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| 1 | HIsmelt炼铁工艺显示文摘非高炉炼铁HIsmelt工艺特征是:向熔池内直接喷吹铁矿粉和煤粉,形成熔炼炉下部的熔炼和上部鼓入富氧热风形成的二次燃烧。其核心是:通过喷溅完成上部燃烧区(高氧势)到下部熔炼区(低氧势)的热传递。西澳奎纳纳(Kwinana)建成首座80万t/a的HIsmelt工厂。2005年4~10月完成热调试,从此进入长时间的生产摸索期。主体冶炼工艺表明其生产率可达设计产能的75%~80%,主工艺喷吹煤比约为800kg/t。热矿喷吹系统(外围)可进一步优化,如果2010年市场形势好转,将对其进行改进,并会将熔炼炉排出的煤气引入矿粉预热器,以期提高生产率,接近设计产能的100%,且煤比降至约700kg/t。由于一些原因,工厂作业率不是很理想。低的作业率(即频繁开停)导致耐材寿命很短。为了延长耐材寿命,2008年工厂安装了一套铜质水冷渣线冷却器,显著延长了炉役周期,并极大提升了工厂的操作水平。HIsmelt的熔炼炉是关键所在,除此外其他影响作业率的因素在奎纳纳已不是问题。目前就是不断解决限制产能发挥的各种问题。 | Neil Goodman Rod Dry 王东彦(译) 关运泽(校) | 2010 | 世界钢铁2010，，2： | 10 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | Interaction of prostate specific membrane antigen with clathrin andthe adaptor protein complex-2显示文摘 | Oscar Goodman Sonali Barwe Brigitte Ritter Peter McPherson Ann-Jeanette Vasko James Keen David Nanus Neil Bander Ayyappan Rajasekaran | 2007 | International Journal of Oncology2007，，5： | 1 |
| 4 | Tumor size, depth of invasion, and histologic grade as prognostic factors of lymph node involvement in endometrial cancer: A SEER analysis显示文摘 | Roberto Vargas J. Alejandro Rauh-Hain Joel Clemmer Rachel M. Clark Annekathryn Goodman Whitfield B. Growdon John O. Schorge Marcela G. del Carmen Neil S. Horowitz David M. Boruta | 2014 | Gynecologic Oncology2014，，： | 1 |
| 5 | Development of The Hi-Vap BOF Cooling System显示文摘 | Neil J Goodman David Brown | 1993 | Iron and Steel Engineer1993，70，11： | 1 |
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