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| 1 | Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy显示文摘AIM:To investigate and predict enteral nutrition problems after percutaneous endoscopic gastrostomy (PEG). METHODS:We retrospectively analyzed data for 252 out of 285 patients who underwent PEG at our hospital from 1999 to 2008.Enteral nutrition problems after PEG were defined as:(1)patients who required ≥1 mo after surgery to switch to complete enteral nutrition,or who required additional parenteral alimentation continuously;or(2)patients who abandoned switching to enteral nutrition using the gastrostoma and employed other nutritional methods. We attempted to identify the predictors of problem cases by using a logistic regression analysis that examined the patients’backgrounds and the specific causes that led to their problems. RESULTS:Mean age of the patients was 75 years,and in general,their body weight was low and their overall condition was markedly poor.Blood testing revealed that patients tended to be anemic and malnourished.A total of 44 patients(17.5%)were diagnosed as having enteral nutrition problems after PEG.Major causes ofthe problems included pneumonia,acute enterocolitis (often Clostridium difficile-related),paralytic ileus and biliary tract infection.A multivariate analysis identified the following independent predictors for problem cases:(1)enteral nutrition before gastrectomy(a risk reduction factor);(2)presence of esophageal hiatal hernia;(3)past history of paralytic ileus;and(4) presence of chronic renal dysfunction. CONCLUSION:Enteral nutrition problems after PEG occurred at a comparatively high rate.Patient background analysis elucidated four predictive factors for the problem cases. | Shiro Yokohama Masaru Aoshima Yukiomi Nakade Junya Shindo Junichi Maruyama Masashi Yoneda | 2009 | World Journal of Gastroenterology2009，15，11： | 14 |
| 2 | Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice显示文摘AIM: To investigate whether a glucagon-like peptide-1(GLP-1) analogue inhibits nonalcoholic steatohepatitis(NASH), which is being increasingly recognized in Asia, in non-obese mice. METHODS: A methionine-choline-deficient diet(MCD) along with exendin-4(20 μg/kg per day, ip), a GLP-1 analogue, or saline was administered to male db/db mice(non-obese NASH model). Four or eight weeks after commencement of the diet, the mice were sacrificed and their livers were excised. The excised livers were examined by histochemistry for evidence of hepatic steatosis and inflammation. Hepatic triglyceride(TG) and free fatty acid(FFA) content was measured, and the expression of hepatic fat metabolism- and inflammation-related genes was evaluated. Oxidative stress-related parameters and macrophage recruitment were also examined using immunohistochemistry.RESULTS: Four weeks of MCD feeding induced hepatic steatosis and inflammation and increased the hepatic TG and FFA content. The expression of fattyacid transport protein 4(FATP4), a hepatic FFA influxrelated gene; macrophage recruitment; and the level of malondialdehyde(MDA), an oxidative stress marker, were significantly augmented by a 4-wk MCD. The levels of hepatic sterol regulatory element-binding protein-1c(SREBP-1c) m RNA(lipogenesis-related gene) and acyl-coenzyme A oxidase 1(ACOX1) m RNA(β-oxidation-related gene) had decreased at 4 wk and further decreased at 8 wk. However, the level of microsomal triglyceride transfer protein m RNA(a lipid excretion-related gene) remained unchanged. The administration of exendin-4 significantly attenuated the MCD-induced increase in hepatic steatosis, hepatic TG and FFA content, and FATP4 expression as well as the MCD-induced augmentation of hepatic inflammation, macrophage recruitment, and MDA levels. Additionally, it further decreased the hepatic SREBP-1c level and alleviated the MCD-mediated inhibition of the ACOX1 m RNA level. CONCLUSION: These results suggest that GLP-1 inhibits hepatic steatosis and inflammation through the inhibition of hepatic FFA influx and oxidative stress in a non-obese NASH model. | Takaya Yamamoto Yukiomi Nakade Taeko Yamauchi Yuji Kobayashi Norimitsu Ishii Tomohiko Ohashi Kiyoaki Ito Ken Sato Yoshitaka Fukuzawa Masashi Yoneda | 2016 | World Journal of Gastroenterology2016，22，8： | 10 |
| 3 | Is early enteral nutrition in acute pancreatitis dangerous? About 20 patients fed by an endoscopically placed nasogastrojejunal tube显示文摘 | Nakad D Piessevaux H Marot JC | 1998 | Pancreas1998，17，2： | 1 |
| 4 | Dependence of TiO2 nanoparticle preparation methods and annealing temperature on the efficiency of dye-sensitized solar cells显示文摘 | NAKADE S MATSUDA M KAMBE S | 2002 | J Phys Chem B2002，106，10： | 1 |
| 5 | 1 Electroacu- puncture atST-36accelerates colonicmotility and transit in freely moving conscious rats 显示文摘 | IWA M MATSUSHIMA M NAKADE Y eta | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，2： | 1 |
| 6 | Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats显示文摘 | Nakade Y Tsukamoto K Pappas TN | 2006 | Brain Res2006，1111，22： | 1 |
| 7 | Dynamic MC simulation for a-C:H deposition in methane plasma based on subplantation model显示文摘 | MIYAGAWA Y NAKADATE H IKEYAMA M | 2003 | Diamond and Related Materials2003，12，： | 1 |
| 8 | Is early enteral nutrition in acute pancreatitis dangerous about 20 patients fed by an endoscopically placed nasogastrojejunal tube, pancreatitis 显示文摘 | Nakad A Piessevaux H Marot JC | 2004 | BMJ2004，32，8： | 1 |
| 9 | Optimal allocation of heterogeneous workers in a U-shaped production line 显示文摘 | NAKADE K NISHIWAKI R | 2008 | Computers & Industrial Engineering2008，54，3： | 1 |
| 10 | Reversibility of the pulmona- ry function based on the partial flow - volume curve predicts the efficacy of bronchodilator therapy for treating chronic cough 显示文摘 | Nakade Y Fujimura M Ohkura N | 2013 | Intem Med2013，52，18： | 1 |
| 11 | Influence of TiOz nanopartiele size on electron and recombination in dye-sensitized TiO2 solar cell显示文摘 | Nakade S Kubo W | 2003 | J Phys Chem B2003，107，： | 1 |
| 12 | Brine shrimp lethalitytest active constituents and new highly oxygenated seco-pxQziz-aane-type sesquiterpenes from Illicium merrillianum 显示文摘 | Hung JM Nakade K Kondo M | 2002 | ChemPharm Bull2002，50，1： | 1 |
| 13 | JDP2 suppresses adipocyte differentiation by regulating histone acetylation显示文摘 | Nakade K Pan J Yoshiki A | 2007 | Cell Death Differ2007，14，8： | 1 |
| 14 | It early enteral nutrition in acute pancreatitis dangerous? About 20 patients fed by an endoscopically placed nasogastrojejunal tube显示文摘 | Nakad A Piessevaux H Marot JC | 1998 | Pancreas1998，17，2： | 1 |
| 15 | Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells显示文摘 | Tadaaki Yamada Shinji Takeuchi Junya Nakade Kenji Kita Takayuki Nakagawa Shigeki Nanjo Takahiro Nakamura Kunio Matsumoto Manabu Soda Hiroyuki Mano Toshimitsu Uenaka Seiji Yano | 2012 | Clinical Cancer Research2012，，13： | 1 |
| 16 | A standalone RFID indoor positioning system using passive tags显示文摘 | Saab S S Nakad Z S | 2011 | IEEE Transactions on Industrial Electronics2011，58，5： | 1 |
| 17 | Phenytoin at micromolar concentration is an osteogenic agent for human-mandible-derived bone cells in vitro显示文摘 | Nakade O Baylink DJ Lau KHW | 1995 | J Dent Res1995，74，： | 1 |
| 18 | Phenytoin increase marker of osteogenesis for the human species in vitro and in vivo显示文摘 | Law KHW Nakade O Barr B | 1995 | J Clin Endocrinol Metab1995，80，： | 1 |
| 19 | Neuro- trophicactivity of honokiol on the cultures of fetal rat corti- cal neurons 显示文摘 | FukuyamaY Nakade K Minoshima Y | 2002 | Bioorg MedChem Lett2002，12，8： | 1 |
| 20 | Estimating the remaining life of water-treed XLPE cable by V1F voltage withstand tests显示文摘 | Uchid K Kato Y Nakade M | 2001 | Furukawa Review2001，，20： | 1 |
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