickols GA RossFP | 1997 | J Clin Invest1997，99，9： | 1 |
| 14 | NVIDIA Tesla: A Unified Graphics and Computing Architecture显示文摘 | Lindholm E Nickolls J Oberman S | 2008 | IEEE Micro2008，28，2： | 1 |
| 15 | Parallel Computing Experiences-With CUDA Micro显示文摘 | Garland M Grand S L Nickolls J | 2008 | IEEE2008，28，4： | 1 |
| 16 | Low - fat dairy intake and body weight and composition changes in college students 显示文摘 | Kavitar KH Hosig KW Nickols - Richardson SM | 2009 | J Am Diet Assoc2009，109，8： | 1 |
| 17 | Bone cell function,regulation,and communication:A role for nitric oxide显示文摘 | Collin-Osdoby P Nickols GA Osdoby P | | 0，，03： | 1 |
| 18 | Scalable parallel programming with CUDA显示文摘 | NICKOLLS J BUCK I GARLAND M | | 0，，02： | 1 |
| 19 | Implantable cardioverter defibrillator electrogram recognition with a multilayer perceptron显示文摘 | Farrugia S Yee H Nickolls P | 1993 | Pacing Clin Electrophysiol1993，16，： | 1 |
| 20 | Smooth muscle inclusion bodies in slow transit constipation 显示文摘 | Knowles CH Nickols CD Scott SM | 2001 | J Pathol2001，193，3： | 1 |
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