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| 1 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 2 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 3 | Antimicrobial resistance among gram-negative organisms in the intensive care unirt显示文摘 | Nina C Jan P Josep L | 2003 | Current opinion in critical care2003，9，： | 1 |
| 4 | Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reper{usion injury显示文摘 | Nina K Andrea C Roberta M | 2011 | Biochim Biophys Acta2011，18，13： | 1 |
| 5 | A plant caspase-like protease activated during the hypersensitive response显示文摘 | NINA V C SANG H K ELENA S T | 2004 | Plant Cell2004，16，： | 1 |
| 6 | Sensitivity of aquatic plant to the herbicide metsulfuron-methyl显示文摘 | Nina C Jens C S Niels H S | 2004 | Ecotoxicology and Environmental Safety2004，57，： | 1 |
| 7 | Degradation products formed during UV-irradiation of humic waters显示文摘 | NINA C PETER B MAARET K | 1996 | Chemosphere1996，33，2： | 1 |
| 8 | Trajectories of perceived emotional and physical distress in patients with an implantable cardioverter defibrillator显示文摘 | Krista C Broek Nina Kupper Pepijn H | 2014 | International Journal of Behavioral Medicine2014，21，： | 1 |
| 9 | Foreign Investment and Income Inequality:The Natural Experiment of Central and Eastern Europe显示文摘 | Matthew C Mahutga Nina Bandelj | | 0，，06： | 1 |
| 10 | Current management of the complications of portal hypertension: variceal bleeding and ascites 显示文摘 | Nina D Frederic O Paul C | 2006 | CMAJ2006，174，10： | 1 |
| 11 | Characteristics of Marketing Channels : A Theoretical Framework 显示文摘 | Nina Michaelidou David C Arnott Sally Dibb | 2005 | The Marketing Review2005，5，： | 1 |
| 12 | Simulation-based education:What's in it for nurse anesthesia educators?显示文摘 | Nina T Cliff R Karl C | 2008 | AANA Journal2008，76，4： | 1 |
| 13 | Expression in Trichoderrna reesei and characterisation of a thermostahle family 3 β-glucosidase from the moderately thermophilic fungus Talaromyces emersonii 显示文摘 | Patrick M Nina A Catherine C | 2004 | Protein Expression and Purification2004，38，： | 1 |
| 14 | Neonatal exchange transfusions in the 21st century:A single hospital study显示文摘 | Helen E C Nina Z Helen S | 2013 | J Paedia Child Health2013，49，10： | 1 |
| 15 | Non-fertile sperm delay female remating显示文摘 | Penny A C Nina W | 1999 | Nature1999，397，： | 1 |
| 16 | Pseudomonas aeruginosa increases forma- tion of multidrug-tolerant persister cells in response to quorum-sensing signa- ling molecules 显示文摘 | Nina M Dea C R Tao J | 2010 | Journal of Bacteriology2010，192，： | 1 |
| 17 | Elucidating Negative ThermalExpansion in MOF-5 显示文摘 | Nina L Yue W Mogens C | 2010 | Journal of Physical Chemistry C2010，114，16： | 1 |
| 18 | Characteristics of capillary pressure curves显示文摘 | DONALDSON E C NINA EWALL BALJIT SINGH | 1991 | Journal of Petroleum Science and Engineering1991，，6： | 1 |
| 19 | The role of molecular size in antioxidant activity of peptide fractions from Pacific hake (Merluccius productus) hydrolysates显示文摘 | IMELDA W Y C LENNIE K Y C NINA Y T | 2012 | Food Chemistry2012，134，3： | 1 |
| 20 | Dynamic meniscus profile method for determination of the dynamic contactangle in the Wilhelmy geometry显示文摘 | Stanimir D Iliev Nina C Pesheva | 2011 | Colloids Surf A:Physicochem Eng Aspects2011，385，13： | 1 |
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