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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs. | Cristiana Pistol Tanase Ana Iulia Neagu Laura Georgiana Necula Cristina Mambet Ana-Maria Enciu Bogdan Calenic Maria Linda Cruceru Radu Albulescu | 2014 | World Journal of Gastroenterology2014，20，31： | 4 |
| 3 | High-energy hybrid femtosecond laser system demonstrating 2×10 PW capability显示文摘We report on a two-arm hybrid high-power laser system(HPLS)able to deliver 2×10 PW femtosecond pulses,developed at the Bucharest-Magurele Extreme Light Infrastructure Nuclear Physics(ELI-NP)Facility.A hybrid frontend(FE)based on a Ti:sapphire chirped pulse amplifier and a picosecond optical parametric chirped pulse amplifier based on beta barium borate(BBO)crystals,with a cross-polarized wave(XPW)filter in between,has been developed.It delivers 10 mJ laser pulses,at 10 Hz repetition rate,with more than 70 nm spectral bandwidth and high-intensity contrast,in the range of 1013:1.The high-energy Ti:sapphire amplifier stages of both arms were seeded from this common FE.The final high-energy amplifier,equipped with a 200 mm diameter Ti:sapphire crystal,has been pumped by six 100 J nanosecond frequency doubled Nd:glass lasers,at 1 pulse/min repetition rate.More than 300 J output pulse energy has been obtained by pumping with only 80%of the whole 600 J available pump energy.The compressor has a transmission efficiency of 74%and an output pulse duration of 22.7 fs was measured,thus demonstrating that the dual-arm HPLS has the capacity to generate 10 PW peak power femtosecond pulses.The reported results represent the cornerstone of the ELI-NP 2×10 PW femtosecond laser facility,devoted to fundamental and applied nuclear physics research. | François Lureau Guillaume Matras Olivier Chalus Christophe Derycke Thomas Morbieu Christophe Radier Olivier Casagrande Sébastien Laux Sandrine Ricaud Gilles Rey Alain Pellegrina Caroline Richard Laurent Boudjemaa Christophe Simon-Boisson Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Bertrand De Boisdeffre Petru Ghenuche Andrei Naziru Georgios Kolliopoulos Liviu Neagu Razvan Dabu Ioan Dancus Daniel Ursescu | 2020 | High Power Laser Science and Engineering2020，8，4： | 4 |
| 4 | Constructal-theory tree networks of 'constant' thermal resistance 显示文摘 | BEJAN A | 1999 | J Appl Phys1999，86，2： | 1 |
| 5 | Anti-Mullerian hormone-a prognostic marker for metformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome 显示文摘 | Neagu M Cristescu C | 2012 | J Med Life2012，5，： | 1 |
| 6 | Plasticity of regulatory T cells under cytokine pressure显示文摘 | Diaconu CC Neagu AI Lungu R | 2010 | Roum Arch Microbiol Immu- nol2010，69，4： | 1 |
| 7 | Organ printing: fiction or science显示文摘 | Jakab K Neagu A Mironov V Forgacs G | 2004 | Biorheology2004，41，34： | 1 |
| 8 | Diffusion tensor imaging in brainstem tuberculoma 显示文摘 | Lyons ]L Neagu MR Norton IH | 2013 | J Clin Neurosci2013，20，11： | 1 |
| 9 | Patented biomark- er panels in early detection of cancer 显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomarkers2011，1，1： | 1 |
| 10 | Labour Productivity and Human Capital in the Eu Countries:an Empirical Analys显示文摘 | Neagu Olimpia | | 0，，： | 1 |
| 11 | relaxation times and the The distribution of the thermally stimulated depolarization currents显示文摘 | Neagu R M Neagu E R | 2006 | Journal of Optoelectronics and Advanced Materials2006，8，3： | 1 |
| 12 | Concentration of Symphytum Officinale Extracts with Cytostatic Activity by Tangential Flow Ultrafiltration显示文摘 | ROMAN G NEAGU E MOROEANU V | 2008 | Roumanian Biotechnological Letters2008，16，8： | 1 |
| 13 | Study of a toxin-alkaline phosp hatase conjugate for the development of an immunosensor for tetrodotoxin determination 显示文摘 | NEAGU D MICHELI L PALLESCHI G | 2006 | Anal Bioanal Chemistry2006，385，6： | 1 |
| 14 | Characterization of a planar microcoil for implantable microsystems显示文摘 | Neagu C R Jansen H V Smith A | 1997 | Sensors and Actuators Physical1997，207，123： | 1 |
| 15 | Patented biomarker panels in early detection of cancer显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomark2011，1，1： | 1 |
| 16 | Fundamentals on face milling processing of straight shafts显示文摘 | Neagu C Gheorghe M Dumitrescu A | 2005 | Journal of Materials Processing Technology2005，166，3： | 1 |
| 17 | Reactive oxygen species,cancer and anti-cancer therapies显示文摘 | Manda G Nechifor MT Neagu TM | 2009 | Curr Chem Biol2009，3，1： | 1 |
| 18 | Fore-Arc and Back-Arc Ground Motion Prediction Model for Vrancea Intermediate Depth Seismic Source显示文摘 | R. Vacareanu M. Radulian M. Iancovici F. Pavel C. Neagu | 2015 | Journal of Earthquake Engineering2015，，3： | 1 |
| 19 | Trade in international maritime services: how much does policy matter?显示文摘 | Fink C Mat-too A Neagu I C | 2002 | The Worm Bank Economic Review2002，16，1： | 1 |
| 20 | Sorption studies of chromium (VI) onto new ion exchanger with tertiary amine, quaternary ammonium and ketone groups显示文摘 | W6jcik G Neagu V Bunia I | | Journal of Hazardous Materials0，190，1： | 1 |
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