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您的检索式：作者名="Neelam Azad"
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| 1 | Fas配体对NIH3T3增殖和胶原表达的信号机制研究显示文摘目的探讨Fas配体(FasL)对小鼠成纤维细胞NIH3T3增殖和胶原表达的影响及其信号调控机制。方法采用鼠成纤维细胞系HIN3T3,以FasL为诱导剂,采用抑制剂技术和Western blot技术观察NIH3T3的增殖及胶原表达情况,同时探讨磷脂酰肌醇3-激酶(PI3K)/Akt、有丝分裂原活化蛋白(MAPK)/P38、MAPK/ERK信号通路在NIH3T3增殖和胶原表达中的作用。结果研究发现低剂量的FasL可调节3T3的生长,表现为细胞数量和胶原表达水平均随FasL剂量的增加而增加,且存在剂量-效应和时间-效应;MAPK/P38及PI3K/Akt信号通路对NIH3T3的增殖具有调控作用,MAPK/P38及MAPK/ERK信号通路可调控NIH3T3胶原表达。结论Fas/FasL系统对成纤维细胞增殖和胶原表达起促进作用;FasL主要通过PI3K/Akt、MAPK/P38信号通路对成纤维细胞增殖起调控作用;通过MAPK/P38及MAPK/ERK信号通路调节成纤维细胞的胶原表达。 | 姚三巧 LU Yongju WANG Liying Rojanasakul Anand Iyer Neelam Azad Yon Rojanasakul | 2010 | 中国职业医学2010，37，2： | 2 |
| 2 | Alternative models of cancer stem cells: The stemness phenotype model, 10 years later显示文摘The classical cancer stem cell(CSCs)theory proposed the existence of a rare but constant subpopulation of CSCs.In this model cancer cells are organized hierarchically and are responsible for tumor resistance and tumor relapse.Thus,eliminating CSCs will eventually lead to cure of cancer.This simplistic model has been challenged by experimental data.In 2010 we proposed a novel and controversial alternative model of CSC biology(the Stemness Phenotype Model,SPM).The SPM proposed a non-hierarchical model of cancer biology in which there is no specific subpopulation of CSCs in tumors.Instead,cancer cells are highly plastic in term of stemness and CSCs and non-CSCs can interconvert into each other depending on the microenvironment.This model predicts the existence of cancer cells ranging from a pure CSC phenotype to pure non-CSC phenotype and that survival of a single cell can originate a new tumor.During the past 10 years,a plethora of experimental evidence in a variety of cancer types has shown that cancer cells are indeed extremely plastic and able to interconvert into cells with different stemness phenotype.In this review we will(1)briefly describe the cumulative evidence from our laboratory and others supporting the SPM;(2)the implications of the SPM in translational oncology;and(3)discuss potential strategies to develop more effective therapeutic regimens for cancer treatment. | Vivek Kaushik Yogesh Kulkarni Kumar Felix Neelam Azad Anand Krishnan V Iyer Juan Sebastian Yakisich | 2021 | World Journal of Stem Cells2021，13，7： | 0 |
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