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| 1 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 2 | Sudden death in youngcompetitiveathletes:clinicopathologic correlationsin22cases显示文摘 | Corrado D Thiene G Nava A | 1990 | AmJMed1990，89，： | 1 |
| 3 | Thermal behavior ofunsaturated polyester resins +poly (3-octylthiophene) 显示文摘 | MASEGOSA R M NAVA D GARCIA S | 2002 | Thermochim Acta2002，385，： | 1 |
| 4 | Function and specificity of Hox genes显示文摘 | Foronda D Navas L F Garaulet D L | 2009 | Int J Dev Biol2009，53，： | 1 |
| 5 | Assessment of a molten salt heat transfer fluid in parabolic trough solar field显示文摘 | Kearney D Herrmann U Nava P | 2003 | J Sol Energy Eng2003，125，2： | 1 |
| 6 | Thermal propertiesand interactions on blends of poly (ε-caprolactone) with unsaturatedpolyester resin 显示文摘 | NAVA D SALOM C PROLONGO M G | 2003 | J Mate Proecess Tech2003，，： | 1 |
| 7 | Sudden death inyoung competitive athletes : clinicopathologic correlations in 22 ca-ses显示文摘 | CORRADO D THIENE G NAVA A | 1990 | Am J Med1990，89，5： | 1 |
| 8 | Right ventricular cardiomyopathy and sudden death in young people 显示文摘 | Thiene G Nava A Corrado D | 1988 | N Engl J Med1988，318，： | 1 |
| 9 | Right ventricularcardiomyopathy and sudden death in young people显示文摘 | THIENE G NAVA A CORRADO D | 1988 | N Engl JMed1988，318，3： | 1 |
| 10 | Behaviour of reference electrodes in the monitoring of corrosion potential at high temperature显示文摘 | Navas M Gomez Briceno M D | 1997 | Nuclear Engineering and Design1997，168，1： | 1 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy:current diagnostic and management strategies显示文摘 | CORRADO D BASSO C NAVA A et a1 | 2001 | Cardiol Rev2001，9，5： | 1 |
| 12 | Regulation of a transcription factor network required for differentiation and metabolism显示文摘 | Duncan SA Navas MA Dufort D | 1998 | Science1998，281，： | 1 |
| 13 | Effects of some excita- tory amino acid antagonists on imipenem-induced seizures in DBA/2 mice显示文摘 | De Sarro G Ammendola D Nava F | 1995 | Brain Res1995，671，1： | 1 |
| 14 | Familial cardiomyopathy underlies syndrome of right bundle branch block,ST segment elevation and sudden death显示文摘 | Corrado D Nava A Buja G | 1996 | Coli Cardiol1996，27，2： | 1 |
| 15 | Aflatoxin MI and ochratoxin A in a human milk bank in the city of Sao Paulo, Brazil 显示文摘 | NAVAS S A SABINO M RODRIGUEZ-AMAYA D B | 2005 | Food Addit Contam2005，22，5： | 1 |
| 16 | Novel magnetic materials preparedby electrodeposition techniques: arrays of nanowires and multilayered microwires 显示文摘 | Pirota K R Navas D | 2004 | Alloys and Compounds2004，369，： | 1 |
| 17 | Inflammatory cytokines in the tears of patients with ocular rosacea显示文摘 | Barton K Monroy D C Nava A | | 0，，11： | 1 |
| 18 | The impact of fireworks on airborne particles显示文摘 | Roberta Vecchi Vera Bernardoni Diana Cricchio Alessandra D’Alessandro Paola Fermo Franco Lucarelli Silvia Nava Andrea Piazzalunga Gianluigi Valli | 2007 | Atmospheric Environment2007，，6： | 1 |
| 19 | Niobium doping and dielectric anomalies in bismuth titanate显示文摘 | HOLLY S S DRAGAN D NAVA S | 2000 | J Am Ceram Soc2000，83，3： | 1 |
| 20 | Metal-metal interactions across symmetrieal bipyridyl bridging ligands in binuclear seventeen-electron molybdenum complexes 显示文摘 | Amitava Das John P Maher Jon A McCleverty Jon A Navas Badiola Michael D Ward | 1993 | Chem Soc1993，60，： | 1 |
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