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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | 保存大豆种质遗传完整性的策略:Ⅰ细化表型分级标准精细整理大豆库存种质显示文摘以中国大豆种质资源在美国的种植调查数据为资料,并与中国的调查数据进行比较,旨在研究大豆种质的遗传完整性,为中国大豆资源的繁种保存策略提供参考。中国大豆种质资源2093份在美国利用不同的调查标准进行农艺性状重新鉴定评价,30%的中国大豆种质资源可进一步分为不同的纯系,使种质的数量增加到3062份。以纯化后种质份数增加到9份的资源ZDD4572为例,对其纯化过程进行了详细分析。研究表明,现有的大豆资源在纯合保存前提下,用更多的评价性状、每个性状划分更多的等级,将有助于大豆种质资源的纯化及其数量的增加,从而更方便繁种和实际利用。 | 闫龙 Nelson R L 常汝镇 邱丽娟 | 2010 | 植物遗传资源学报2010，11，6： | 4 |
| 3 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Lead distribution in a simulated aquatic environment:effects of bacterial biofilms and iron oxide显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Water Research1995，29，8： | 2 |
| 6 | Adsorption of Pb and Cd onto metal oxides and organic material in natural surface coatings as determined by selective extractions:New evidence for the Importance of Mn and Fe Oxides显示文摘 | Dong D Nelson Y M Lion L W | 2000 | Water Research2000，34，2： | 2 |
| 7 | Ductility reduction factor in the seismic design of buildings 显示文摘 | NELSON L JOHN W GRAHAM H | 1998 | Earthquake Engineering & Structural Dynamics1998，27，7： | 2 |
| 8 | Soil moisture: A central and unifying theme in physical geography显示文摘 | Legates David R Mahmood Rezaul Levia Delphis F DeLiberty Tracy L Quiring Steven M Houser Chris Nelson Frederick E | 2011 | Progress in Physical Geography2011，，1： | 2 |
| 9 | Effect of calcium hydroxide on bacterial endotoxin in vivo 显示文摘 | Silva L Nelson Filho P Leonardo MR | 2002 | J Endod2002，28，2： | 1 |
| 10 | Techniques for the isolation, culture and preservation of the Fusaria显示文摘 | Tio M Burgess L W Nelson P E | 1977 | Australian Plant Pathology Society Newsletter1977，6，： | 1 |
| 11 | Comparison of dermatopharmacokinetic vs clinicial efficacy methods for bioequivalenee assessment of miconazole nitrate vaginal cream, 2% in humans 显示文摘 | PERSHING L K CORLETT J L NELSON J L | 2002 | Pharm Res2002，19，3： | 1 |
| 12 | Entrepreneurship Research in Emergence:Past Trends and Future Directions显示文摘 | BUSENITZ L W WEST G F SHEPHERD D NELSON T CHANDLER G N ZACHARAKIS A | 2003 | Journal of Management2003，29，3： | 1 |
| 13 | P53 functions as a cell cycle control protein in osteosarcomas,显示文摘 | Kassel J Nelson CE | 1990 | Mol Cell Biol1990，10，11： | 1 |
| 14 | The role of hepatitis C virus-specific cytotoxic T-lymphocytes in chronic hepatitis C显示文摘 | Marousis C G Davis G L | 1997 | J Immunol1997，158，： | 1 |
| 15 | Mutant gene that changes protein composition and increase lysine content of maize endosperm显示文摘 | Mertz E F Bates L S Nelson O E | 1964 | Science1964，145，3629： | 1 |
| 16 | A look at the statistical identification of critical process parameters in friction stir welding 显示文摘 | RECORD J H COVINGTON J L NELSON T W SORENSEN C D WEBB B W | 2007 | Welding Journal2007，86，4： | 1 |
| 17 | Changes in round bales during storge 显示文摘 | Verma L Nelson B D | 1983 | Trans ASAE1983，26，： | 1 |
| 18 | Modeling Oligotrophic Biofilm Formation and Lead Adsorption to Bilfilm Components 显示文摘 | Nelson Y M Lion L M Shuler M L | 1996 | Environ Sci Technol1996，30，6： | 1 |
| 19 | 显示文摘 | Benrashid R Nelson G L Linn J H | 1993 | Journal of Applied Polymer Science1993，49，： | 1 |
| 20 | The evolution of raindrop spectra in warm-based convective storms as observed and numerically modeled显示文摘 | Carbone R E Nelson L D | 1978 | J Atmos Sci1978，35，12： | 1 |
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