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| 1 | Triggers of histologically suspected drug-induced colitis显示文摘BACKGROUND Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents.Although withdrawal of the causative agent would cure the disease knowledge is scarce and mostly derives from case reports and series.AIM To investigate potential triggers of drug-induced colitis(DiC).METHODS We conducted a retrospective,observational case control study.Patients were assigned to DiC or one of two age-and gender-matched control groups(noninflammatory controls and inflammatory colitis of another cause)based on histopathological findings.Histopathology was reassessed in a subset of patients(28 DiC with atherosclerosis,DiC without atherosclerosis and ischaemic colitis each)for validation purposes.Medical history was collected from the electronic database and patient records.Statistical analysis included chi-squared test,t-test,logistic and multivariate regression models.RESULTS Drug-induced colitis was detected in 211 endoscopically sampled biopsy specimens of the colon mucosa(7%of all screened colonoscopic biopsy samples);a total of 633 patients were included equally matched throughout the three groups(291 males,mean age:62.1±16.1 years).In the univariate analysis,DiC was associated with diuretics,dihydropyridines,glycosides,ASS,platelet aggregation inhibitors,nonsteroidal anti-inflammatory drugs(NSAIDs),statins and fibrates,and with atherosclerosis,particularly coronary heart disease,and hyperlipoproteinaemia.Echocardiographic parameters did not show substantial differences.In the multivariate analysis only fibrates[odds ratio(OR)=9.1],NSAIDs(OR=6.7)and atherosclerosis(OR=2.1)proved to be associated with DiC.Both DiC reassessment groups presented milder inflammation than ischaemic colitis.The DiC patients with atherosclerosis exhibited histological features from both DiC without atherosclerosis and ischaemic colitis.CONCLUSION Several drugs indicated for the treatment of cardiovascular and related diseases are associated with DiC.Atherosclerosis and microcirculatory disturbances seem to play an important pathogenetic role. | Thorsten Brechmann Katharina Günther Matthias Neid Wolff Schmiegel Andrea Tannapfel | 2019 | World Journal of Gastroenterology2019，25，8： | 3 |
| 2 | Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells显示文摘 | Neid M Datta K Stephan S | 2004 | J Boil Chem2004，279，6： | 1 |
| 3 | Cancer Invasion and Metastasis显示文摘 | Wittekind C Neid M | 2005 | Oncolo-gy2005，69，1： | 1 |
| 4 | Alleviation of salt-induced stress on seed emergence using soil additives in a greenhouse显示文摘 | Neid S L Biesboer D | 2005 | Plant and Soil2005，268，： | 1 |
| 5 | Cancer invasion and metastasis显示文摘 | Wittekind C Neid M | 2005 | Oncology2005，69，1： | 1 |
| 6 | Practical significance of cytokine determination in joint fluid in patients with arthroses or rheu-matoid arthritis显示文摘 | Neide J Schlze M Sovai L | 2004 | Orthop Ihre Grenzgeb2004，134，： | 1 |
| 7 | Prognostic significance of proliferation markers in hepatocellular carcinoma (HCC) 显示文摘 | Ebelt J Neid M Tannapfel A | 2000 | Zentralbl Chir2000，125，7： | 1 |
| 8 | Cancer Invasion and Metastasis显示文摘 | Wittekind C Neid M | | 0，，1： | 1 |
| 9 | The origins of colorectal carcinoma:specific nomenclature for different pathways and precursor lesions显示文摘 | Tannapfel A Neid M Aust D | 2010 | Dtsch Arztebl Int2010，43，： | 1 |
| 10 | Human rabies显示文摘 | RAFAEL O NEIDE T PANLO B | 2006 | Emerging Infect Dis2006，12，5： | 1 |
| 11 | Prognostic significance of proliferation markers in hepatocellular carcinoma(HCC)显示文摘 | Ebelt J Neid M Tannapfel A | 2000 | Zentralbl Chir2000，125，7： | 1 |
| 12 | Prognostic significance of prolif- eration markers in hepatocellular carcinoma (HCC)显示文摘 | Ebelt J Neid M Tannapfel A | 2000 | Zentralbl Chir2000，125，7： | 1 |
| 13 | Cancer invasion and metastasis 显示文摘 | Wittekind C Neid M | 2005 | Oncology2005，69，1： | 1 |
| 14 | Prognostic significance of proliferation markers in hep-atocelluar carcinoma (HCC)显示文摘 | Ebelt J Neid M Tannapfel A | 2000 | Zentralbl Chir2000，125，7： | 1 |
| 15 | Determination of Total Proteins in Cow Milk Powder Samples:a Comparative Study between the Kjeldahl Method and Spectrophotometric Methods显示文摘 | NEIDE K K K MAURICIO M G CASSIA T B V Z | 2003 | Journal of Food Composition and Analysis2003，16，： | 1 |
| 16 | Role of insulin recep-tor substrates and protein kinase C in vascular permeability factor vascular endothelial growth factor expression in pancreatic cancer cells 显示文摘 | Matthias Neid Kaustubh D Susann S | 2004 | Biol Chem2004，279，6： | 1 |
| 17 | The origins of colorectal carcinoma: specific nomenclature for differenl pathways and precursor lesions显示文摘 | Tannapfel A Neid M Aust D | 2010 | Dtsch Arztebl Int2010，107，43： | 1 |
| 18 | Pseudotumerous enlargement of the umbilical cord owing to an intra-amniotie varicosity associa- ted with thrombocytopenia显示文摘 | Trtibs RB Teig N Neid M | 2012 | J Pediatr Surg2012，47，9： | 1 |
| 19 | Cancer invasion and metastasis显示文摘 | WITYEKIND C NEID M | 2005 | Oncology2005，69，1： | 1 |
| 20 | Determinationoftotal proteins in cow milk powder samplesa comparative study between the Kjeldahl method and spectrophotometric methods显示文摘 | Neide KK Zaia BV Dimas AM | 2003 | Journal of Food Composition and Analysis2003，16，4： | 1 |
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