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| 1 | Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies显示文摘AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury. | Mohammed Ibrahim Mohammed Nane Khaja Anjum Aara Aleem Ahmed Khan Mohammed Aejaz Habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor Mohammed Habibullah | 2008 | World Journal of Gastroenterology2008，14，16： | 24 |
| 2 | α1 and β1 integrins enhance the homing and differentiation of cultured prostate cancer stem cells显示文摘CD133+ 前列腺癌症干细胞(PCSC ) 最近在人的前列腺癌症纸巾被识别了。现在的学习在 vitro 在 PCSC 的 homing 和区别报导前列腺癌症祖先房间和伪 1 和尾 1 integrins 的角色的 integrin 侧面。PCSC 与前列腺癌症和表面 integrins 的表示从病人的织物标本被孤立,粘附模式是坚定的。我们表面 integrins 的表示和他们干细胞从前列腺癌症纸巾导出的前列腺癌症的粘附模式的分析表明尾 1 和伪 2 尾 1 integrins 的层次显著地更高(P < 0.05 ) 比那些另外的 integrins。由对比,从前列腺癌症病人的外部导出血的 CD133+ 房间显示出表示的高水平(P < 0.01 )伪 2 尾 1,伪 v 尾 3,伪 v 尾 5,尾 1 和伪 1 integrins 和伪 4 尾 1 integrins 的最小的表情。而且, CD133+ 房间源于两件前列腺癌症织物,外部血展出了附件的增加的度到细胞外的矩阵蛋白质(P < 0.001 ) 并且伪 2 尾 1 integrin 的高表示水平。在用堵住的 vitro 实验,抗体显示伪 1 和尾 1 integrins 在 PCSC 的 homing 和区别有一个角色。这是第一份报告在调停建议 integrins 的重要性 PCSC 的 homing 和区别。 | Satyanarayana Rentala Prameela Devi Yalavarthy Lakshrni Narasu Mangamoori | 2010 | Asian Journal of Andrology2010，12，4： | 2 |
| 3 | Production of Podophynotoxin from Podophyllum hexandrum: a potential natural product for clinically useful anticancer drugs 显示文摘 | Girl A Narasu M L | 2000 | Cytotechnology2000，，： | 1 |
| 4 | Production of podophyllotoxin from Podophyllum hexandrum: a potential natural product for clinically useful anticancer drugs 显示文摘 | Girl A Narasu M L | 2000 | Cytotechnology2000，34，： | 1 |
| 5 | Isolation of cinnamoyl CoA reductase and cinnamyl alcohol dehydrogenase gene promoters from Leucaena leucocephala , a leguminous tree species, and characterization of tissue-specific activity in transgenic tobacco显示文摘 | S. Prashant M. Sri Lakshmi Sunita V. L. Sirisha V. Vijaya Bhaskar A. Maruthi Rao M. Lakshmi Narasu P. B. Kavi Kishor | 2012 | Plant Cell Tissue and Organ Culture (PCTOC)2012，，3： | 1 |
| 6 | Current status of artemisinin and its derivatives as antimalarial drugs显示文摘 | DHINGRA V VISHWESHWAR RAO K LAKSHMI NARASU M | 2000 | Life Sci2000，66，： | 1 |
| 7 | Current status of artemisinin and its derivatives as antimalarial drugs 显示文摘 | Dhingra V Ran VM Narasu L | 2000 | Life Sci2000，66，3： | 1 |
| 8 | Congenital bile duct cysts:classification,operative procedures,and review of thirty-seven cases including cancer arising from choledochal cyst显示文摘 | Todani T Watanabe Y Narasue M | 1977 | Am J Sury1977，134，2： | 1 |
| 9 | Development and validation of a HPLC method for simultaneous quantitation of gatifloxacin, sparfloxacin and moxifloxacin using levofloxacin as internal standard in human plasma application to a clinical pharmacokinetic study显示文摘 | Srinivas N Narasu L Shankar B P | 2008 | Biomed Chrom2008，22，11： | 1 |
| 10 | Transgenic hairy roots: recent trends and applica-tions显示文摘 | Giri A Narasu M L | 2000 | Biotechnol Adv2000，18，1： | 1 |
| 11 | Antimicrobial activity of artemisinin and its precursors显示文摘 | Dhingra V Pakki S R Narasu M L | 2000 | Current Science2000，78，6： | 1 |
| 12 | Artemisinin:present status and perspectives显示文摘 | DHINGRA V RAO K M NARASU L | 1999 | Biochemical Education1999，27，2： | 1 |
| 13 | Transgenic hairy roots: recent trends and applications显示文摘 | Giri A Narasu ML | 2000 | Biotechnol Adv2000，18，1： | 1 |
| 14 | Polyphenolies profile, antiox- idant and radical scavenging activity of leaves and stem of Rapha- nus sativus L显示文摘 | Beevi SS Narasu ML Gowda BB | 2010 | Plant Foods Hum Nutr2010，65，1： | 1 |
| 15 | Current status of artemisinin and its derivatives as antimalarial drugs 显示文摘 | DHINGRA V VISHWESHWAR R K NARASU M L | 2000 | Life Sci2000，66，4： | 1 |
| 16 | Current status of artemisinin and its derivatives as antimalarial drugs显示文摘 | Dhingra V R V Narasu L | 2000 | Life Sci2000，66，3： | 1 |
| 17 | Transgenic hairy roots: recent trends and applications 显示文摘 | Giri A Narasu M L | 2000 | Biotechnol Adv2000，18，： | 1 |
| 18 | Use of Saccharum spontaneum (wild sugarcane)as biomaterial for cell immobilization and modulated ethanol production by thermotolerant Saccharomyces cerevisiae VS3 显示文摘 | CHANDEL A K NARASU M L CHANDRASEKHAR G | 2009 | Bioresource Technology2009，100，8： | 1 |
| 19 | Production of podophyllotoxin from Podophyllum hexandrum: a potential natural product for clinical useful anticancer drugs 显示文摘 | Giri A Narasu ML | 2000 | Cytotechnology2000，34，2： | 1 |
| 20 | Current status of artemisinina and its derivatives as antimalarial clings显示文摘 | Dhingra V Rao K V Narasu M L | 2000 | Life Sci2000，66，4： | 1 |
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