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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury 显示文摘 | Nosratola D Vaziri Yu-Shang Lee | 2004 | Brain Research2004，995，1： | 1 |
| 3 | African Americans,hypertension and the renin angiotensin system显示文摘African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system(RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans. | Sandra F Williams Susanne B Nicholas Nosratola D Vaziri Keith C Norris | 2014 | World Journal of Cardiology2014，6，9： | 1 |
| 4 | Oxidative stress, renal infiltration of immune cells, and salt- sensitive hypertension: All for one and one for all 显示文摘 | BERNARDO R I NOSRATOLA D V JAIME H A | 2004 | Am J Physiol Renal Physiol2004，286，： | 1 |
| 5 | Association of renal injury with nitric oxide deficiency in aged SHR:Prevention by hypertension control with AT1 blockade显示文摘 | Nosratola D | 2002 | Kidney International2002，62，3： | 1 |
| 6 | Rodrigueziturbe: effect of chronic antioxidant therapy with superoxide dismu- tase-mimetic drug,tempol,on progression of renal disease in rats with renal mass reduction显示文摘 | YASMIR Q ATILIO F NOSRATOLA D | 2009 | Nephron Exp Nephrol2009，112，： | 1 |
| 7 | Effect of Antioxidant Therapy on Blood Pressure and NO Syn thase Expression in Hypertensive Bats 显示文摘 | Nosratola D V Zhenmin N Fariba O | 2000 | Hypertension2000，36，： | 1 |
| 8 | Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia显示文摘 | Christian K Roberts R.James Barnard Kai Hui Liang Nosratola D Vaziri | 2002 | Atherosclerosis2002，，1： | 1 |
| 9 | Downregulation of hepatic lecithin:cholesterol acyltransferase geneexpression in chronic renal failure 显示文摘 | Nosratola D Vaziri Kaihui Liang Johns Parks | 2001 | Kidney International2001，59，： | 1 |
| 10 | Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy显示文摘 | Nosratola DV yaoxian D Zhenmin N | 1997 | Kidney Int1997，52，： | 1 |
| 11 | Salutary Effects of Hemodialysis on Low-Density Lipoprotein Proinflammatory and High-Density Lipoprotein Anti-inflammatory Properties in Patient With End-Stage Renal Disease显示文摘 | Vaziri Nosratola D Navab Kaveh Gollapudi Pavan Moradi Hamid Pahl Madeleine V Barton Cyril H Fogelman Alan M Navab Mohamad | 2011 | Journal of the National Medical Association2011，，6： | 1 |
| 12 | Superoxide dis- mutase, eatalase, glutathione peroxidase and NADPH oxidase in lead - induced hypertension 显示文摘 | NOSRATOLA D V CHING Y L FARBOD F | 2003 | Kidney International2003，63，1： | 1 |
| 13 | Contribution of impaired Nrf2-Keapl pathway to oxidative stress and inflammation in ehrnnie renal failure 显示文摘 | Hyun Ju Kim Nosratola D Vaziri | 2010 | Anz J Physiol Renal Physiol2010，298，： | 1 |
| 14 | Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension显示文摘 | Bernardo Rodr i guez-Iturbe Nosratola D Vaziri | 2006 | Nature Clinical Practice Nephrology2006，2，10： | 1 |
| 15 | Role of AT1 Receptor in regulation of vascular MCP-1,IL-6,PAI-1,MAP Kinase,and matrix expression in obesity显示文摘 | nosratola D Xu | 2005 | Kidney Interational2005，68，6： | 1 |
| 16 | Iron and oxidative stress in renalInsufficiency显示文摘 | Chun Soo Lim Nosratola D Vaziri | 2004 | Am J Nephrol2004，24，： | 1 |
| 17 | Effects of simulated hyperglycemia,insulin,and glucagon on endothelial nitric oxide synthase expression显示文摘 | Yao Xian Ding Nosratola D Vaziri Richard Coulson | 2000 | Am J Physiol Endocrinol Metab2000，279，1： | 1 |
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