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| 1 | Interstitial cells of Cajal in the gut-A gastroenterologist’s point of view显示文摘Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specifi c treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract. | Lucian M Negreanu Philippe Assor Bogdan Mateescu Catalin Cirstoiu | 2008 | World Journal of Gastroenterology2008，14，41： | 27 |
| 2 | Noninvasive investigations for non alcoholic fatty liver disease and liver fi brosis显示文摘Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that have insulin resistance in common and are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD ranges from simple liver steatosis, which follows a benign course, to nonalcoholic steatohepatitis (NASH), a more severe entity, with necroinflmmation and f ibrosis, which can progress to cryptogenic cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and f ibrosis; however, several noninvasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. These markers are currently neither available in all centers nor validated in extensive studies. Examples include high-sensitivity C reactive protein and plasma pentraxin 3, which are associated with extensive liver f ibrosis in NASH. Interleukin-6 correlates with inflammation, and cytokeratin-18 represents a marker of hepatocyte apoptosis (prominent in NASH and absent in simple steatosis). Tissue polypep-tide specif ic antigen seems to have a clinical utility in the follow-up of obese patients with NASH. | Carmen Fierbinteanu-Braticevici Ion Dina Ana Petrisor Laura Tribus Lucian Negreanu Catalin Carstoiu | 2010 | World Journal of Gastroenterology2010，16，38： | 21 |
| 3 | PillCam Colon 2 capsule in patients unable or unwilling to undergo colonoscopy显示文摘AIM: To assess the feasibility, accuracy and acceptability of PillCam Colon 2 in detection of significant lesions in colorectal cancer risk patients, unable or unwilling to perform colonoscopy. METHODS: This is a prospective, single center study using the second generation of PillCam Colon capsule. In all patients the readers were instructed to review the entire colon capsule endoscopy(CCE) examination using Rapid 7 software and additionally to note significant extra-colonic findings. Colonic significant findings were described according to European Society of Gastrointestinal Endoscopy guidelines. CCE procedure completion rate, level of bowel preparation and rate of adverse events were assessed. RESULTS: A total of 70 patients at risk of colorectal cancer were enrolled in the study. In three patients the procedure failed because the capsule was not functioning when entered the colon. PillCam Colon 2 showed positive findings in 23(34%, 95%CI: 21.6%-44.1%) of the remaining 67 patients. Six patients were diagnosedwith tumors: 4 with colon cancers, 1 with gastric cancer and 1 with a small bowel cancer. The capsule findings were confirmed after surgery in all these patients. The capsule excretion rate in twelve hours was 77% with 54 patients having a complete examination. The rectum was not explored during CCE procedure, in 16 patients(23%, 95%CI: 13.7%-34.1%). Every patient accepted CCE as an alternative exploration tool and 65/70(93%) agreed to have another future control by CCE. No complications were reported during or after CCE examination. CONCLUSION: PillCam Colon 2 capsule was effective in detecting significant lesions and might be considered an adequate alternative diagnostic tool in patients unable or unwilling to undergo colonoscopy. | Lucian Negreanu Ruxandra Babiuc Andreea Bengus Roxana Sadagurschi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 7 |
| 4 | Epidemiological trends in acute pancreatitis:A retrospective cohort in a tertiary center over a seven year period显示文摘BACKGROUND Acute pancreatitis(AP)remains a major cause of hospitalization and mortality with important health-related costs worldwide.Using an electronic database of a large tertiary center,we estimated the incidence,etiology,severity and costs of hospitalized AP cases in southern Romania.AIM To estimate the incidence,cost and tobacco usage of hospitalized AP cases in southern Romania and to update and upgrade the knowledge we have on the etiology,severity(in regard to Revised Atlanta Classification),outcome,morphology and local complications of AP.METHODS We performed an electronic health care records search on AP patients treated at Emergency University Hospital of Bucharest(Spitalul Universitar de UrgențăBucurești)between 2015 and 2022.The incidence,etiology,and severity were calculated;potential risk factors were evaluated,and the hospitalization costs of AP were documented and analyzed.The cohort of this study is part of the BUCharest-Acute Pancreatitis Index registry.RESULTS A total of 947 consecutive episodes of AP where the patients were hospitalized in the gastroenterology department were analyzed,with 79.45%as 1st episode and the rest recurrent.The majority of the patients were males(68.9%).Alcoholic(45.7%),idiopathic(16.4%)and biliary(15.2%)were the main causes.The incidence was estimated at 29.2 episodes/100000 people.The median length of stay was 7 d.The median daily cost was 747.96 RON(165 EUR).There was a high prevalence of active tobacco smokers(68.5%).The prevalence of severe disease was 11.1%.The admission rate to the intensive care unit was 4.6%,with a mortality rate of 38.6%.The overall mortality was 5.5%.CONCLUSION We estimated the incidence of AP at 29.2 episodes that required hospitalization per 100000 people.The majority of our cases were found in males(68.9%)and were related to alcohol abuse(45.7%).Out of the cases we were able to find data regarding tobacco usage,the majority were active smokers(68.5%).Most patients had a mild course(54.4%),with a mortality rate of 5.5%.Interstitial AP prevailed(45.3%).The median daily cost of hospitalization was 747.96 RON(165 EUR). | Andreea Irina Ghiță Mihai Radu Pahomeanu Lucian Negreanu | 2023 | World Journal of Methodology2023，13，3： | 2 |
| 5 | Role of capsule endoscopy Pillcam COLON 2 in patients with known or suspected Crohn’s disease who refused colonoscopy or underwent incomplete colonoscopic exam: a case series显示文摘 | L. Negreanu G. Smarandache R. B. Mateescu | 2014 | Techniques in Coloproctology2014，，3： | 2 |
| 6 | Transcription factors T- bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells显示文摘 | Djuretie IM Levanon D Negreanu V | 2007 | Nat lmmunol2007，8，2： | 1 |
| 7 | AML1,AML2 and AML3,the human members of the runt domain gene-family:cDNA structure,expression and chromosomal localization显示文摘 | Levanon D Negreanu V Bernstein Y | 1994 | Genomics1994，23，： | 1 |
| 8 | Loss of Runx3 function in leukocytes is associated with spontaneously developed colids and gastric mucosal hyperplasia 显示文摘 | Brenner O Levanon D Negreanu V | 2004 | Proc Nad Acad Sci USA2004，101，16： | 1 |
| 9 | Impact of treated wastewater irrigation on antibiotic resistance in agricuhural soils 显示文摘 | NEGREANU Y PASTERNAK Z JURKEVITCH E | 2012 | Environmental Science & Technology2012，46，9： | 1 |
| 10 | Portal hypertensive gastropathy显示文摘 | Negreanu L Busegeanu C Trandaflr D | 2005 | Rom J Intern Med2005，43，12： | 1 |
| 11 | AML1,AML2 and AML3,the human members of the runt domain gene-family;cDNA structure,expression,and chromosomal localization显示文摘 | Levanon D Negreanu V Bernstein Y | 1994 | Genomics1994，23，2： | 1 |
| 12 | Infrared technique for simultaneous determination of temperature and emissivity 显示文摘 | Herve P Cedelle J Negreanu L | 2012 | lnfrared Physics &Technology2012，55，1： | 1 |
| 13 | Portal bypertensive gastropathy显示文摘 | Negreanu L Busegeanu C Trandafir D | 2005 | Rom J Intern Med2005，43，12： | 1 |
| 14 | AML1,AML2 and AML3, the human members of the runt domaingene-family: cDNA structure, expression and chromosomallocalization 显示文摘 | Levanon D Negreanu V Bernstein Y | 1994 | Genomics1994，23，2： | 1 |
| 15 | Role of new endoscopic techniques in inflammatory bowel disease management: Has the change come?显示文摘Despite significant therapeutic progress in recent years,inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,remains a challenge regarding its pathogenesis and long-term complications.New concepts have emerged in the management of this disease,such as the'treat-totarget'concept,in which mucosal healing plays a key role in the evolution of IBD,the risk of recurrence and the need for surgery.Endoscopy is essential for the assessment of mucosal inflammation and plays a pivotal role in the analysis of mucosal healing in patients with IBD.Endoscopy is also essential in the detection of dysplasia and in the identification of the risk of colon cancer.The current surveillance strategy for dysplasia in IBD patients indicates white-light endoscopy with non-targeted biopsies.The new chromoendoscopy techniques provide substantial benefits for both clinicians and patients.Narrow-band imaging(NBI)has similar rates of dysplastic lesion detection as whitelight endoscopy,and it seems that NBI identifies more adenoma-like lesions.Because it is used instinctively by many endoscopists,the combination of these two techniques might improve the rate of dysplasia detection.Flexible spectral imaging color enhancement can help differentiate dysplastic and non-dysplastic lesions and can also predict the risk of recurrence,which allows us to modulate the treatment to gain better control of the disease.The combination of noninvasive serum and stool biomarkers with endoscopy will improve the monitoring and limit the evolution of IBD because it enables the use of a personalized approach to each patient based on that patient’s history and risk factors. | loredana goran lucian negreanu ana maria negreanu | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 16 | Infrared technique for simultaneous determination of temperature and emissivity显示文摘 | Philippe Herve Julie Cedelle Ionut Negreanu | 2010 | Infrared Physics and Technology2010，，1： | 1 |
| 17 | AML1,AML2,and AML3,the human members of the runt domain gene-family:cDNA structure,expression,and chromosomal localization显示文摘 | Levanon D Negreanu V Bemsteim Y | 1994 | Genomics1994，23，2： | 1 |
| 18 | AML1,AML2,and AML3,the human members of the runt domain gene-family:cDNA structure,expression,and chromosomal localization显示文摘 | Levanon D Negreanu V Bernsteirn Y | 1994 | Genomics1994，23，2： | 1 |
| 19 | Portal hypertensive gastropathy显示文摘 | Negreanu L Buregeanu C Trandafir D | 2005 | Rom J Intern Med2005，43，12： | 1 |
| 20 | Wavelet filtering for exact controllability of the wave equation显示文摘 | Negreanu M Matache A M Schwab C | | 0，，05： | 1 |
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