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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Blastocyst transfer after enzymatic treatment of the zona pellucide:improving in vitro fertilization and understanding implantation显示文摘 | Bongso A Ng SC | 1998 | Hum Reprod1998，13，10： | 1 |
| 3 | Fractures of the proximal interphalangeal joints of the fingers显示文摘 | Ng CY Oliver CW | | 0，，： | 1 |
| 4 | Central neurocytomas are genetically distinct from oligodendrogliomas and neuro-blastomas显示文摘 | Tong CY Ng HK Pang JC | 2000 | Histopathology2000，37，2： | 1 |
| 5 | An aid to the explanation of surgical risks and complications: the International Spinal Surgery Information Sheet 显示文摘 | Ng CY Gibson JN | 2011 | Spine (Phila Pa 1976)2011，36，26： | 1 |
| 6 | Isolation and culture of inner cell mass cells from human blastocysts显示文摘 | Bongso A Fong CY Ng SC | 1994 | Hum Reprod1994，9，11： | 1 |
| 7 | An aid to the explanation of surgical risks and complications: the International Spinal Surgery In- formation Sheet显示文摘 | Ng CY Gibson JNA | 2011 | Spine2011，36，26： | 1 |
| 8 | ^18F-FDG PET-CT in the evaluation of paraneoplastic syndromes: experience at a regional oncology centre显示文摘 | Vaidyanathan S Permington C Ng CY | 2012 | Nucl Med Commun2012，33，8： | 1 |
| 9 | Coculture: a new lead in embryo quality improvement for assisted reproduction 显示文摘 | Ng SC Fong CY | 1991 | Fertil Steril1991，56，1： | 1 |
| 10 | Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis显示文摘 | Leong XF CY Ng Jaarin K | 2015 | Biomed Res Int2015，2015，52： | 1 |
| 11 | A follow-up study of atypical squamous cells in gynecologic cytology using conventional papanicolaou smears and liquid-based preparations:the impact of the Bethesda System 2001显示文摘 | Lee CY Ng WK | 2007 | Am J Clin Pathol2007，127，4： | 1 |
| 12 | Myopia and Educational Attainment in 421,116 Young Singaporean Males显示文摘 | Tay MT Au Eong KG Ng CY | 1992 | Ann Acad Med Singapore1992，21，6： | 1 |
| 13 | Radon Release From Building Materials in Hong Kong 显示文摘 | Tso MYW Ng CY Leung JKC | 1994 | Health Phys1994，63，： | 1 |
| 14 | Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomas显示文摘 | Tong CY Ng HK Pang JC | 2000 | Histopathology2000，37，2： | 1 |
| 15 | Clinical characteristics of an outbreak of hand,foot and mouth disease in Singapore显示文摘 | Shah VA Chong CY Chan KP Ng W Ling AE | 2003 | Ann Acad Med Singapore2003，32，3： | 1 |
| 16 | Serum IGF-binding proteins-6 and prostale specifie antigen in of breast cancer 显示文摘 | Kaulsay KK Ng EH Ji CY | 1999 | Eur J Endocrinol1999，140，2： | 1 |
| 17 | Manipulation under anaesthesia and early physiotherapy facilitate recovery of patients with frozen shoulder syndrome显示文摘 | Ng CY Amin AK Narborough S | 2009 | Scott Med J2009，54，1： | 1 |
| 18 | Rctroviral vector-prnducer cell mediated angiogenesis inhibition restricts neuroblastoma growth in vivo 显示文摘 | Davidoff AM Leary MA Ng CY | 2000 | Med Pediatr Oncol2000，35，6： | 1 |
| 19 | Retroviral vector -producer cell mediated angiogenesis inhibition restricts neuroblastoma growth in vivo显示文摘 | Davidoff AM Leary MA Ng CY | 2000 | Med Pediatr Oncol2000，35，6： | 1 |
| 20 | Improved pregnacy rate after transfer of embryos grown in human fallopian tubal cell coculture显示文摘 | Ng SC Fong CY | 1992 | Fertil Steril1992，58，： | 1 |
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