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| 1 | Oceanic plate subduction history in the western Pacific Ocean:Constraint from late Mesozoic evolution of the Tan-Lu Fault Zone显示文摘The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates. | Guang ZHU Cheng LIU Chengchuan GU Shuai ZHANG Yunjian LI Nan SU Shiye XIAO | 2018 | Science China Earth Sciences2018，61，4： | 38 |
| 2 | Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes显示文摘目的: 现在的学习的目的是观察效果抵抗在在在导出老鼠的 hepatocytes.Methods 的胰岛素敏感度和葡萄糖输出上: 老鼠肝细胞瘤房间线 H4IIE 与有教养、刺激抵抗在; supernant 葡萄糖和肝糖内容被检测。胰岛素受体底层(红外)-1 和 IRS-2,蛋白质激酶 B/Akt,肝糖 synthase kinase-3 (3 (GSK-3p ) , suppress 或表明 3 的 cytokine (SOCS-3 ) ,蛋白质内容,以及磷酸化地位被西方的弄污估计。对 SOCS-3 指导的特定的反感觉 oligodeoxynucleotides 习惯于击倒的 SOCS-3.Results :抵抗素导致了抗胰岛素性,但是在老鼠肝细胞瘤房间的affect 葡萄糖输出没衬里 H4IIE.Resistin 胰岛素的稀释多重效果包括刺激胰岛素的肝糖合成和红外的磷酸化,蛋白质激酶 B/Akt ,象 GSK-3beta.Resistin 一样,处理显著地导致了基因和 SOCS-3 的蛋白质表示,胰岛素发信号的一个已知的禁止者。而且,对 SOCS-3 处理指导的特定的反感觉 oligodeoxynucleotide 阻止了抵抗在从反对胰岛素 action.Conclusion : 主要功能抵抗在在肝上是导致胰岛素 resistance.SOCS-3 感应的可以贡献胰岛素在 H4HE hepatocytes 发信号的调停 resistin 的抑制。 | Feng LIU Tao YANG Bin WANG Min ZHANG Nan GU Jie QIU Hong-qi FAN Chun-mei ZHANG Li FEI Xiao- qing PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，1： | 21 |
| 3 | Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles显示文摘瞄准:在 basaland 上估计 resistin 的行动的效果和机制在老鼠的刺激胰岛素的葡萄糖举起骨胳的肌肉 cells.Methods:老鼠 myoblasts ( L6 ) werecultured 并且区分了进刺激与单个商业 resistin 跟随的 myotubes ( 130 ng/mL , 0-24 h )或从有 resistin-expressingvectors 的 293-T 房间 transfected 的有教养的上层清液( 130 ng/mL , 0-24 h ) .Liquid 焕发数被用来测定[ 3H ]胰岛素敏感的葡萄糖 transporters GLUT4 andGLUT1 的 2-deoxyglucoseuptake .The translocation , 联系synaptosomal 的蛋白质 23 ( SNAP23 )并且充斥蛋白质内容,以及 tyrosinephosphorylation statu 有单个 resistin 或有教养的 supernatantcontaining recombinant resistin 的 L6 myotubes 的处理减少了基础、刺激胰岛素的 2-deoxyglucose 举起 andimpaired 刺激胰岛素的 GLUT4 translocation.While SNAP23 蛋白质内容被减少, noeffects 在 GLUT4 或没有影响它的蛋白质内容,也减少的 insulin-stimulatedIRS-1 酷氨酸 phosphorylation 铺平的 GLUT1 蛋白质内容 Resistin 被注意从有 resistin-expr 的 293-T 房间 transfected 的效果 ofrecombinant resistin Resistin 调整了 IRS-1 功能并且减少响应 SNAP23 mayhave 的 insulin.The downregulated 表示的 GLUT4translocation 和葡萄糖举起部分由 resistin 处理 Theseobservations 热点归因于葡萄糖举起的减少在到肥胖的类型 2 diabetesrelated 的 pathophysiology 的 resistin 的潜在的角色。 | Hong-qi FAN Nan GU Feng LIU Li FEI Xiao-qin PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 4 | An Anthropomorphic Robot Hand Developed Based on Underactuated Mechanism and Controlled by EMG Signals显示文摘When developing a humanoid myo-control hand,not only the mechanical structure should be considered to afford a highdexterity,but also the myoelectric (electromyography,EMG) control capability should be taken into account to fully accomplishthe actuation tasks.This paper presents a novel humanoid robotic myocontrol hand (AR hand Ⅲ) which adopted an underac-tuated mechanism and a forearm myocontrol EMG method.The AR hand Ⅲ has five fingers and 15 joints,and actuated by threeembedded motors.Underactuation can be found within each finger and between the rest three fingers (the middle finger,the ringfinger and the little finger) when the hand is grasping objects.For the EMG control,two specific methods are proposed:thethree-fingered hand gesture configuration of the AR hand Ⅲ and a pattern classification method of EMG signals based on astatistical learning algorithm-Support Vector Machine (SVM).Eighteen active hand gestures of a testee are recognized ef-fectively,which can be directly mapped into the motions of AR hand Ⅲ.An on-line EMG control scheme is established basedon two different decision functions:one is for the discrimination between the idle and active modes,the other is for the recog-nition of the active modes.As a result,the AR hand Ⅲ can swiftly follow the gesture instructions of the testee with a time delayless than 100 ms. | Da-peng Yang~1 Jing-dong Zhao~1 Yi-kun Gu~1 Xin-qing Wang~1 Nan Li~1 Li Jiang~1Hong Liu~(1,2) Hai Huang~3 Da-wei Zhao~41.State Key Laboratory of Robotics and System,Harbin Institute of Technology,Harbin 150001,P.R.China2.Institute of Robotics and Mechatronics,German Aerospace Center,Munich 82230,Germany3.College of Shipbuilding Engineering,Harbin Engineering University,Harbin 150001,P.R.China4.College of Automation,Harbin Engineering University,Harbin 150001,P.R.China | 2009 | Journal of Bionic Engineering2009，6，3： | 16 |
| 5 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 6 | Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stern cell generation显示文摘 | Xiaoyuan Wei Yueting Chen Yongyu Xu YangZhan Ru Zhang Min Wang Qiuhong Hua Haifeng Gu Fajun Nan Xin Xie | 2014 | Journal of Molecular Cell Biology2014，8，5： | 13 |
| 7 | Laterally Confined Graphene Nanosheets and Graphene/SnO_(2) Composites as High-Rate Anode Materials for Lithium-Ion Batteries显示文摘High-rate anode materials for lithium-ion batteries are desirable for applications that require high power density.We demonstrate the advantageous rate capability of few-layered graphene nanosheets,with widths of 100-200 nm,over micro-scale graphene nanosheets.Possible reasons for the better performance of the former include their smaller size and better conductivity than the latter.Combination of SnO_(2)nanoparticles with graphene was used to further improve the gravimetric capacities of the electrode at high charge-discharge rates.Furthermore,the volumetric capacity of the composites was substantially enhanced compared to pristine graphene due to the higher density of the composites. | Zhiyong Wang Hao Zhang Nan Li Zujin Shi Zhennan Gu Gaoping Cao | 2010 | Nano Research2010，3，10： | 9 |
| 8 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 9 | Resistin-binding peptide antagonizes role of resistin on white adipose tissue显示文摘在脂肪质的 tissue.Methods 在类脂化合物新陈代谢和内分泌的功能上调查 resistin 和resistin有约束力的肽( RBP )的直接效果:在 vitro 有教养、为有 30 ng/mL recombinant 老鼠 resistin 蛋白质( rResistin )的 24 h 孵化或与改变集中的 RBP 联合的老鼠白脂肪质的 tissuewas (lx10^(-12) mol/L , 1x10 ^(-10) mol/L , 1 x10^(-8) mol/L )丰满的酸(船边交货)释放了进媒介的 .Free 被蛋白质分泌物和 TNF 的 mRNA 表示的比色的 kit.Thelevels | Nan GU Shu-ping HAN Li FEI Xiao-qin PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2007 | Acta Pharmacologica Sinica2007，28，2： | 8 |
| 10 | Pathophysiology of chronic pancreatitis induced by dibutyltin dichloride joint ethanol in mice显示文摘AIM: To search for a new chronic pancreatitis model in mice suitable for investigating the pathophysiological processes leading to pancreatic fibrosis.METHODS: The mice were randomly divided into 2 groups(n = 50), control group and model group. The mice in model group were given ethanol(10%) in drinking water after injection of dibutyltin dichloride(DBTC)(8 mg/kg BW) in tail vein. The mice in control group were injected with only solvent into tail vein( 60 % ethanol, 20% glycerine and 20% normal saline) and drank common water. At days 1, 7, 14, 28, and 56 after application of DBTC or solvent, 10 mice in one group were killed at each time point respectively. Blood was obtained by inferior vena cava puncture. The activity of amylase, concentration of bilirubin and hyaluronic acid in serum were assayed. The pancreas was taken to observe the pancreatic morphology by HE staining, and to characterize the pancreatic fibrosis by Masson staining. The expression of F4/80, CD3 and fibronectin(FN) were assayed by immuno-histochemistry or Immunofluorescence technique. Collagen typeⅠ(COL1A1) in pancreas were detected by Western blot. The expression of matrix metalloproteinase-1(MMP-1) and tissue inhibitor of metalloproteinases-1(TIMP-1) m RNA in the pancreas was assessed by real time PCR.RESULTS: DBTC induced an acute edematous pancreatitis within 1 d. The dilated acini, scattered acinar cell necrosis, and inflammatory cells were found at day 7. Extensive infiltration with inflammatory cells following deposition of connective tissue was observed at day 14. At day 28, level of pancreatic fibrosis was aggravated. The pancreatic tissue was replaced by an extended interstitial fibrosis at the end of 2 mo. There was significant difference in the level of amylase, bilirubin and hyaluronic acid in serum between control group and model group(P < 0.05). The level of COL1A1 and FN in pancreas increased. The expression of MMP-1 m RNA in pancreas decreased, but TIMP-1 m RNA increased at model group.CONCLUSION: DBTC joint Ethanol drinking can induce chronic pancreatitis in accordance with the pathophysiological modification of human. DBTC joint Ethanol-induced pancreatitis in mice is an effective and handy experimental method. The model is suitable to study the mechanism of pancreatic fibrosis in chronic pancreatitis. | Hong Zhang Bin Liu Xiao-Fan Xu Ting-Ting Jiang Xiao-Qin Zhang Ying-Li Shi Yu Chen Fang Liu Jie Gu Lin-Jia Zhu Nan Wu | 2016 | World Journal of Gastroenterology2016，22，10： | 8 |
| 11 | Effects of flooding stress on the photosynthetic apparatus of leaves of two Physocarpus cultivars显示文摘We applied under pot-culture conditions and the double-casing pot method to study the characteristics of photosynthetic gas exchange and chlorophyll fluorescence in the leaves of Physocarpus amurensis Maxim(PA) and Physocarpus opulifolius under flooding stress.Our results indicate a significantly higher flooding tolerance of P.opulifolius compared to P.amurensis.Especially in P.amurensis, the limitation of non-stomatal factors played a major role in the advanced stages of flooding stress,observed as a rapid increase of the intercellular CO_2 concentration(C_i) and a decrease of the stomatal limitation value(L_s).The maximal PSII photochemical efficiencies(F_v/F_m) and actual photochemical efficiency(?_(PSII)) in the leaves of P.opulifolius were significantly higher, and the extent of decrease during the flooding process was smaller than in P.amurensis.In addition, the non-chemical quenching(NPQ) in the leaves of P.opulifolius significantly increased from the 10 th day under flooding stress,while the variation of NPQ in the leaves of P.amurensis was much smaller.This indicates that the leaves of P.opulifolius had not only higher PSII photochemical activity, but also improved tolerance to flooding stress, which may be caused by its ability to dissipate excess excitation energy by starting NPQ.At the 16 th day under flooding stress, the PIABSsignificantly decreased with greater extent of decrease than F_v/F_m in the leaves of both Physocarpus,but the decreasing extent of PIABSin P.opulifolius was significantly smaller than in P.amurensis.In the 16 th day under flooding stress, the fluorescence at J and I point(V_J and V_I) in P.amurensis were significantly higher, and the extent of increase in V_J was greater than V_I.However, the variations of V_Jand V_I in the leaves of P.opulifolius were smaller, suggesting that the damage sites of flooding stress to PSII in the leaves of P.amurensis were mainly located in the electron transport process from Q_A at the PSII receptor side to Q_B.Flooding stress reduced the proportion(φ Eo) of luminous energy absorbed by the PSII reaction center for the electron transport following Q_A^-, while the maximum quantum yield(φ Do) of non-photochemical quenching increased.However, the TR_o/RC and ETo/RC in the leaves of P.amurensis decreased accompanied by a dramatic increase of energy(DI_o/RC) from the dissipation in the reaction center.This further indicated that the function of the PSII reaction center in the leaves of P.amurensis was significantly lower than in P.opulifolius. | Huihui Zhang Peng Feng Wei Yang Xin Sui Xin Li Wei Li Rongtao Zhang Siyu Gu Nan Xu | 2018 | Journal of Forestry Research2018，29，4： | 6 |
| 12 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 13 | Corrosion and Cavitation Erosion Behaviors of Two Marine Propeller Materials in Clean and Sulfide-Polluted 3.5% NaCl Solutions显示文摘The corrosion and cavitation erosion behaviors of two main materials for ship propellers, i.e., nickel–aluminum bronze(NAB) and manganese–nickel–aluminum bronze(MAB) were investigated in a clean and sulfide-polluted 3.5%NaCl solutions. The presence of sulfide increased the corrosion damage of both NAB and MAB by rendering the corrosion product film thicker, more porous and less protective. For MAB, the formation of Fe oxides/sulfides within the corrosion product film may reduce the film compactness and responsible for the lower corrosion resistance, compared with NAB. The presence of sulfide caused the occurrence of more severe corrosion on the surface and therefore further enhanced the cavitation erosion damage. Compared with the result in the clean solution, the cavitation–erosion mass loss rate was raised by a factor of about 11.88% for MAB, and 58.6% for NAB. For NAB, the mechanical erosion dominated the damage in the clean solution, while the cavitation erosion synergy made a significant contribution to the overall damage in the sulfide-polluted solution. For MAB, it was the mechanical damage that contributed mainly to the cavitation erosion damage in both solutions. The exfoliation of large-sized κ phase and the cleavage rupture of β phases resulted in lower cavitation erosion resistance of MAB, compared with NAB. | Qi-Ning Song Nan Xu Ye-Feng Bao Yong-Feng Jiang Wei Gu Yu-Gui Zheng Yan-Xin Qiao | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，8： | 6 |
| 14 | Chemical constituents from endophytic fungus Plectosphaerella cucumerina YCTA2Z1 of Cynanchum auriculatum显示文摘Objective: To study the chemical constituents from the Et OAc extract of endophytic fungal Plectosphaerella cucumerina YCTA2 Z1.Methods: The chemical constituents were isolated and purified by silica gel column,Sephadex LH-20,and reverse-phase C-18 column chromatography as well as crystallization.Results: Thirteen compounds were isolated from the EtOAc extract of the fungal strain YCTA2 Z1.Their chemical structures were elucidated according to the spectral evidence.They were identified as caudatin(1),baishouwubenzophenone(2),cynandione B(3),asterbatanoside A(4),p-hydroxyphenethyl-O-β-D-glycoside(5),caffeic acid(6),ferulic acid(7),2,5-dihydroxyacetophenone(8),protocatechuic acid(9),vanillic acid(10),stearic acid(11),azelaic acid(12),and succinic acid(13).Conclusions: It is the first chemical study on endophytic fungi from Cynanchum auriculatum and all the compounds are obtained from the species,the genus,as well as the family Plectosphaerellaceae for the first time. | Xiao-Jie Gu Ke Ren Nan Yao Song Yan Jian-Fei Zhao Xing-Ying Jiang Qi Lian | 2018 | Chinese Herbal Medicines2018，10，1： | 6 |
| 15 | A paradox:Insulin inhibits expression and secretion of resistin which induces insulin resistance显示文摘AIM: To confirm whether insulin regulates resistinexpression and secretion during differentiation of 3T3-L1preadipocytes and the relationship of resistin with insulinresistance both in vivo and in vitro.METHODS: Supernatant resistin was measured duringdifferentiation of 3T3-L1 preadipocytes. L6 rat myoblastsand hepatoma cell line H4IIE were used to confirm thecellular function of resistin. Diet-induced obese ratswere used as an insulin resistance model to study therelationship of resistin with insulin resistance.RESULTS: Resistin expression and secretion wereenhanced during differentiation 3T3-L1 preadipocytes.This cellular differentiation stimulated resistin expressionand secretion, but was suppressed by insulin. Resistinalso induced insulin resistance in H4IIE hepatocytes andL6 myoblasts. In diet-induced obese rats, serum resistinlevels were negatively correlated with insulin sensitivity,but not with serum insulin.CONCLUSION: Insulin can inhibit resistin expressionand secretion in vitro, but insulin is not a major regulatorof resistin in vivo . Fat tissue mass affects insulinsensitivity by altering the expression and secretion ofresistin. | Feng Liu Hong-Qi Fan Jie Qiu Bin Wang Min Zhang Nan Gu Chun-Mei Zhang Li Fei Xiao-Qing Pan Mei Guo Rong-Hua Chen Xi-Rong Guo | 2008 | World Journal of Gastroenterology2008，14，1： | 6 |
| 16 | Quantitative method to determine the regional drinking water odorant regulation goals based on odor sensitivity distribution:Illustrated using 2-MIB显示文摘Taste and odor(T/O) in drinking water often cause consumer complaints and are thus regulated in many countries. However, people in different regions may exhibit different sensitivities toward T/O. This study proposed a method to determine the regional drinking water odorant regulation goals(ORGs) based on the odor sensitivity distribution of the local population. The distribution of odor sensitivity to 2-methylisoborneol(2-MIB) by the local population in Beijing, China was revealed by using a normal distribution function/model to describe the odor complaint response to a 2-MIB episode in 2005, and a 2-MIB concentration of12.9 ng/L and FPA(flavor profile analysis) intensity of 2.5 was found to be the critical point to cause odor complaints. Thus the Beijing ORG for 2-MIB was determined to be 12.9 ng/L. Based on the assumption that the local FPA panel can represent the local population in terms of sensitivity to odor, and that the critical FPA intensity causing odor complaints was 2.5, this study tried to determine the ORGs for seven other cities of China by performing FPA tests using an FPA panel from the corresponding city. ORG values between 12.9 and 31.6 ng/L were determined, showing that a unified ORG may not be suitable for drinking water odor regulations. This study presents a novel approach for setting drinking water odor regulations. | Jianwei Yu Wei An Nan Cao Min Yang Junong Gu Dong Zhang Ning Lu | 2014 | Journal of Environmental Sciences2014，26，7： | 5 |
| 17 | Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome显示文摘Transposable 元素(TE ) 完全不再在相当一时间被看作了垃圾 DNA 自从他们在优核质染色体的多功能的角色的不断的发现。作为最重要、丰富的 TE 之一在人的染色体仍然活跃,算术逻辑单元,一个正弦家庭,证明了它在顺序水平的不可缺少的规章的功能,而是它的空间角色仍然是不清楚的。技术基于 3C (染色体符合构造俘获) 揭示了染色质的神秘三维的结构,并且使在染色体学习远侧的染色质相互作用可能。发现角色 TE 在人的染色体在远侧的规定玩,我们编了新释放 Hi-C 数据, TE 注解, histone 标记注解,和操作关联分析的染色体宽的 methylation 数据,并且发现算术逻辑单元元素的密度与染色质相互作用的水平显示出强壮的积极关联( hESC :r = 0.9, P < 2.2 在 IC 的限制体积。我们以 anisotropy 解释观察并且对几检查 anisotropy 为哪个剩余散布的试穿被发现有能力的很少建模。我们特别地确定蘸的断绝把 IC 的充分各向同性的房顶与它的各向异性的身体分开的模型,而 isotropy-anisotropy 转变的深度从 190 在东南方向增加 ? 在东南的亚洲下面的 km (离开中国的海岸) 到 350 ? 在澳大利亚下面的 km。如果,以局部性的各向异性的异质扔的另一个可接受的模型是有效的在光线采样上的 33 最大的极的大小在东南的亚洲和极的数据的其余部分下面的小体积独立被对待。这个模型在至少下面想象 IC 的几乎各向同性的东方半球到 360 的深度 ? 在 ICB 下面的 km 并且从 18 仅仅抑制各向异性的体积到诺思纬度的范围 ? 敪湵獥吗?? | Zhuoya Gu Ke Jin M. James C. Crabbe Yang Zhang Xiaolin Liu Yanyan Huang Mengyi Hua Peng Nan Zhaolei Zhang Yang Zhong | 2016 | Protein & Cell2016，7，4： | 4 |
| 18 | High-performance flexible perovskite photodetectors based on single-crystal-like two-dimensional Ruddlesden-Popper thin films显示文摘Two-dimensional Ruddlesden-Popper(2DRP)perovskites have attracted intense research interest for optoelectronic applications,due to their tunable optoelectronic properties and better environmental stability than their threedimensional counterparts.Furthermore,high-performance photodetectors based on single-crystal and polycrystalline thin-films 2DRP perovskites have shown great potential for practical application.However,the complex growth process of single-crystal membranes and uncontrollable phase distribution of polycrystalline films hinder the further development of 2DRP perovskites photodetectors.Herein,we report a series of high-performance photodetectors based on single-crystal-like phase-pure 2DRP perovskite films by designing a novel spacer source.Experimental and theoretical evidence demonstrates that phase-pure films substantially suppress defect states and ion migration.These highly sensitive photodetectors show I_(light)/I_(dark) ratio exceeding 3×10^(4),responsivities exceeding 16 A/W,and detectivities exceeding 3×10^(13) Jones,which are higher at least by 1 order than those of traditional mixed-phase thinfilms 2DRP devices(close to the reported single-crystal devices).More importantly,this strategy can significantly enhance the operational stability of optoelectronic devices and pave the way to large-area flexible productions. | Chao Liang Hao Gu Junmin Xia Tanghao Liu Shiliang Mei Nan Zhang Yonghua Chen Guichuan Xing | 2023 | Carbon Energy2023，5，2： | 4 |
| 19 | Interfacial Engineering of NiFeP/NiFe-LDH Heterojunction for Efficient Overall Water Splitting显示文摘In consideration of application prospect of non-noble metallic materials catalysts,the study of exploring more highly effective electrocatalysts has been focused on by researchers.Herein,a novel strategy is employed to construct a heterojunction consisting of metal phosphide Ni_(x)Fe_(y)P and layered double hydroxide(LDH)with graphene oxide(GO)as conductive support.By adjusting the molar ratio of Ni to Fe,a series of heterojunctions with mixed valence state Fe^(δ+)/Fe^(3+)and Ni^(δ+)/Ni^(2+)(δis likely close to 0)redox couples are achieved and strong synergistic effects towards overall water splitting performance are found.The optimized catalyst with a Ni/Fe molar ratio of 0.72:0.33,namely Ni_(0.7)Fe_(0.3)P/LDH/GO,delivers ultra-low overpotentials for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)of 79 and 198 mV at the current density of 10 mA·cm^(-2),respectively.Furthermore,for overall water-splitting practical application,it only requires 1.526 V at 10 mA·cm^(-2)with robust stability,which is superior to most reported electrocatalysts.Experimental results demonstrate the im-proved electronic conductivity,enlarged electrochemically active area and accelerated kinetics together account for the enhanced performance.This work supplies new prospects for the promotion and application of such heterojunction electrocatalysts in overall water splitting. | Xuanyu Long Jiazhi Meng Jiabao Gu Lanqing Ling Qianwen Li Nan Liu Kaiwen Wang Zequan Li | 2022 | Chinese Journal of Structural Chemistry2022，41，4： | 4 |
| 20 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
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