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| 1 | Resected specimen evaluation,anorectal manometry,endoanal ultrasonography and clinical follow-up after STARR procedures显示文摘AIM:To investigate stapled transanal rectal resection (STARR) procedures as surgical techniques for obstructed defecation syndrome (ODS) by analyzing specimen evaluation,anorectal manometry,endoanal ultrasonography and clinical follow-up.METHODS:From January to December 2007,we have treated 30 patients.Fifteen treated with double PPH-01 staplers and 15 treated using new CCS 30 contour.Resected specimen were measured with respect to average surface and volume.All patients have been evaluated at 24 mo with clinical examination,anorectal manometry and endoanal ultrasonography.RESULTS:Average surface in the CCS 30 group was 54.5 cm2 statistically different when compared to the STARR group (36.92 cm2).The average volume in the CCS 30 group was 29.8 cc,while in the PPH-01 it was23.8 cc and difference was statistically significant.The mean hospital stay in the CCS 30 group was 3.1 d,while in the PPH-01 group the median hospital stay was 3.4 d.As regards the long-term follow-up,an overall satisfactory rate of 83.3% (25/30) was achieved.Endoanal ultrasonography performed 1 year following surgery was considered normal in both of the studied groups.Mean resting pressure was higher than the preoperative value (67.2 mmHg in the STARR group and 65.7 mmHg in the CCS30 group vs 54.7 mmHg and 55.3 mmHg,respectively).Resting and squeezing pressures were lower in those patients not satisfied,but data are not statistically significant.CONCLUSION:The STARR procedure with two PPH-01 is a safe surgical procedure to correct ODS.The new Contour CCS 30 could help to increase the amount of the resected tissue without differences in early complications,post-operative pain and in hospital stay compared to the STARR with two PPH-01 technique. | Gabriele Naldini Guido Cerullo Claudia Menconi Jacopo Martellucci Simone Orlandi Nicola Romano Mauro Rossi | 2011 | World Journal of Gastroenterology2011，17，19： | 6 |
| 2 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 3 | Comparison of CT colonography vs. conventional colonoscopy in mapping the segmental location of colon cancer before surgery显示文摘 | Emanuele Neri Francesca Turini Francesca Cerri Lorenzo Faggioni Paola Vagli Gabriele Naldini Carlo Bartolozzi | 2010 | Abdominal Imaging2010，，5： | 3 |
| 4 | Tailored prolapse surgery for the treatment of haemorrhoids and obstructed defecation syndrome with a new dedicated device: TST STARR Plus显示文摘 | Gabriele Naldini Jacopo Martellucci Roberto Rea Stefano Lucchini Michele Schiano di Visconte Angelo Caviglia Claudia Menconi Donglin Ren Ping He Domenico Mascagni | 2014 | International Journal of Colorectal Disease2014，，5： | 2 |
| 5 | Efficient transfer,integration,and sustained long-term expression of the transgene in adult rat brains injected with lentiviral vector显示文摘 | Naldini L Blomer U Gage FH | 1996 | Proc Natl Acad Sci USA1996，92，11： | 1 |
| 6 | Highly effcient and sustained gene transfer in adult neurons with a lentivirus vector 显示文摘 | Blomer U Naldini L Kafri T | 1997 | J Virol1997，71，8： | 1 |
| 7 | Lentiviruses as gene transfer agents for delivery to non -dividing cells 显示文摘 | Naldini L | 1998 | Curr Opin Biotechnol1998，9，5： | 1 |
| 8 | Endometrioid adeno- carcinoma with squamous differentiation arising from ureteral endo- metriosis in a patient with no history of gonadal endometriosis 显示文摘 | Salerno MG Masciullo V Naldini A | 2005 | Gynecol Oneol2005，99，3： | 1 |
| 9 | In vivo gene delivery andstable transduction of nondividing cells by a lentiviral vector 显示文摘 | Naldini L Blomer U Gallay P | 1996 | Science1996，272，5259： | 1 |
| 10 | Oncoretroviral and lentiviralvector-mediated gene therapy显示文摘 | Van den Driessche T Naldini L Collen D | 2002 | Methods Enzymol2002，346，： | 1 |
| 11 | Identification of a functional role for the protease- activated receptor-1 in hypoxic breast cancer cells显示文摘 | Naldini A Filippi I Ardinghi C | 2009 | Eur J Cancer2009，45，3： | 1 |
| 12 | Angiopoietin - 2 TIEs up macrophages in tumor angiogenesis显示文摘 | De Palma M Naldini L | 2011 | Clin Cancer Res2011，17，16： | 1 |
| 13 | FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis显示文摘 | Pauline Andreu Magnus Johansson Nesrine I. Affara Ferdinando Pucci Tingting Tan Simon Junankar Lidiya Korets Julia Lam David Tawfik David G. DeNardo Luigi Naldini Karin E. de Visser Michele De Palma Lisa M. Coussens | 2010 | Cancer Cell2010，，2： | 1 |
| 14 | Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1显示文摘 | Naldini A Carney D H Pucci A | 2000 | Gen Pharmacol2000，35，5： | 1 |
| 15 | In vivo gene delivery and stable transduction of nondividing ceils by a lentiviral vector 显示文摘 | Naldini L Blt:mer U Gallay P | 1996 | Science1996，272，5259： | 1 |
| 16 | In vtvo gene delivery and stable transduetion of nondividing cells by a lentiviral vector 显示文摘 | Naldini L Blomer U Gallay P | 1996 | Science1996，272，5259： | 1 |
| 17 | In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector显示文摘 | Naldini L Blomer U Gallay P | 1996 | Science1996，272，5259： | 1 |
| 18 | Endometrioid adeno- carcinoma with squamous differentiation arising from ureteral endo- metriosis in a patient with no history of gonadal endometfiosis显示文摘 | Salerno MG Masciullo V Naldini A | 2005 | Gynecol Oncol2005，99，3： | 1 |
| 19 | Novel candidate disease for gene therapy: metachromatic leukodystrophy显示文摘 | Biffi A Naldini L | 2007 | Expert Opin Biol Ther2007，7，8： | 1 |
| 20 | Treatment of slow-transit constipation with sacral nerve modulation 显示文摘 | Naldini G Martellucci J Moraldi L | 2010 | Coloreetal Dis2010，12，： | 1 |
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