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| 1 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | The lysine requirement of lactating primiparous sow显示文摘 | TOUCHETTE K J ALLEE G L NEWCOMB M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 4 | Automatic linkage of vital records显示文摘 | NEWCOMBE H B KENNEDY J M AXFORD S J | | 0，，3381： | 1 |
| 5 | IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation显示文摘 | Newcomb D C Boswell M G Reiss S Zhou W Goleniewska K Toki S | 2013 | Thorax2013，68，： | 1 |
| 6 | Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF dependent manner 显示文摘 | GILL Z P PERKS C M NEWCOMB P V | 1997 | J Biol Chem1997，272，25： | 1 |
| 7 | Influence of characterised nature organic material on activated carbon adsorption: effect on pore volume distribution and adsorption of 2-methylisoborneol 显示文摘 | NEWCOMBE G DRIKAS M HAYES R | 1997 | Water Research1997，31，： | 1 |
| 8 | Optimal refresher training intervals for AED and CPRskills:A randomiszd controlled trial显示文摘 | We not reached by toollard M Whitfield R Newcombe RG | 2006 | Resuscitation2006，71，2： | 1 |
| 9 | Cellulase, clostfidia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，69，： | 1 |
| 10 | The lysine requirement of lactating primiparous sows显示文摘 | Touchette K J Allee G L Newcomb M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 11 | J Anim Sci显示文摘 | Touchette K J Allee G L Newcomb M D | 1998 | 76: 10911998，76，： | 1 |
| 12 | Granular activated carbon:importance of surface properties in the adsorption of naturally occurring organics显示文摘 | Newcombe G Hayes R Drikas M | 1993 | Colloids and Surfaces A1993，78，13： | 1 |
| 13 | Cellulase, clostridia, and ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，，69： | 1 |
| 14 | Cor triatriatum:Presentation,diagnosis and long-term surgical results显示文摘 | Alphonso N Norgaard M A Newcomb A | 2005 | Ann Thorac Surg2005，80，5： | 1 |
| 15 | Effect of protein diet on feed intake and body weight gain of broiler and leghorn chicks 显示文摘 | Newcomb M Summers J D | 1984 | Poultry Science1984，63，： | 1 |
| 16 | Endotoxin, sepsis, and the primrose path 显示文摘 | O'Reilly M Newcomb DE Remick D | 1999 | Shock1999，12，6： | 1 |
| 17 | Expression of the cell cycle inhibitor p27 kip1 is a new prognostic marker associated with survival in epithelial ovarian tumors显示文摘 | Newcomb EW Sosnow M Demopoulos RI | 1999 | Am J Pathol1999，154，1： | 1 |
| 18 | Nuclear Fears and Concerns among College-students:A Cross-national-study of Attitudes显示文摘 | Rabow J Hernandez A Newcomb M D | 1990 | Political Psychology1990，11，4： | 1 |
| 19 | Endotoxin, sepsis, and the primrose path显示文摘 | Reily M Newcomb D E Remick D | 1999 | Shock1999，12，6： | 1 |
| 20 | Two different amino acid substitutions in the ali-esterase,E3,confer alternative types of organophosphorus insecticide resistance in the sheep blowfly,Lucilia cuprina显示文摘 | Campbell P M Newcomb R D Russell R J | 1998 | Insect Biochemistry and Molecular Biology1998，，： | 1 |
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