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| 1 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 2 | Surface effects on the vibrational frequency of double-walled carbon nanotubes using the nonlocal Timoshenko beam model显示文摘 | Lei X.W Natsuki T Shi J.X Ni Q.Q | | 0，，： | 1 |
| 3 | Aqueous two-phase extraction of nickel dimethylglyoximato complex and its application to spectrophotometric determination of nickel in stainless steel 显示文摘 | Nobutaka Yoshikuni Takayuki Baba Natsuki Tsunoda et al | 2005 | Talanta2005，66，： | 1 |
| 4 | Stiffness and vibration characteristics of SMA/ER3 composites with shape memory alloy short fibers显示文摘 | Qing-Qing Ni Run-xin Zhang Toshiaki Natsuki Masaharu Iwamoto | 2006 | Composite Structures2006，，4： | 1 |
| 5 | Outcome of Treatment for Spinal Metastases Using Scoring System for Preoperative Evaluation of Prognosis显示文摘 | Yasuaki Tokuhashi Yasumitsu Ajiro Natsuki Umezawa | 2009 | Spine2009，，1： | 1 |
| 6 | Minireview mechanical properties of carbon nanomaterials 显示文摘 | HIYASHI T KIM Y A NATSUKI T | 2007 | ChemPhysChem2007，8，7： | 1 |
| 7 | Wave propagation of carbon nanotubes embedded in an elastic medium 显示文摘 | Natsuki T Hayashi T Endo M | 2005 | Journal of Applied Physics2005，97，： | 1 |
| 8 | Optimum temperature of rearing water during artificial induction of ovulation in Japanese eel 显示文摘 | TATSUYA U SAYUMI S NATSUKI H | 2012 | Aquaculture2012，，： | 1 |
| 9 | Microstructure analysis of sintered Nd-Fe-B magnets improved by Tb-Vapor Sorption 显示文摘 | Natsuki Watanabe Masaru Itakura Noriyuki Kuwano | 2007 | Materials Transactions2007，48，5： | 1 |
| 10 | Aqueous two - phase extraction of nickel dim- ethylglyoximato complex and its application to speetro- photometric determination of nickel in stainless steel 显示文摘 | Nobutaka Yoshikuni Takayuki Baba Natsuki Tsuno- da | 2005 | Talanta2005，，66： | 1 |
| 11 | Analysis of the vibration characteristics of double-walled carbon nanotubes显示文摘 | NATSUKI T NI Q ENDO M | 2008 | Carbon2008，46，12： | 1 |
| 12 | Sample available-bandwidth estimation for TCP in wired-wireless network:Per-formance evaluation of web document transmission显示文摘 | Natsuki ltaya Shoji Kasahara Kenji Sugimoto | 2002 | Instituteof Electronics Information and Communication Engineers2002，102，694： | 1 |
| 13 | Evaluation of insulin secretion of isolated rat islets cultured in extra cellular matrix显示文摘 | Natsuki N Yuanjun G Hiroshi H | 2001 | Cell Transplantation2001，32，10： | 1 |
| 14 | Transient stability output margin estimation based on the energy function method显示文摘 | Miwa Natsuki Tanaka Kazuyuki | | 0，，3： | 1 |
| 15 | Synthesis and characterization of highly substituted deoxyfluorocellulose acetate显示文摘 | Kasuya Natsuki Liyama Kenji Ishizu Atsushi | 1992 | Carbonhydro Res1992，230，： | 1 |
| 16 | The relationship be- tween the consumption of meat, fat, and coffee and the risk of colon cancer: A prospective study in Japan 显示文摘 | Shino Oba Natsuki Shimizu Chisato Nagata | 2006 | Cancer Letters2006，244，2： | 1 |
| 17 | A study on Radiometric Calibration of Next Generation Spacebome SAR显示文摘 | Uoshihisa Hara Chikako Ohno Masafumi Iwamoto Natsuki Kondo | 1997 | IEEE International Geoscience and Remote Sensing Symposium1997，3，： | 1 |
| 18 | Sentinel Node Detection Method Using Contrast-Enhanced Ultrasonography with Sonazoid in Breast Cancer: Preliminary Clinical Study显示文摘 | Kiyoka Omoto Hiroaki Matsunaga Natsuki Take Yasuo Hozumi Megumi Takehara Yawara Omoto Mikio Shiozawa Hirobumi Mizunuma Hiroki Harashima Nobuyuki Taniguchi Mikihiko Kawano | 2009 | Ultrasound in Medicine & Biology2009，，8： | 1 |
| 19 | Topographic pattern of the rearrangement of the dystrophin gene in Japanese Duchenne muscular dystrophy显示文摘 | Natsuki Imoto Tadao Arinami Kenzo Hamano Kiichiro Matsumura Hiroki Yamada Hideo Hamaguchi Hitoshi Takita | 1993 | Human Genetics1993，，6： | 1 |
| 20 | Mechanical properties of composites filled with SMA particles and short fibers显示文摘 | Zhang R X Ni Q Q Natsuki T | 2007 | Composite Structure2007，79，1： | 1 |
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