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| 1 | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease显示文摘Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis.Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases.Impaired autophagy prevents the clearance of excessive lipid droplets(LDs),damaged mitochondria,and toxic protein aggregates,which can be generated during the progression of various liver diseases,thus contributing to the development of steatosis,injury,steatohepatitis,fibrosis,and tumors.In this review,we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases.We also examine the mechanisms of defects in autophagy,and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease(NAFLD)and alcoholic liver disease(ALD),focusing mainly on steatosis and liver injury.Finally,we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases. | Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu Xiao-Ming Yin | 2018 | Liver Research2018，2，3： | 13 |
| 2 | Comparative assessment of total polyphenols, antioxidant and antimicrobial activity of different tea varieties of Bangladesh显示文摘Objective: To determine the total polyphenol content, antioxidant activity and antibacterial properties of the extracts of different Bangladeshi tea varieties such as flowery broken orange pekoe, broken orange pekoe, red dust and green tea.Methods: Total phenolic and flavonoid contents were determined by Folin–Ciocalteu and aluminum chloride colorimetric assay, respectively.The antioxidant capacity was determined by ferric ion reducing antioxidant power and phosphomolybdenum method.Antibacterial activity was evaluated by disc diffusion method in agar plate and subsequently, the minimum inhibitory concentration was determined by broth dilution method.Results: Total phenolic and flavonoid contents were significantly higher(P < 0.05) in green tea compared to other three black tea varieties.The green tea also showed a higher free radical scavenging and antioxidant activities than all the other tea varieties tested(P < 0.05).In addition, the extracts of all four tea varieties showed inhibitory activity against several pathogenic bacteria and also the same trend of higher antimicrobial activity of green tea than other tea varieties was observed.Conclusions: Taken together, the results of this study demonstrated that Bangladeshi tea,especially the green tea, may act as a substitute for natural antioxidants and as a promising antibacterial agent for beneficial influence in human health. | Yead Morshed Nibir Ahmed Faisal Sumit Anwarul Azim Akhand Nazmul Ahsan Mohammad Shahnoor Hossain | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，4： | 6 |
| 3 | Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs显示文摘In recent years,several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells.These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells.Interestingly,this notion has also led scientists to question the role of proteins in the secretome produced by cells,tissues or organisms under certain conditions or at a particular time of regenerative therapy.Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs.This could also facilitate the migration of immune,progenitor and stem cells within the body to the site of inflammation.Of these different paracrine factors present within the secretome,researchers have given proper consideration to stromal cell-derived factor-1(SDF1)that plays a vital role in tissue-specific migration of the cells needed for regeneration.Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration.Hence in this study,we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed. | Nazmul Haque Ismail M Fareez Liew Fong Fong Chanchal Mandal Noor Hayaty Abu Kasim Kranthi RajaKacharaju Pratiwi Soesilawati | 2020 | World Journal of Stem Cells2020，12，9： | 3 |
| 4 | Hepatic senescence, the good and the bad显示文摘Gradual alterations of cell’s physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent cells.Once becoming senescent,the cell stops dividing permanently but remains metabolically active.Cellular senescence does not have a single marker but is characterized mainly by a combination of multiple markers,such as,morphological changes,expression of cell cycle inhibitors,senescence associatedβ-galactosidase activity,and changes in nuclear membrane.When cells in an organ become senescent,the entire organism can be affected.This may occur through the senescence-associated secretory phenotype(SASP).SASP may exert beneficial or harmful effects on the microenvironment of tissues.Research on senescence has become a very exciting field in cell biology since the link between age-related diseases,including cancer,and senescence has been established.The loss of regenerative and homeostatic capacity of the liver over the age is somehow connected to cellular senescence.The major contributors of senescence properties in the liver are hepatocytes and cholangiocytes.Senescent cells in the liver have been implicated in the etiology of chronic liver diseases including cirrhosis and hepatocellular carcinoma and in the interference of liver regeneration.This review summarizes recently reported findings in the understanding of the molecular mechanisms of senescence and its relationship with liver diseases. | Nazmul Huda Gang Liu Honghai Hong Shengmin Yan Bilon Khambu Xiao-Ming Yin | 2019 | World Journal of Gastroenterology2019，25，34： | 3 |
| 5 | Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi(Ebenaceae)显示文摘Objective: To investigate the comparative effects of Diospyros blancoi(Ebenaceae)leaves(DBL), root bark(DBRB) and stem bark(DBSB) on free radicals and cancer.Methods: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, respectively.Results: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed(95.760 ± 0.343)% and(67.460 ± 2.641)%scavenging with IC50of(3.10 ± 0.17) and(50.00 ± 3.11) mg/m L, respectively. The IC50 values of standard butylated hydroxytoluene and catechin(CA) for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were(8.50 ± 0.25) and(75.00 ± 0.14) mg/m L,respectively suggesting that DBSB had a significant(P < 0.05) radical scavenging activity than standards. In lipid peroxidation inhibition assay, the inhibitory activity of the extracts and the standard was in the following order: DBSB > DBRB > CA > DBL.Also, the phenolic [(139.91 ± 3.924) mg gallic acid equivalent/g] and flavonoid contents[(412.00 ± 16.70) mg catechin equivalent/g)] of DBSB were higher than that of other extracts. In addition, the DBSB showed the moderate cytotoxic and anticancer properties.Conclusions: Our results indicate that Diospyros blancoi stem bark had the significant highest antioxidant and free radical scavenging properties as well as moderate anticancer activity.Hence, we assume that the anticancer activity of this plant can be, at least in part, attributed to its content in phenolic compounds as well as its significant free radical scavenging properties. | Muhammad Ali Khan Mahbubur Rahman Nazmul Sardar Saiful Islam Arman Badrul Islam Jahangir Alam Khandakar Mamunur Rashid Golam Sadik AHM Khurshid Alam | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，5： | 3 |
| 6 | Characterization, prevalence and antibiogram study of Staphylococcus aureus in poultry显示文摘Objective: To reveal the presence of methicillin resistant Staphylococcus aureus(S. aureus)(MRSA) in poultry samples and to determine the antibiogram pattern against five antibiotics.Methods: Samples from different poultry farm of Chittagong city, Bangladesh were examined for S. aureus by different biochemical tests and confirmed as MRSA by identifying the presence of mec A gene using PCR. Antibiotic resistance pattern in S. aureus was determined by antibiotic disk diffusion method.Results: In this study, a total of 60 samples(30 from nasal swabs and 30 from cloacal swabs) were used, of which 54 were confirmed as S. aureus by different biochemical tests. Among these, 12 were confirmed as MRSA by detecting mec A gene using PCR.During antibiogram study, both nasal and cloacal samples showed the highest resistance against penicillin-G and the lowest resistance was observed against neomycin.Conclusions: Based on the present study, it can be said that different antibiotics are used extensively in poultry that leads to MRSA and is alarming for human health. | Yeasmeen Ali Md.Ashraful Islam Nazmul Hasan Muzahid Mohd.Omar Faruk Sikder Md.Amzad Hossain Lolo Wal Marzan | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 2 |
| 7 | Modeling and forecasting exchange rate volatility in Bangladesh using GARCH models:a comparison based on normal and Student's t-error distribution显示文摘Background:Modeling exchange rate volatility has remained crucially important because of its diverse implications.This study aimed to address the issue of error distribution assumption in modeling and forecasting exchange rate volatility between the Bangladeshi taka(BDT)and the US dollar($).Methods:Using daily exchange rates for 7 years(January 1,2008,to April 30,2015),this study attempted to model dynamics following generalized autoregressive conditional heteroscedastic(GARCH),asymmetric power ARCH(APARCH),exponential generalized autoregressive conditional heteroscedstic(EGARCH),threshold generalized autoregressive conditional heteroscedstic(TGARCH),and integrated generalized autoregressive conditional heteroscedstic(IGARCH)processes under both normal and Student’s t-distribution assumptions for errors.Results and Conclusions:It was found that,in contrast with the normal distribution,the application of Student’s t-distribution for errors helped the models satisfy the diagnostic tests and show improved forecasting accuracy.With such error distribution for out-of-sample volatility forecasting,AR(2)–GARCH(1,1)is considered the best. | S.M.Abdullah Salina Siddiqua Muhammad Shahadat Hossain Siddiquee Nazmul Hossain | 2017 | Financial Innovation2017，3，1： | 2 |
| 8 | Regularization of inverse problems in reinforced concrete fracture显示文摘 | Nazmul L M Matsumoto | 2008 | Journal of Engineering Mechanics2008，134，10： | 1 |
| 9 | Arsenic exposure and adverse health effects: A review of recent findings from arsenic and health studies in Matlab, Bangladesh显示文摘 | Mohammad Y Nazmul S Samar K H | 2011 | The Kaohsiung Journal of Medical Sciences2011，27，9： | 1 |
| 10 | Chromatographic study of sorption and diffusion in 4A zeolite显示文摘 | Nazmul H Ruthven D M | 1986 | J Colloid Interf Sci1986，112，1： | 1 |
| 11 | Exosomes from plasmacytoma cells as a tumor vaccine 显示文摘 | Ahieri SL Khan A Nazmul H | 2004 | J Immunother2004，27，4： | 1 |
| 12 | Phase -selectivesynthesis of a silicoaluminophosphate molecular sieve from drygels显示文摘 | NAZMUL Abedin Khan JUNG Hwa Park | 2010 | Materials Research Bulletin2010，45，： | 1 |
| 13 | ISLAMIC NON-GOVERN MENT ORGANISATIONS IN BANGLADESH WITH REF ERENCE TO THREE CASE STUDIES显示文摘 | Kalimullah Nazmul Ahsan | 1990 | Islamic Quar terly1990，，2： | 1 |
| 14 | Dynamic seals lower life costs of wastewater pumps 显示文摘 | Nazmul Zaman | 2004 | Sealing Technology2004，，8： | 1 |
| 15 | Velocity-depth trends in Mesozoic and Cenozoic sediments from the Norwegian Shelf显示文摘 | Vidar Storvoll Knut Bjrlykke and Nazmul H M ondol | 2005 | AAPG Bull2005，89，3： | 1 |
| 16 | Incremental value of natriuretic peptide measurement in acute decompensated heart failure (ADHF): a systematic review显示文摘 | Pasqualina L. Santaguida Andrew C. Don-Wauchope Usman Ali Mark Oremus Judy A. Brown Amy Bustamam Stephen A. Hill Ronald A. Booth Nazmul Sohel Robert McKelvie Cynthia Balion Parminder Raina | 2014 | Heart Failure Reviews2014，，： | 1 |
| 17 | 显示文摘 | Nazmul Abedin Khan Zubair Hasan Sung Hwa Jhung | 2013 | Journal of Hazardous Materials2013，244，15： | 1 |
| 18 | High tempera-ture ferromagnetism in GaAs-based heterostructures withMn & doping 显示文摘 | Nazmul A M Amemiya T Shuto Y | 2005 | Phys Rev Lett2005，95，01： | 1 |
| 19 | Integrated effects of organic, inorganic and biological amendments on methane emission, soil quality and rice productivity in irrigated paddy ecosystem of Bangladesh : field study of two consecutive rice growing seasons显示文摘 | Muhammad Aslam AU M A Sattar M Nazmul Islam | 2014 | Plant and Soil2014，378，12： | 1 |
| 20 | Toshioml Y , Sheyla L R , et al , Global and local neural network models in biotechnology : application to different cultivation processes 显示文摘 | Nazmul K M | 1997 | J Ferment Bioeng1997，83，1： | 1 |
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