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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | The lysine requirement of lactating primiparous sow显示文摘 | TOUCHETTE K J ALLEE G L NEWCOMB M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 3 | IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation显示文摘 | Newcomb D C Boswell M G Reiss S Zhou W Goleniewska K Toki S | 2013 | Thorax2013，68，： | 1 |
| 4 | Cellulase, clostfidia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，69，： | 1 |
| 5 | The lysine requirement of lactating primiparous sows显示文摘 | Touchette K J Allee G L Newcomb M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 6 | J Anim Sci显示文摘 | Touchette K J Allee G L Newcomb M D | 1998 | 76: 10911998，76，： | 1 |
| 7 | Cellulase, clostridia, and ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，，69： | 1 |
| 8 | Effect of protein diet on feed intake and body weight gain of broiler and leghorn chicks 显示文摘 | Newcomb M Summers J D | 1984 | Poultry Science1984，63，： | 1 |
| 9 | Endotoxin, sepsis, and the primrose path 显示文摘 | O'Reilly M Newcomb DE Remick D | 1999 | Shock1999，12，6： | 1 |
| 10 | Nuclear Fears and Concerns among College-students:A Cross-national-study of Attitudes显示文摘 | Rabow J Hernandez A Newcomb M D | 1990 | Political Psychology1990，11，4： | 1 |
| 11 | Endotoxin, sepsis, and the primrose path显示文摘 | Reily M Newcomb D E Remick D | 1999 | Shock1999，12，6： | 1 |
| 12 | Two different amino acid substitutions in the ali-esterase,E3,confer alternative types of organophosphorus insecticide resistance in the sheep blowfly,Lucilia cuprina显示文摘 | Campbell P M Newcomb R D Russell R J | 1998 | Insect Biochemistry and Molecular Biology1998，，： | 1 |
| 13 | Cellulase, clostridia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol Rev2005，69，： | 1 |
| 14 | Does preoperative atrial fibrillation portend a poorer prognosis in patients undergoing isolated aortic valve replacement- A multicentre Australian study显示文摘 | Saxena A Dinh D T Reid C M Smith J A Shardey G C Newcomb A E | 2013 | Can J Cardiol2013，29，： | 1 |
| 15 | Endotoxi sepsis,and the primrose path显示文摘 | O'Reilly M Newcomb DE Remck D | 1999 | Shock1999，12，6： | 1 |
| 16 | cDNA cloning,baculovirus expression and kinetic properties of the esterase,E3,involved in organophosphorus resistance in Lucilia cupri na显示文摘 | Newcomb R D Campbell P M Russell R J | 1997 | Insect Biochem Mol Biol1997，27，1： | 1 |
| 17 | Endotoxin,sepsis,and the primarily path显示文摘 | Newcomb DE Remick D | 1999 | Shock1999，12，6： | 1 |
| 18 | The effects of sexual partnership and relationship characteristics on three sexual risk variables in young men who have sex with men显示文摘 | Newcomb M E Ryan D T Garofalo R | 2014 | Archives of Sexual Behavior2014，43，1： | 1 |
| 19 | Two different amino acid substitutions in the ali-esterase,E3,confer alternative types of organophosphorus insecticide resistance in the sheep blowfly,Lucilia cuprina显示文摘 | CAMPBELL P M NEWCOMB R D RUSSELL R J | 1998 | Insect Biochemistry and Molecular Biology1998，28，3： | 1 |
| 20 | Cellulase, Clostridia, and Ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiology and Molecular Biology Reviews2005，，： | 1 |
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