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| 1 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 2 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 3 | The immunologic and hematopoietic profiles of mesenchymal stem cells derived from different sections of human umbilical cord显示文摘间充质的干细胞(MSC ) 广泛地在 allogeneic 干细胞移植被使用了。我们比较了 immunologic, MSC 的造血的特征源于整个人的脐的绳索(UC ) ,以及从 UC 的不同的节,包括羊膜的膜(AM ) ,沃顿的果冻(WJ ) ,和脐的容器(紫外) 。房间显型被流动 cytometry 检验。淋巴细胞转变测试和混合淋巴细胞反应被执行评估从 UC 导出的 MSC 的免疫调节的活动。cytokines 的 mRNA 表示被即时聚合酶链反应检测。造血的功能被文化 co MSC 学习, CD34 + 房间从绳索血孤立。我们的结果显示出包括 UC 与这四不同的节分开的那 MSC, WJ,紫外,并且 AM 有类似的生物特征。所有 MSC 有多系区别能力并且能区分进造骨细胞, adipocytes,和 chondrocytes。MSC 也以一种剂量依赖者方式禁止了 allogeneic T 房间的增长。cytokines 的相对 mRNA 表示被检验,并且结果显示出比 MSC 的有的更高的 interleukin-6 (IL6 ) , IL11,干细胞因素,和 FLT3 表示从 UC 的特定的节导出的那 UCMSC。当 co 有教养时, CD34 + 房间有高繁殖效率, MSC 源于 UC, UCMSC 在之中是最有效的喂层的不同的节。我们的学习证明 MSC 能与支持特征的类似的 immunomodulation 和造血作用从整个 UC 或 UC 的特定的节被孤立。 | Man Xu Bin Zhan Yuanlin Liu Jin Zhang Hongxia Sheng Rui Shi Li Liao Na Liu Jiangwei Hu Jun Wang Hongmei Ning Ting Liu Yi Zhang Hu Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 4 | Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China显示文摘Norovirus(No V)is a pathogen that commonly causes viral diarrhea in children.Studies indicate that No V recognizes human histo-blood group antigens(HBGAs)as cell attachment factors.In order to explore the correlation between of No V infection and HBGAs,a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. | SUN Xiao Man YAN Xiao Feng HE Zhi Gang Li Jing Xin GUO Ni Jun XU Zi Qian JIN Miao LI Dan Di ZHOU Yong Kang XIE Guang Cheng Pang Li Li ZHANG Qing LIU Na DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，4： | 3 |
| 5 | Differential induction of mRNA for ICAM-1 and slectins in hepatocytes, Kupffer cells and endothelial cell during dndotoxemia 显示文摘 | Essani NA Mcguire GM Manning AM | 1995 | Biochem Biohys Res Commun1995，211，1： | 1 |
| 6 | Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells显示文摘 | Kkot Nim Kang Da Yeon Kim So Mi Yoon Ju Young Lee Bit Na Lee Jin Seon Kwon Hyo Won Seo Il Woo Lee Ha Cheol Shin Young Man Kim Hyun Soo Kim Jae Ho Kim Byoung Hyun Min Hai Bang Lee Moon Suk Kim | 2012 | Biomaterials2012，，19： | 1 |
| 7 | Mechanism of sodium sulfate in promoting selective reduction of nickel laterite ore during reduction roasting process显示文摘 | Man Jiang Tichang Sun Zhiguo Liu Jue Kou Na Liu Shiyuan Zhang | 2013 | International Journal of Mineral Processing2013，，： | 1 |
| 8 | The shape of early persistent slip markings in fatigued 316L steel 显示文摘 | Polak J Kub~na I Man J | 2013 | Materials Science and Engineering2013，564，12： | 1 |
| 9 | Differential induction of mRNA for ICAM-1 and selectins in hepatocytes显示文摘 | Essani NA Mcguire GM Manning AM | 1995 | Kupffer Cells Res Commun1995，211，1： | 1 |
| 10 | Sensor Monitoring Using a Fuzzy Neural Network With all Automatic Structure Constructor显示文摘 | Man Gyun Na Young Rok Sim Kyung Ho Park | 2003 | IEEE TRANSACTIONS ON NUCLEAR SCIENCE2003，50，2： | 1 |
| 11 | Differential induc- tion of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cell during endotoxemia显示文摘 | Essani NA McGuire GM Manning AM | 1995 | Biochem Biohys Res Commun1995，211，1： | 1 |
| 12 | Association between ghrelin and cardiovascular indexes in healthy obese and lean men显示文摘 | Tritos NA Kissinger KV Manning WJ | 2004 | Chn Endocrinol (Oxf)2004，60，1： | 1 |
| 13 | Endotoxin-induced activation of the nuclear transcription factor κB and expression of E-selectin messenger RNA in hepatocytes,kupffer cells and endothelial cells in vivo显示文摘 | Essani NA Mcguire GM Manning AM | 1996 | J Immunol1996，156，8： | 1 |
| 14 | Auto-tuned pid controller using a model predictive control method for the steam generator water level显示文摘 | Man Gyun Na | 2001 | IEEE Transctions on Nuclear Science2001，，： | 1 |
| 15 | Association between ghrelin and cardiovascular indexes in healthy obese and lean men 显示文摘 | Tritos NA Kissinger KV Manning WJ | 2004 | Clin Endocrinol2004，60，1： | 1 |
| 16 | Mechanism of sodium sulfate in promoting selective reduction of nickel laterite ore during reduction roasting process显示文摘 | JIANG Man SUN Ti-chang LILT Zhi-guo KOU Jue LILT Na ZHANG Shi-yuan | 2013 | International Journal of Mineral Processing2013，123，： | 1 |
| 17 | Partial agonism of 5-HT3 receptors:a novel approach to the symptomatic treatment of IBS-D显示文摘 | Moore NA Sargent BJ Manning DD | 2013 | ACS Chem Neurosci2013，4，1： | 1 |
| 18 | Pathways of signal transduction em- ployed by vertebrate Hedgehogs显示文摘 | Riobo NA Manning DR | 2007 | Biochem J2007，403，3： | 1 |
| 19 | Design of a genetic fuzzy controller for the nuclear steam generator water level control显示文摘 | Man Gyun Na | 1998 | IEEE Transaction on Nuclear Science1998，45，4： | 1 |
| 20 | Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz (a)pyrene in female mice 显示文摘 | Man'eheva TA Demidov DV Plotnikova NA | 2011 | Bull Exp Biol Med2011，151，3： | 1 |
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