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| 1 | Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma显示文摘AIM: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modifi ed Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm^2, which was used as a cut-off value. MVC was not signif icantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox’s multivariateanalysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic fi nding and hepatic dysfunction. Signifi cant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2. | Atsushi Nanashima Toshiyuki Nakayama Yorihisa Sumida Takafumi Abo Hiroaki Takeshita Kenichirou Shibata Shigekazu Hidaka Terumitsu Sawai Toru Yasutake Takeshi Nagayasu | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 2 | Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score显示文摘AIM: To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score (mJIS).METHODS: We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy.RESULTS: Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group (P < 0.05). The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a mJIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower.CONCLUSION: According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC. | Atsushi Nanashima Junichi Masuda Satoshi Miuma Yorihisa Sumida Takashi Nonaka Kenji Tanaka Shigekazu Hidaka Terumitsu Sawai Takeshi Nagayasu | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 3 | A case of intrahepatic clear cell cholangiocarcinoma显示文摘Intrahepatic clear cell cholangiocarcinoma is very rareonly 8 cases have been reported.A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging,and hepatic segmentectomy was performed.Histopathologically,the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests.These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma.Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen,not mucin nor lipid.On immunohistochemical staining,cytokeratin(CK)7 and CK19 were positive,whereas CK20 was negative.Vimentin was detected on the cell membranes,and CD56 was focally positive.The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively.Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown. | Eo Toriyama Atsushi Nanashima Hideyuki Hayashi Kuniko Abe Naoe Kinoshita Shunsuke Yuge Takeshi Nagayasu Masataka Uetani Tomayoshi Hayashi | 2010 | World Journal of Gastroenterology2010，16，20： | 2 |
| 4 | High expression of trimethylated histone H3 at lysine 27 predicts betterprognosis in non-small cell lung cancer显示文摘 | Xiaohui Chen Ning Song Keitaro Matsumoto Atsushi Nanashima Takeshi Nagayasu Tomayoshi Hayashi Mingang Ying Daisuke Endo Zhiren Wu Takehiko Koji | 2013 | International Journal of Oncology2013，，5： | 2 |
| 5 | Significant of factors in liver metastatic tumors originating from colorectal cancers显示文摘 | Nanashima A Ito M Sekine I | 1998 | Dig Dis Sci1998，43，： | 1 |
| 6 | Usefulness and applica- tion of the liver hanging maneuver for anatomical liver resec- tions显示文摘 | Nanashima A Sumida Y Abo T | 2008 | World J Surg2008，32，： | 1 |
| 7 | NX-PVKA levels before and after hepatectomy of hepatocellular carcinoma as predictors of patient survival:a preliminary evaluation of an improved assay for PIVKA-Ⅱ显示文摘 | Nanashima A Abo T Taura N | 2013 | Anticancer Res2013，33，6： | 1 |
| 8 | Relationship between CT volumetry and functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization before major hepatectomy:a preliminary study显示文摘 | Nanashima A Yamaguchi H Shibasaki S | 2006 | Dig Dis Sci2006，51，10： | 1 |
| 9 | Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients 显示文摘 | Nakagoe T Nanashima A Sawai T | 2000 | J Cancer Res Clin Oncol2000，126，7： | 1 |
| 10 | Clinical significance of microvessel count in patients with metastatic liver cancer originating from colorectal carcinoma 显示文摘 | Nanashima A Shibata K Nakayama T | 2009 | Ann Surg Oncol2009，16，8： | 1 |
| 11 | Decrease of telomeres and increase of interstitial telomeric sites in chro- mosomesf short-term cultured gastric carcinoma cells de- tected byfluoresence in situ hybridization显示文摘 | Kashima K Nanashima A Yasutake T | 2006 | Anticancer Res2006，26，： | 1 |
| 12 | Fibrosis and Inflammatory Activity in Noncancerous Tissue and Mitotic Index of Cancer Tissue in Patients with Hepatocellular Carcinoma: Relationship to Clinicopathological Factors and Prognosis After Hepatic Resection显示文摘 | Atsushi Nanashima Kenji Tanaka Hiroyuki Yamaguchi Shinichi Shibasaki Shigeyuki Morino Megumi Yoshinaga Terumitsu Sawai Tohru Nakagoe Hiroyoshi Ayabe | 2003 | Digestive Diseases and Sciences2003，，8： | 1 |
| 13 | Clinical significance of measuring urinary sulfated bile acids in adult patients with hepatobiliary diseases显示文摘 | Nanashima A Obatake M Sumida Y | 2009 | Hepatogastroenterology2009，56，90： | 1 |
| 14 | Comparative study of anastomosis in pancreaticogastrostomy and pancreaticojejunostomy after pancreaticoduodenectomy 显示文摘 | Nanashima A Sumida Y Abo T | 2007 | Hepatogastroenterology2007，54，76： | 1 |
| 15 | Prognostic Factors in Hepatic Metastases of Colorectal Carcinoma显示文摘 | Atsushi Nanashima Hiroyuki Yamaguchi Terumitsu Sawai Eiichiro Yamaguchi Hideo Kidogawa Seiji Matsuo Toru Yasutake Takashi Tsuji Masaaki Jibiki Tohru Nakagoe Hiroyoshi Ayabe | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 16 | Three-dimensional fusion images of hepatic vasculature and bile duct used for preoperative simulation before hepatic surgery显示文摘 | Nanashima A Abo T Sakamoto I | | 0，，118： | 1 |
| 17 | Experience of surgical resection for hilar cholangiocareimomns at a Japanese single cancer institute 显示文摘 | Nanashima A Tobinaga S Abo T | 2012 | Hepatogastroenterology2012，59，114： | 1 |
| 18 | Damage of hair follicle stem cells and alteration of keratin expression in external radiation?induced acute alopecia显示文摘 | Nanashima N Ito K Ishikawa T | 2012 | Int J Mol Med2012，30，3： | 1 |
| 19 | Adjuvant photodynamic therapy for bile duct carcinoma after surgery: a preliminary study 显示文摘 | Nanashima A | 2004 | J C astroenterol2004，39，11： | 1 |
| 20 | Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients显示文摘 | NAKAGOE T NANASHIMA A SAWAI T | 2000 | J Cancer Res Clin Oncol2000，126，： | 1 |
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