|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review显示文摘AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODS:We searched Pub Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,European Neuroendocrine Tumor Society,European Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and octreotide.Bibliographies of accepted articles were also searched.Two reviewers reviewed titles,abstracts,and full-length articles.Studies that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the review.RESULTS:The search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the review.Studies varied in designs,subjects,octreotide-LAR regimens,and definition of outcomes.Eleven studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively measured.Ten studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/mo.Eight studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor progression.Eight studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/mo.CONCLUSION:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET patients.Furthermore,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal symptoms. | Michael S Broder David Beenhouwer Jonathan R Strosberg Maureen P Neary Dasha Cherepanov | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 2 | Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy. | Carthage P Moran Barra Neary Glen A Doherty | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 3 |
| 3 | The Evolving Role of Taurolidine in Cancer Therapy显示文摘 | Peter M. Neary Patrick Hallihan Jiang H. Wang Rolf W. Pfirrmann David J. Bouchier-Hayes Henry P. Redmond | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 4 | 1994, Cost Asymmetries in International Subsidy Game: Shuld Governments Help Winners or Losers?显示文摘 | Neary | 1994 | Journal of International1994，37，： | 1 |
| 5 | Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery显示文摘 | Takacs JE Neary TB Ingolia NT | 2011 | RNA2011，17，3： | 1 |
| 6 | Regional alteration of protein kinase C activity following transient cerebral ischemia:effects of intraischemia brain temperature modulation显示文摘 | Busto R Globus MY Neary JT | 1994 | J Neurochem1994，63，3： | 1 |
| 7 | Dementia of frontal lobe type显示文摘 | Neary D Snowden JS Northen B | 1988 | J Neurol Neurosurg Psychiatry1988，51，3： | 1 |
| 8 | 显示文摘 | Elhadd TA Neary R | 1999 | J Clin Endocrinol Metab1999，84，3： | 1 |
| 9 | Effects of wildfire on soils and watershed processes 显示文摘 | lee G G Neary D G Adams P W | 2004 | Journal of Forestry2004，102，6： | 1 |
| 10 | Fire effects on belowground sustainability~ a review and synthesis显示文摘 | Neary D G Klopatek C C Debano L F | 1999 | Forest Ecology and Management1999，122，： | 1 |
| 11 | Fire effects on belowground sustainability: a review and synthesis 显示文摘 | NEARY D G KLOPATEK C C DEBANO | 1999 | Forest Ecology and Management1999，122，： | 1 |
| 12 | Common variation in the vitamin 0 receptor gene and risk of inflammatory bowel disease in an Irish case-control study显示文摘 | Hughes OJ McManus R Neary P O'morain C O'sullivan M | 2011 | Eu[J Gastroenterol Hepatol2011，23，9： | 1 |
| 13 | Ammonia-induced astrocyte swelling in primary culture显示文摘 | M. D. Norenberg L. Baker L-O. B. Norenberg J. Blicharska J. H. Bruce-Gregorios J. T. Neary | 1991 | Neurochemical Research1991，，7： | 1 |
| 14 | Frontotemporal dementia显示文摘 | Snowden JS Neary D Mann D M | 2002 | Br J Psychiatry2002，180，： | 1 |
| 15 | Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes:involvement of a calcium-independent protein kinase C,extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway显示文摘 | Neary JT Kang Y Bu Y | 1999 | J Neurosci1999，19，： | 1 |
| 16 | Three-dimensional numerical model of lateral-intake inflow 显示文摘 | Neary V S Sotiropoulos F Odgaard A J | 1996 | J Hydr Engrg ASCE1996，125，2： | 1 |
| 17 | Frontotemporal lobar degeneration:a consensus on clinical diagnostic criteria显示文摘 | Neary D Snowden J S Gustafson L | 1998 | Neurology1998，51，： | 1 |
| 18 | Throughfall and stemflow chemistry under deciduous and coniferous forest canopy in south central Ontario显示文摘 | Neary A J Gizyn W I | 1994 | Canadian Journal of Forest Research1994，24，6： | 1 |
| 19 | Transanal endoscopic microsurgery:a viable operative alternative in selected patients with rectal lesions显示文摘 | Neary P Makin GB White TJ | | 0，，09： | 1 |
| 20 | Adrenal insufficiency:etiology,diagnosis and treatment显示文摘 | Neary N Nieman L | 2010 | Curr Opin Endocrinol Diabetes Obes2010，17，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员