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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 3 | On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35–70 of gestation显示文摘 | T. Goyarts S. D?nicke K.-P. Brüssow H. Valenta K.-H. Uebersch?r U. Tiemann | 2007 | Toxicology Letters2007，，1： | 2 |
| 4 | Phytomining 显示文摘 | BR()( )KS R R CHAMBERS M F NICKS J | 1998 | Trends in Plan* Sci1998，3，9： | 1 |
| 5 | Interpreting diel hysteresis between soil respiration and temperature显示文摘 | Clairel P Nick N David R | 2011 | Global Change Biology2011，17，： | 1 |
| 6 | A novelmicromachined pump based on thick-film piezoelectric actuation显示文摘 | Michael Koch Nick Harris Alan G R Evans | 1998 | Sens Actuators A1998，70，： | 1 |
| 7 | A Cluster Analysis of the KM field显示文摘 | Moharmnad H R M Nick Bontis | 2009 | Management Decision2009，47，5： | 1 |
| 8 | Simulator for Water Resources in Rural Basins 显示文摘 | WILLIAMS J R NICKS A D A MOLD J G | 1985 | Journal of Hydraulic Engineering1985，111，6： | 1 |
| 9 | Relationship Between the National ED Overcrowding Scale and the Number of Patients Who Leave Without Being Seen in an Academic ED显示文摘 | Weiss S J Ernst A A Derlet R King R Bair A Nick T G | 2005 | Am J Emerg Med2005，23，3： | 1 |
| 10 | A comprehensive surface-groundwater flow model显示文摘 | Arnold J G Williams J R Nicks A D | 1993 | Hydrol1993，142，： | 1 |
| 11 | Ontology-based semantic matchmaking approach显示文摘 | GAO SHU OMER F R NICK J A | 2007 | Advances in Engineering Software2007，38，1： | 1 |
| 12 | A novel micromachined pump based on thick-film piezoelectric actuation 显示文摘 | MICHAEL K NICK H ALAN G R | 1998 | Sens Actuators A1998，70，： | 1 |
| 13 | Buenfeld, Influence of aggregate size and volume fraction on shrinkage indueed micro-cracking of concrete and mortar显示文摘 | GRASSL Peter WONG Hong S NICK R | 2010 | Cement and Concrete Research2010，，1： | 1 |
| 14 | A modeling approach to evaluate best management practice显示文摘 | Williams R D Nicks A D | 1993 | Water Science and Technology1993，28，3： | 1 |
| 15 | Predictors and treatment re- sponse with cardiac resynchronization therapy in patients with heart failure characterized by dyssynchrony: a pre - defined analysis from the CARE-HFtrial显示文摘 | Matthew R Nick F Melanie J | 2007 | Eur Heart J2007，28，15： | 1 |
| 16 | Using soil erosion models for global change studies 显示文摘 | Williama J R Nearing M Nick A | 1996 | J Soil Water Cons1996，，： | 1 |
| 17 | Artificial activation of porcine oocytes matured in vitro显示文摘 | PRATHER R S EICHEN P A NICKS D K | 1991 | Molecular Reproduction Development1991，28，： | 1 |
| 18 | Simulator for Water Resources in Ru-ral Basins显示文摘 | Williams J R Nicks A D A mold J G | 1985 | Journal of Hydraulic Engineering1985，111，6： | 1 |
| 19 | Genomic regions determining resistance to leaf stripe (Pyrenophora graminea ) in barley显示文摘 | Arru L Nicks R E Lindhout P | 2002 | Genome2002，45，： | 1 |
| 20 | Phyto-mining显示文摘 | Brooks R R Chambers M F Nicks L J | 1998 | Trends in Plant Sci1998，3，： | 1 |
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