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| 1 | Amyloid-β depresses excitatory cholinergic synaptic transmission in Drosophila显示文摘Objective Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to cognitive dysfunctions like Alzheimer's disease (AD). Although amyloid-β (Aβ) aggregation is a pathological hallmark of AD, the mechanisms by which Aβ peptides modulate cholinergic synaptic transmission and memory loss remain obscure. This study was aimed to investigate the potential synaptic modulation by Aβ of the cholinergic synapses between olfactory receptor neurons and projection neurons (PNs) in the olfactory lobe of the fruit fly. Methods Cholinergic spontaneous and miniature excitatory postsynaptic current (mEPSC) were recorded with whole-cell patch clamp from PNs in Drosophila AD models expressing Aβ40, Aβ42, or Aβ42Arc peptides in neural tissue. Results In fly pupae (2 days before eclosion), overexpression of Aβ42 or Aβ42Arc, but not Aβ40, led to a significant decrease of mEPSC frequency, while overexpression of Aβ40, Aβ42, or Aβ42Arc had no significant effect on mEPSC amplitude. In contrast, Pavlovian olfactory associative learning and lifespan assays showed that both short-term memory and lifespan were decreased in the Drosophila models expressing Aβ40, Aβ42, or Aβ42Arc. Conclusion Both electrophysiological and behavioral results showed an effect of Aβ peptide on cholinergic synaptic transmission and suggest a possible mechanism by which Aβ peptides cause cholinergic neuron degeneration and the consequent memory loss. | Liqun Fang Jingjing Duan Dongzhi Ran Zihao Fan Ying Yan Naya Huang Huaiyu Gu Yulan Zhu | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 2 | Tissue-specific regulation of the insulin gene by a novel basle helix-loop-helix transcription facotor显示文摘 | Naya FJ Stellreeht CM Tsai M J | 1995 | Genes Dev1995，15，： | 1 |
| 3 | Laparoscopic adrenalectomy in patients with large adrenal tumors显示文摘 | Naya Y Suzuki H Komiya A | 2005 | Int J Urol2005，12，2： | 1 |
| 4 | Fifty years of experiences with propylthiouracil- associated hepatotoxicity: what have we learn- ed? 显示文摘 | Williams KV Naya S Becker D | 1997 | J Clin Endocrinol Metab1997，82，6： | 1 |
| 5 | Tissue- specific regulation of the insulin gene by a novel basic helix- loop-helix transcription factor显示文摘 | NAYA F J STELLRECHT C M TSAI M J | 1995 | Genes Dev1995，9，8： | 1 |
| 6 | Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice 显示文摘 | Naya F J Huang H P Qiu Y | 1997 | Gene Dev1997，11，18： | 1 |
| 7 | Translational selection shapes codon usage in the GC-rich genomes of Chlamydomonas reinhardtii显示文摘 | Naya H Romero H Carels N | 2001 | FEBS Letters2001，501，23： | 1 |
| 8 | Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction显示文摘 | Iwama H Uemura S Naya N | 2006 | J Am Coll Cardiol2006，47，8： | 1 |
| 9 | Diabetes,defective pancreatic morphogenesis,and abnormal enteroendocrine differentiation in BETA2/neuro D-deficient mice显示文摘 | NAYA F J HUANG H P QIU Y | 1997 | Genes&Development1997，11，18： | 1 |
| 10 | Tumor necrosis factor-alpha neu-tralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia显示文摘 | Hosomi N Ban CR Naya T | 2005 | J Cereb Blood Flow Metab2005，25，： | 1 |
| 11 | MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type显示文摘 | Wu H Naya F J Mc Kinsey T A | 2000 | EMBO J2000，19，9： | 1 |
| 12 | The structure of petasitin a new sequiterpene from Petasites japonicus Maxim 显示文摘 | Naya K Takagz I | 1968 | Tet rahedron Letters1968，5，： | 1 |
| 13 | IGF-I induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1显示文摘 | Musaro A McCullagh K J Naya F J | 1999 | Nature1999，400，6744： | 1 |
| 14 | Plasma interleukin-6 and tumor necrosis factor-alpha can predict coronary endothehal dysfunction in hypertensive patients显示文摘 | Naya M Tsukamoto T Morita K | 2007 | Hypertens Res2007，30，6： | 1 |
| 15 | Functional characterization of an unusual phytochelatin synthase, LjPCS3, of Lotus japonicus 显示文摘 | Ramos J Naya L Gay M | 2008 | Plant Physiology2008，148，： | 1 |
| 16 | Influences of particle size and content of RDX on burning characteristics of RDX- based propellant显示文摘 | Naya T Kohga M | 2014 | Aerospace Science and Technol- ogy2014，32，： | 1 |
| 17 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve显示文摘 | Venkatesh L. Murthy Masanao Naya Courtney R. Foster Jon Hainer Mariya Gaber Gilda Di Carli Ron Blankstein Sharmila Dorbala Arkadiusz Sitek Michael J. Pencina Marcelo F. Di Carli | 2011 | Circulation2011，，： | 1 |
| 18 | Comparative pulmonary toxicity study of nano TiO2 particles of different sizes and agglomerations in rats: different short and long-term post-instillation results显示文摘 | Kobayashi N Naya M Endoh S Maru J Yamamoto K Nakan- ishi J | 2009 | Toxicology2009，264，12： | 1 |
| 19 | Myocardial flow reserve is influenced by both coronary artery stenosis severity and coronary risk factors in patients with suspected coronary artery disease显示文摘 | Tsukamoto T Morita K Naya M | 2006 | Eur J Nucl Med Mol Imaging2006，33，10： | 1 |
| 20 | Plasma interleukin-6 and tumor necrosis factior-alpha can predict coronary endothelial dysfunction in hypertensive patients 显示文摘 | Naya M Tsukamoto T Morita K | 2007 | Hypertens Res2007，30，6： | 1 |
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