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| 1 | 中国两栖动物保护需求总述显示文摘通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议. | 谢锋 刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox Debra L Fischman | 2006 | 中国科学(C辑)2006，36，6： | 28 |
| 2 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 3 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 4 | Oxygen isotope fractionation divalent metal carbonates显示文摘 | O'Neil J R Clayton R N Mayada T K | 1969 | Chemistry Geophysics1969，51，： | 1 |
| 5 | Chlamydia pneumoniae exposure and inflammatory markers in acaute coronary syndrome (CIMACS) 显示文摘 | Chandra HR CHoudhary N O' Neil C | 2001 | Am J Cardiol2001，88，3： | 1 |
| 6 | CT angiography in acute ischemic stroke:preliminary results显示文摘 | Piero V Lawrence N T Neil M B | 2002 | Stroke2002，33，： | 1 |
| 7 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 8 | Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin 显示文摘 | Jouvenet N Neil S J Zhadina M | 2009 | J Virol2009，83，4： | 1 |
| 9 | Improved reliability modeling using Bayesian networks and dynamic discretization 显示文摘 | MARQUEZ D NEIL M FENTON N | 2010 | Reliability Engineering & System Safely2010，95，4： | 1 |
| 10 | Using Bayesian networks to predict software defects and reliability 显示文摘 | Fenton N Neil M Marquez D | 2008 | Proceedings of the Institution of Mechanical Engineers Part O: Journal of Risk and Reliability2008，222，4： | 1 |
| 11 | Agreement of Time-Domain and Spectral-Domain Optical Coherence Tomography with Fluorescein Leakage from Choroidal Neovascularization显示文摘 | Rahul N. Khurana Bénédicte Dupas Neil M. Bressler | 2010 | Ophthalmology2010，，7： | 1 |
| 12 | Concurrent engineering: a schedule reduction tool显示文摘 | Neil N Eldin | 1997 | Journal of Construction Engineering and Management1997，123，3： | 1 |
| 13 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 14 | Using bayesian belief networks to predict the reliability of military vehicles 显示文摘 | Neil M Fenton N Forey S | 2001 | Computing and Control Engineering Journal2001，12，1： | 1 |
| 15 | iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human显示文摘 | Bergamaschi D Samuels Y O'Neil N J | 2003 | Nat Genet2003，33，2： | 1 |
| 16 | Markov chain monte carlo methods for stochastic volatility models显示文摘 | Siddhartha C Federico N and Neil S | 2002 | Journal of Econometrics2002，108，2： | 1 |
| 17 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972，77，： | 1 |
| 18 | How does modifying a DEM to reflect known Hydrology affect subsequent terrain analysis显示文摘 | Callow J N Van Neil K P Boggs G S | 2007 | Journal of Hydrology2007，，： | 1 |
| 19 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972，77，： | 1 |
| 20 | Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease显示文摘 | Bénédicte Stengel Michelle E. Tarver–Carr Neil R. Powe Mark S. Eberhardt Frederick L. Brancati | 2003 | Epidemiology2003，，4： | 1 |
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