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| 1 | Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression显示文摘Hepatotropic viruses induced hepatitis progresses much faster and causes more liver-related health problems in people co-infected with human immunodeficiency virus(HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus(HBV) and hepatitis C virus(HCV) causes significant numbers of non-acquired immune deficiency syndrome(AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals(DAA) and antiretroviral therapy(ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals. | Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2019 | World Journal of Gastroenterology2019，25，4： | 12 |
| 2 | Liver as a target of human immunodeficiency virus infection显示文摘Liver injury is a characteristic feature of human immunodeficiency virus(HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy(ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIV-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIV-infection and liver cells are prominently involved in HIV-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIV, clinical evidence of HIVrelated liver damage, interactions between HIV and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression. | Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2018 | World Journal of Gastroenterology2018，24，42： | 5 |
| 3 | Role of alcohol in pathogenesis of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)and alcohol abuse often contribute to the development of end-stage liver disease.Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically.Importantly,the mechanism by which alcohol promotes the progression of HBVassociated liver disease are not completely understood.Potential mechanisms include a suppressed immune response,oxidative stress,endoplasmic reticulum and Golgi apparatus stresses,and increased HBV replication.Certainly,more research is necessary to gain a better understanding of these mechanisms such that treatment(s)to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed.In this review,we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field. | Murali Ganesan Allison Eikenberry Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2020 | World Journal of Gastroenterology2020，26，9： | 5 |
| 4 | Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids显示文摘Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid(FSL) constructs that can be gently inserted into the virus membrane. We assessed whether labeling with fluorescent(fluo-Ad-DOPE) or biotin-labeled(biot-CMG2-DOPE) probes has any deleterious effect on influenza virus hemagglutinin(HA) receptor specificity, neuraminidase(NA) activity, or replicative ability in vitro. Our data clearly show that neither construct significantly affected influenza virus infectivity or viral affinity to sialyl receptors. Neither construct influenced the NA activities of the influenza viruses tested, except the A/Puerto Rico/8/34(H1N1) strain. Our data indicate that lipid labeling provides a powerful tool to analyze influenza virus infection in vitro. | Natalia A Ilyushina Evgeny S Chernyy Elena Y Korchagina Aleksra S Gambaryan Stephen M Henry Nicolai V Bovin | 2014 | Virologica Sinica2014，29，4： | 2 |
| 5 | Characterization of digestive enzymes in carnivorous ornamental fish,the Asian bony tongue Scleropages formosus(Osteoglossidae)显示文摘 | Natalia Y Hashim R Ali A | 2004 | Aquaculture2004，233，26： | 1 |
| 6 | Prognostic role of mieroRNA-34a expression in colorectal cancer 显示文摘 | Lin Albert Y Kouzminova Natalia B Pollack J | 2014 | ASCO Meeting Abstracts2014，32，3： | 1 |
| 7 | Estimating and fusing quality factors for iris biometric images显示文摘 | Nathan D K Zuo J Y Natalia A S | 2010 | IEEE Transactions on Systems Man and Cybernetics Part A: Systems and Humans2010，40，3： | 1 |
| 8 | Characterization of digestive enzymes in carnivorous ornamental fish,the Asian bony tongue Scleropages formosus(Osteoglossidae)显示文摘 | NATALIA Y HASHIM R ALI A | 2004 | Aquaculture2004，223，： | 1 |
| 9 | Characterization of digestive enzymes in carnivorous ornamental fish,the Asian bony tongue Scleropages formosus (Osteoglossidae)显示文摘 | Natalia Y Hashim R Ali A | 2004 | Aquaculture2004，223，： | 1 |
| 10 | Characterization of digestive enzymes in carnivorous ornamental fish,the Asian bony tongue Scleropages formosus (Osteoglossidae)显示文摘 | Natalia Y Hashim R Ali A | 2004 | Aquaculture2004，223，： | 1 |
| 11 | Isolation of tellurite- and selenite-resistant bacteria from hydrothermal vents of the Juan de Fuca Ridge in the Pacific Ocean 显示文摘 | Christopher R Natalia Y Erko S J | 2002 | Applied and Environmental Microbiology2002，68，： | 1 |
| 12 | Characterization of digestive enzymes in a carnivorous ornamental fish,the Asian bony tongue Scleropages form osus(Osteoglossidae)显示文摘 | NATALIA Y HASHIM R ALI A | 2002 | Aquaculture2002，223，： | 1 |
| 13 | High Efficiency Solid-State Sensitized Solar Cell-Based on Submicrometer Rutile TiO2 Nanorodand CH3NH3PbI3 Perovskite Sensitizer显示文摘 | Hui S K Jin W L Natalia Y | 2013 | Nano Lett2013，13，6： | 1 |
| 14 | Characterization of digestive enzymes in carnivorous ornamental fish,the Asian bony tongue Scleropages formosus (Osteoglossidae) 显示文摘 | Natalia Y Hashim R Ali A | 2004 | Aquaculture2004，233，26： | 1 |
| 15 | Functional silk:colored and luminescent显示文摘 | Natalia C T Leng D K Ming Y H | 2012 | Adv Mater2012，24，11： | 1 |
| 16 | Characterization of Digestive Enzymes in a Carnivorous Ornamental fish,the Asian Bony Tongue Scleropages Formosus (Osteoglossidae)显示文摘 | Natalia Y Hashim R Ali A Chong L | 2004 | Aquaculture2004，233，： | 1 |
| 17 | Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells显示文摘BACKGROUND The morbidity and mortality of human immunodeficiency virus(HIV)-infection is often associated with liver disease,which progresses slowly into severe liver dysfunction.There are multiple insults which exacerbate HIV-related liver injury,including HIV-associated dysregulation of lipid metabolism and fat turnover,coinfections with hepatotropic viruses and alcohol abuse.As we reported before,exposure of hepatocytes to HIV and alcohol metabolites causes high oxidative stress,impairs proteasomal and lysosomal functions leading to accumulation of HIV in these cells,which end-ups with apoptotic cell death and finally promotes development of liver fibrosis.AIM To study whether obeticholic acid(OCA)prevents HIV/ethanol metabolisminduced hepatotoxicity and subsequent activation of hepatic stellate cells(HSC)by HIV+apoptotic hepatocyte engulfment.METHODS Huh7.5-CYP(RLW)cells were exposed to HIV and acetaldehyde-generating system(AGS)in the presence or absence of OCA.In the cells,we measured the expression of HIV-related markers:HIVgagRNA-by real-time polymerase chain reaction(PCR),p24-by western blot,HIV DNA-by semi-nested PCR,integrated HIV DNA-by ddPCR.Lysosomal and proteasomal activities were measured using fluorometrically-labeled substrates.For hepatocyte apoptosis,cleaved caspase 3 and cleaved PARP were visualized by western blot and cytokeratin 18-by M30 ELISA-in supernatants.Apoptotic bodies were generated from untreated and HIV-treated RLW cells exposed to UV light.Pro-fibrotic activation of HSC was characterized by Col1A1 and transforming growth factor-βmRNAs,while inflammasome activation-by NLRP3,caspase 1,interleukin(IL)-6,IL-1βmRNA levels.RESULTS In RLW cells,OCA treatment attenuated HIV-AGS-induced accumulation of HIVgagRNA,HIV DNA and p24.OCA suppressed reactive oxygen species production and restored chymotrypsin-like proteasome activity as well as cathepsin B lysosome activity.OCA also decreased HIV-AGS-triggered apoptosis in RLW cells.Exposure of HIV-containing apoptotic hepatocytes to HSC prevented activation of inflammasome and induced pro-fibrotic activation in these cells.CONCLUSION We conclude that by suppressing oxidative stress and restoring proteasomal and lysosomal functions impaired by HIV and ethanol metabolism,OCA decreases accumulation of HIV in hepatocytes,leading to down-regulation of apoptosis in these cells.In addition,OCA reverses pro-fibrotic and inflammasome-related activation of HSC triggered by engulfment of HIV-containing apoptotic hepatocytes,potentially contributing to suppression of liver fibrosis development. | Moses New-Aaron Murali Ganesan Raghubendra Singh Dagur Kusum K Kharbanda Larisa Y Poluektova Natalia A Osna | 2020 | World Journal of Hepatology2020，12，11： | 1 |
| 18 | Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection 显示文摘 | Natalia N D Sally U Y | 2000 | Journal of Chromatography B2000，744，1： | 1 |
| 19 | Characterization of digestive enzymes in a carnivorous ornamental fish,the Asian bonytongue Scleropages formosus (Osteoglossidae)显示文摘 | Natalia Y Hashim R Ali A | 2004 | Aquaculture2004，233，14： | 1 |
| 20 | Media Amplification of a Brand Crisis and its Affect on Brand Trust 显示文摘 | Natalia Y Epaminondas K Richard EUiott | 2011 | Journal of Mar- keting Management2011，27，5： | 1 |
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