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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases显示文摘AIM:To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components. METHODS:We enrolled 81 patients (40 male,41 fe-male) who were diagnosed with fatty liver by ultraso-nographic scan and fulfi lled the inclusion criteria. First anamnesis,anthropometric,clinical,laboratory and imaging features of all participants were recorded and then liver biopsy was performed after gaining consent from patients. Diagnosis of metabolic syndrome was dependent on patients having 3 or more out of 5 risk criteria defined by the WHO. Biopsy specimens were assessed according to Brunt et al's classification. RESULTS:Sixty-nine of the 81 patients had nonalco-holic steatohepatitis (NASH),11 had simple fatty liver and 1 had cirrhosis according to histologic evaluation. Comparisons were made between two groups of NASH patients,those with and without metabolic syndrome. We did not detect statistically significant differences in liver histology between NASH patients with and wit-hout metabolic syndrome. CONCLUSION:NASH can progress without metabolic risk factors or the presence of metabolic syndrome. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep Blylkll | 2009 | World Journal of Gastroenterology2009，15，9： | 12 |
| 3 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 4 | Non-alcoholic steatohepatitis with normal aminotransferase values显示文摘AIM:To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis(NASH)who had normal aminotransferase levels. METHODS:Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study.We compared all nonalcoholic fatty liver disease and NASH cases,according to aminotransferase level,aspartate aminotransferase (AST)/alanine aminotransferase(ALT)ratio and presence of metabolic syndrome. RESULTS:Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels,seven had NASH and two had simple fatty liver. The patients with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome.Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio. CONCLUSION:Aminotransferase levels and AST/ALT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers,all patients with fatty liver should undergo liver biopsy. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep B|y|kl| | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 5 | Understanding Nonverbal Communication Cues of Human Personality Traits in Human-Robot Interaction显示文摘With the increasing presence of robots in our daily life,there is a strong need and demand for the strategies to acquire a high quality interaction between robots and users by enabling robots to understand users’mood,intention,and other aspects.During human-human interaction,personality traits have an important influence on human behavior,decision,mood,and many others.Therefore,we propose an efficient computational framework to endow the robot with the capability of understanding the user’s personality traits based on the user’s nonverbal communication cues represented by three visual features including the head motion,gaze,and body motion energy,and three vocal features including voice pitch,voice energy,and mel-frequency cepstral coefficient(MFCC).We used the Pepper robot in this study as a communication robot to interact with each participant by asking questions,and meanwhile,the robot extracts the nonverbal features from each participant’s habitual behavior using its on-board sensors.On the other hand,each participant’s personality traits are evaluated with a questionnaire.We then train the ridge regression and linear support vector machine(SVM)classifiers using the nonverbal features and personality trait labels from a questionnaire and evaluate the performance of the classifiers.We have verified the validity of the proposed models that showed promising binary classification performance on recognizing each of the Big Five personality traits of the participants based on individual differences in nonverbal communication cues. | Zhihao Shen Armagan Elibol Nak Young Chong | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，6： | 3 |
| 6 | Some Radius Problems Related to a Certain Subclass of Analytic Functions显示文摘For real parameters α and β such that 0≤α<1<β,we denote by S(α,β) the class of normalized analytic functions which satisfy the following two-sided inequality:α | Oh Sang KWON Young Jae SIM Nak Eun CHO H.M.SRIVASTAVA | 2014 | Acta Mathematica Sinica,English Series2014，30，7： | 2 |
| 7 | Coaxial and waveguide microcalorimeters for RF and microwave power standards显示文摘 | Nak Sam Chung Joon Shin H Bayer R Honigbaum | 1989 | IEEE Trans1989，38，2： | 1 |
| 8 | Performance of Tension and Compression Anchors in Weathered soil 显示文摘 | Nak - Kyung Kim | 2003 | Journal of Geotechnical and Geoenviromnental engineering2003，129，12： | 1 |
| 9 | Development of a metal recovery process from Li-ion battery wastes 显示文摘 | Shun Myung Shin Nak Hyoung Kim Jeong Soo Sohn | 2005 | Hydrometallurgy2005，72，： | 1 |
| 10 | Development of a metal recovery process from Li -ion battery wastes显示文摘 | Shun Myung Shin Nak Hyoung Kim Jeong Soo Sohn | 2005 | Hydrometallurgy2005，，79： | 1 |
| 11 | Performance of tension and ompression anchors in weathered soil显示文摘 | Nak Kyung Kim | 2003 | Journal of Geotechnical and Geoenvironmental ·'Engineering ASCE2003，，12： | 1 |
| 12 | Comparison of the use of cabergoline and gonadotrophin to treat primary and secondary anoestrus in bitches显示文摘 | Nak D Nak Y Simsek G | | 0，，05： | 1 |
| 13 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 14 | Lymphocyte subsets and cytokines in ascitic fluid of decompensated cirrhotic patients with and without spontaneous ascites infection显示文摘 | Kiyici M Nak SG Budak F | 2006 | J Gastroenterol Hepatol2006，21，6： | 1 |
| 15 | Antioxidants and free scavenging activity of phellinus baumii (Phellinus of hymenochaetaceae) extracts显示文摘 | Shon MY Kim TH Nak JS | 2003 | Food Chemistry2003，，82： | 1 |
| 16 | The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma显示文摘 | Young-Ae Park Jeong-Won Lee Jung-Joo Choi Hye-Kyung Jeon YoungJae Cho ChelHun Choi Tae-Joong Kim Nak Woo Lee Byoung-Gie Kim Duk-Soo Bae | 2011 | Gynecologic Oncology2011，，： | 1 |
| 17 | Performance of innovative prestressed support earth retention system in urban excavation显示文摘 | Kim Nak Kyung Park Jong Sik Jang Ho Joon | 2005 | Journal of the KGS2005，25，2： | 1 |
| 18 | Inactivated genotype 1 Japaneseencephalitis vaccine for swine 显示文摘 | YangD K Nak J’Kim H H | 2014 | Clinical and ExperimentalVaccine Research2014，3，2： | 1 |
| 19 | Two isoforma of FTZ-F1 messenger RNA: molecular cloning and their expression in trhe frog testis显示文摘 | Nak Nima T Takase M Miural | 2000 | Gene2000，248，12： | 1 |
| 20 | Decentralized formation control for small- scale robot teams with anonymity 显示文摘 | GEUNHO L NAK Y C | 2009 | Moechatronics2009，19，1： | 1 |
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