|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Fluid Stochastic Petri Nets: Theory, Applications and Solution 显示文摘 | G Horton V G Kulkami D M Nicol K S Trivedi | 1998 | European Journal of Operations Research (S0377-2217)1998，105，1： | 1 |
| 3 | Acetamin- ophen pharmaeokinetics in children with nonalcohol- ic fatty liver disease显示文摘 | Nicole J Barshop MD Edmund V | 2011 | J Pediatr Gastroenterol Nutr2011，52，2： | 1 |
| 4 | Environmental and stomatal control of transpiration, canopy conductance and decoupling coefficient in young lemon trees under shading net显示文摘 | Nicol 6 s E Barradas V L Ortuno M F Navarro A Torrecilla S A Alarcon J J | 2008 | Environmental and Experimental Botany2008，63，13： | 1 |
| 5 | Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88 显示文摘 | FREMOND CM YEREMEEV V NICOLLE DM | 2004 | J Clin Invest2004，114，12： | 1 |
| 6 | Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi显示文摘 | Christopher S E Jose R V Nicole L S | 2011 | Plos Negl Trop Dis2011，5，3： | 1 |
| 7 | Huid stochastic Petri nets: theory, applications and solution显示文摘 | Horton G Kulkami V G Nicol D Metal | 1998 | European Journal of Operation Research1998，105，1： | 1 |
| 8 | Improving Homogeneity by Dynamic Speed Limit Systems 显示文摘 | Nicole V N Stefan B Divera T | 2010 | Accident Analysis & Prevention (S0001-4575)2010，42，3： | 1 |
| 9 | Polar ocean ecosystems in a changing world显示文摘 | Smetacek V Nicol S | 2005 | Nature2005，437，： | 1 |
| 10 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 11 | GABA generates excitement显示文摘 | Stein V Nicoll R A | 2003 | Neuron2003，37，： | 1 |
| 12 | Internationalization: Conceptualizing an Entrepreneurial Process of Behaviour in Time, Journal of International Business Studies 显示文摘 | Jones Marian V Coviello Nicole E | 2005 | 36 ( 3 ) :284 - 3032005，36，3： | 1 |
| 13 | Fungi parasitic on juveniles and masses of Meloidogyne hapla in organic soils from New york 显示文摘 | Nicole M V George A S | 1998 | Nematodes1998，30，： | 1 |
| 14 | Mobility into tourism refuge employer显示文摘 | Nicole V Rick R (2007) | 2007 | Annals of Tourism Research2007，，： | 1 |
| 15 | Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer 显示文摘 | JOANA C NICOLE C V PATRICIA M | 2012 | J Pathol2012，22，8： | 1 |
| 16 | A new approach to retrain gait in stroke patients through body weight support and treadmill stimulation显示文摘 | Martha V Hugues B Nicol KB | 1998 | Stroke1998，29，： | 1 |
| 17 | Electrochemical oxidation of iron (II) ions on lead alloy anodes 显示文摘 | Tjandrawan V Nicol M J | 2013 | Hydrometallurgy2013，131，： | 1 |
| 18 | Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88显示文摘 | Yeremeev V Nicolle DM | 2004 | J Clin Invest2004，114，12： | 1 |
| 19 | Memory consolidation fi}r contexlual and auditory fear conditioning is dependent on prolein synthesis, PKA, and MAP kinase显示文摘 | Glenn E Schafe Nicole V | 1999 | Learn Mere1999，6，： | 1 |
| 20 | Displacement transfer between intersecting regional strike-slip and extensional fault systems显示文摘 | Mouslopoulou V Nicol A Little T A | 2007 | Journal of Structural Geology2007，29，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员