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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 3 | Lymphangioleiomyomatosis (LAM) :a review of clinical and morphological features显示文摘 | Ferrans V J Yu ZX Nelson WK | 2000 | J Nippon Med Sch2000，67，5： | 1 |
| 4 | Optical properties of large-area polycrystalline chemical vapor deposited graphene by spectroscopic ellipsometry显示文摘 | Nelson F J Kamineni V K Zhang T | 2010 | Applied Physics Letters2010，97，25： | 1 |
| 5 | Follicular depletion during the menopausal transition:evidence for accelerated loss and ultimate exhaustion显示文摘 | Richardson SJ Senikas V Nelson JF | 1987 | J Clin Endocrinology Metab1987，65，6： | 1 |
| 6 | Safety and antiviral activity of albinterferon alfa-2b in prior interferon nonresponders with chronic hepatitis C显示文摘 | Nelson DR Rustgi V Balan V | 2009 | Clin Gastroenterol Hepatol2009，7，2： | 1 |
| 7 | Toxicity of four organophorus insecticides to a malathion resistant strain of the Indian meal moth in north Carolina USA 显示文摘 | Bandode P C Campbell W V Nelson L A | 1981 | Journal of Economic Entomology1981，74，4： | 1 |
| 8 | Growth and development of Lilium longiflorum 'Nellie White' during bulb production under controlled environments Ⅱ:Effects of shifting day/night temperature regimes on scale bulblets显示文摘 | Kim S H Niedziela J C E Nelson P V | 2007 | Scientia Horticulturae2007，，112： | 1 |
| 9 | Cyclooxygenasesin cancer:progress and perspective显示文摘 | Zha S Yegnasubramanian V Nelson WG | 2004 | Cancer Lett2004，215，1： | 1 |
| 10 | Biochemical and antiproliferative properties of 4-pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptm tyrosine kinase inhibitor显示文摘 | Fry DW Nelson JM Slintak V | 1997 | Biochem Pharmacol1997，54，8： | 1 |
| 11 | A comparison of intrathecal fentanyl and sufentanil for labor analgesia 显示文摘 | Nelson KE Rauch T Terebuh V | 2002 | Anesthesiology2002，96，5： | 1 |
| 12 | Cyclooxygenase-2 in cancer progress and perspective显示文摘 | ZHA Shan YEGNASUBRAMANIAN V NELSON W G | 2004 | Cancer Letters2004，215，1： | 1 |
| 13 | Antitumor necrosis factor- monoclonal antibody therapy for gastrointestinal Behcet' s disease: acase report 显示文摘 | Hassard PV Binder SW Nelson V | 2001 | Gastroenterology2001，120，： | 1 |
| 14 | Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4/beta2 nicotinic acetylcholine receptors 显示文摘 | Kuryatov A Gerzanich V Nelson M | 1997 | J Neurosci1997，17，23： | 1 |
| 15 | Capacitive Sensors for Measuring Single-kernel Moisture Content in Corn显示文摘 | Kandala C V K Leffler R G Nelson S O | 1987 | American Society of Agricultural Engineers1987，30，3： | 1 |
| 16 | Pilon fractures of the distal tibia 显示文摘 | Mandracchia V J Evans RD Nelson SC | 1999 | Clin Podiatr Med Surg1999，16，4： | 1 |
| 17 | A comparison of intrathecal fentanyl and sufentanil for labor analgesia显示文摘 | Nelson K E Rauch T Terebuh V | 2002 | Anesthesiology2002，96，5： | 1 |
| 18 | Lymphangioleiomyomatosis (LAM) : a review of clinical and morphological features 显示文摘 | FERRANS V J YU Z X NELSON W K | 2000 | J Nippon Med Sch2000，67，5： | 1 |
| 19 | Cyclooxygenases in cancer progress and perspective显示文摘 | ZHA S YEGNASUBRAMANIAN V NELSON W G | 2004 | cancer Lett2004，215，1： | 1 |
| 20 | Rapid Killing of Streptococcus, Pneumoniae with a Bacteriophage Cell Wall Hydrolase 显示文摘 | Loeffler J M D Nelson V A Fischetti | 2001 | Scince2001，294，： | 1 |
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