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| 1 | 盐胁迫下水稻苗期Na^+和K^+吸收与分配规律的初步研究显示文摘选择苗期耐盐性较强的水稻(Oryza sativa)品种(株系)‘AB52’、‘02402’和‘02435’及敏感品种‘日本晴’,在网室周转箱内,设置5 000和8 000 mg·L-1NaCl两种盐处理,以清水为对照,研究盐胁迫下苗期水稻植株不同部位Na+和K+的吸收和分配与品种耐盐性的关系。结果表明,盐胁迫下,株高、绿叶干重和绿叶面积下降,绿叶中的水分含量降低,但茎鞘中的水分含量有所上升。5 000 mg·L-1NaCl胁迫处理10 d,耐盐品种所受的生长影响和叶片伤害程度低于敏感品种,但8 000 mg·L-1NaCl胁迫处理下品种间差异变小。盐胁迫下,水稻植株吸收Na+和置换出K+,但不同器官部位中Na+和K+的区域化分布特征明显,各部位的Na+含量由低到高依次为绿叶、根、茎鞘和枯叶。下部老叶能优先积累较多Na+而枯黄;绿叶吸收Na+相对较少,维持较低的Na+水平,同时保持较高且稳定的K+含量;植株茎鞘通过选择性吸收大量Na+和置换出一部分K+到叶片中,保持绿叶较稳定的K+含量和相对较低的Na+含量,维持较高的K+/Na+比,从而使植株少受盐害。敏感品种‘日本晴’在盐胁迫下绿叶中的Na+含量相对较高,且5 000 mg·L-1NaCl胁迫下绿叶Na+含量已接近高值,与在8 000 mg·L-1NaCl胁迫下差异不大,而耐盐品种绿叶吸收较少的Na+。另一方面,耐盐品种茎鞘的含K+相对较高,在盐胁迫下能吸收容纳较多的Na+,而绿叶中K+/Na+比较高。可以认为,绿叶的K+/Na+比可作为一个衡量耐盐性的相对指标。 | 陈惠哲 Natalia Ladatko 朱德峰 林贤青 张玉屏 孙宗修 | 2007 | 植物生态学报2007，31，5： | 72 |
| 2 | Treatment options for alcoholic and non-alcoholic fatty liver disease: A review显示文摘Alcoholic liver disease(ALD)and non-alcoholic fatty liver disease(NAFLD)are serious health problems worldwide.These two diseases have similar pathological spectra,ranging from simple steatosis to hepatitis to cirrhosis and hepatocellular carcinoma.Although most people with excessive alcohol or calorie intake display abnormal fat accumulation in the liver(simple steatosis),a small percentage develops progressive liver disease.Despite extensive research on understanding the pathophysiology of both these diseases there are still no targeted therapies available.The treatment for ALD remains as it was 50 years ago:abstinence,nutritional support and corticosteroids(or pentoxifylline as an alternative if steroids are contraindicated).As for NAFLD,the treatment modality is mainly directed toward weight loss and co-morbidity management.Therefore,new pathophysiology directed therapies are urgently needed.However,the involvement of several inter-related pathways in the pathogenesis of these diseases suggests that a single therapeutic agent is unlikely to be an effective treatment strategy.Hence,a combination therapy towards multiple targets would eventually be required.In this review,we delineate the treatment options in ALD and NAFLD,including various new targeted therapies that are currently under investigation.We hope that soon we will be having an effective multi-therapeutic regimen for each disease. | Sukhpreet Singh Natalia A Osna Kusum K Kharbanda | 2017 | World Journal of Gastroenterology2017，23，36： | 45 |
| 3 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 4 | 苯甲酰脲类杀虫剂研究进展显示文摘从生物学的观点结合化学的知识介绍了苯甲酰脲类几丁质合成抑制剂类杀虫剂的发展概况、作用机制、致毒方式、毒性和代表性品种,分析了其应用中存在的主要问题及解决途径,并对其发展趋势及前景进行了讨论和对策思考。 | 米娜 王唤 范志金 张海科 Natalia P.Belskaia Vasiliy A.Bakulev | 2009 | 世界农药2009，31，A02： | 30 |
| 5 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 6 | 虚拟货币及其扩展:初步思考显示文摘随着信息加密和网络计算机技术日趋成熟,科技正在推动全球经济的转型变革。虚拟货币的产生在此过程中又显得至关重要。虚拟货币方案在许多情况下便于对等网络交互绕过传统的中央结算所。虚拟货币及其关联技术(特别是基于区块链的分布式账本)正在迅速发展,其未来前景难以预测。虚拟货币带来了许多潜在益处,包括更快速、高效的支付和转账等,并将最终促进普惠金融。一些虚拟货币方案背后的分布式账本技术提供的潜在益处将远超虚拟货币本身。但是,虚拟货币的出现也引发了许多潜在风险,如成为洗钱、恐怖融资、偷税漏税和欺诈等犯罪的工具。虚拟货币虽然目前的规模仍非常有限,对现阶段货币政策实施产生的风险亦甚微,但随着新技术的广泛应用,其对金融稳定产生的影响会日益显现。有关虚拟货币的有效监管对策还处于起步阶段。虚拟货币的在国家层面跨越了不同机构的职责,并在全球范围内操作,其监管难度很大。并且,许多虚拟货币在传统金融系统之外运作,缺乏透明度,其操作过程更难以被监管。各国监管机构已开始着手应对这些挑战且方式各异。需要注意的是,国家主管部门需认真权衡监管方式,既要适当处置风险又不能扼杀创新。为了在国家层面推进发展进程和促进政策的完善,国际层面也应进行更多努力。随着经验的不断积累,可考虑提出国际标准和最优方法,为不同领域的最优监管对策提供指导,从而促进跨辖区的协调。也可在此类标准基础上,为一些领域设立跨国合作和协调的框架。 | 何东 卡尔·哈伯梅尔 罗斯·莱科 郭建伟 郇志坚 Vikram Haksar Yasmin Almeida Mikari Kashima Nadim Kyriakos-Saad Hiroko Oura Tahsin Saadi Sedik Natalia Stetsenko Concepcion Verdugo.Yepes | 2016 | 金融监管研究2016，，4： | 22 |
| 7 | 世界大河水沙通量变化趋势研究(英文)显示文摘河流水沙运动是地球化学循环的重要驱动力.本研究基于全球变化背景下的长序列水沙资料,对4307条世界大河(流域面积≥1000 km^2)水-沙通量的9种变化趋势及其成因进行了系统研究.结果表明,全球24%的大河呈现显著的径流变化,但年入海通量基本保持稳定;40%的大河呈现显著的泥沙通量变化,年入海通量下降20.8%;其中,亚洲大型河流的水沙通量下降趋势及南美亚马逊河的悬移质浓度上升趋势尤为突出.总体上,71%的世界大河径流变化与降水密切相关,而泥沙通量变化受大坝运行和灌溉等人类活动影响较大. | 李莉 倪晋仁 常方 岳遥 Natalia Frolova Dmitry Magritsky Alistair GLBorthwick Philippe Ciais 王易初 郑春苗 Desmond E.Walling | 2020 | Science Bulletin2020，65，1： | 23 |
| 8 | 为 cholangiocarcinoma 的化疗: 更改显示文摘 Cholangiocarcinomas(bile duct cancers) are a heterogeneous group of malignancies arising from the epithelial cells of the intrahepatic,perihilar and extrahepatic bile ducts.Patients diagnosed with cholangiocarcinoma must be evaluated by a multidisciplinary team and be treated with individualized management.First of all,it is very important to define the potential resectability of the tumor because surgery is the main therapeutic option for these patients.Overall,cholangiocarcinomas have a very poor prognosis.The 5 year survival rate is 5%-10%.In cases with a potentially curative surgery,5 year survival rates of 25%-30% are reported.Therefore,it is necessary to increase the cure rate from surgery,exploring the survival benefit of any adjuvant strategy.It is difficult to clarify the role of adjuvant treatment in localized and locally advanced cholangiocarcinomas.There are limited data and the role of adjuvant chemotherapy/chemoradiation in patients with resected biliary tract cancer is poorly defined.The most relevant studies in the adjuvant setting are one from Japan,the well known ESPAC-3 and BILCAP from the United Kingdom and a meta-analysis.We show the results of these trials.According to medical oncology guidelines,postoperative adjuvant therapy is widely recommended for all patients with intrahepatic or extrahepatic cholangiocarcinoma who have microscopically positive resection margins,as well as for those with a complete resection but node-positive disease.Clinical trials are ongoing.The locally advanced cholangiocarcinoma setting includes a heterogeneous mix of patients:(1) patients who have had surgery but with macroscopic residual disease;(2) patients with locally recurrent disease after potentially curative treatment;and(3) patients with locally unresectable disease at presentation.In these patients,surgery is not an option and chemoradiation therapy can prolong overall survival and provide control of symptoms due to local tumor effects.Nowadays,no neoadjuvant therapy can be considered a standard approach for the treatment of patients with cholangiocarcinoma.There are promising results and randomized trials are needed in patients with a metastatic cholangiocarcinoma.In systemic therapy,no single drug or combination has consistently increased median survival beyond the expected 8-12 mo.It is always recommended that patients enrol in clinical trials.Clinical trials have shown that the more standard chemotherapy for a first line regimen of gemcitabine plus cisplatin(or oxaliplatin as a potentially better tolerated agent) is superior to gemcitabine alone.Leucovorinmodulated 5-fluorouracil,capecitabine monotherapy or single agent gemcitabine are reasonable options for patients with a borderline performance status.After progression in patients with an adequate performance status,active regimens that could be considered include gemcitabine plus capecitabine,or erlotinib plus bevacizumab,for second line treatment. | Natalia Ramírez-Merino Santiago Ponce Aix Hernán Cortés-Funes | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 20 |
| 9 | Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy——AKT/m-TOR Pathway and Resistance to Cancer Therapy显示文摘Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. | Liudmila V SPIRINA Irina V KONDAKOVA Natalia V TARASENKO Elena M SLONIMSKAYA Evgeny A USYNIN Alexey K GORBUNOV Zahar A YURMAZOV Svetlana Yu CHIGEVSKAYA | 2018 | 中国肺癌杂志2018，21，1： | 18 |
| 10 | Phylogenetic alpha and beta diversity in tropical tree assemblages along regionalscale environmental gradients in northwest South America显示文摘Aims Environmental gradients are drivers of species diversity;however,we know relatively little about the evolutionary processes underlying these relationships.A potentially powerful approach to studying diversity gradients is to quantify the phylogenetic structure within and between assemblages arrayed along broad spatial and environmental gradients.Here,we evaluate the phylogenetic structure of plant assemblages along an environmental gradient with the expectation that the habitat specialization of entire lineages is an important evolutionary pattern influencing the structure of tree communities along environmental gradients.Methods We evaluated the effect of several environmental variables on the phylogenetic structure of plant assemblages in 145 plots distributed in northwestern South America that cover a broad environmental gradient.The phylogenetic alpha diversity was quantified for each plot and the phylogenetic beta diversity between each pair of plots was also quantified.Both the alpha and beta diversity measures were then related to spatial and environmental gradients in the study system.Important Findings We found that gradients in temperature and potential evapotranspiration have a strong relationship with the phylogenetic alpha diversity in our study system,with phylogenetic overdispersion in low temperatures and phylogenetic clustering at higher temperatures.Further,the phylogenetic beta diversity between two plots increases with an increasing difference in temperature,whereas annual precipitation was not a significant predictor of community phylogenetic turnover.We also found that the phylogenetic structure of the plots in our study system was related to the degree of seasonal flooding and seasonality in precipitation.In particular,more stressful environments such as dry forests and flooded forests showed phylogenetic clustering.Finally,in contrast with previous studies,we find that phylogenetic beta diversity was not strongly related to the spatial distance separating two forest plots,which may be the result of the importance of the three independent mountain ranges in our study system,which generate a high degree of environmental variation over very short distances.In conclusion,we found that environmental gradients are important drivers of both phylogenetic alpha and phylogenetic beta diversities in these forests over spatial distance. | Sebastián González-Caro María Natalia Umaña Esteban Álvarez Pablo R.Stevenson Nathan G.Swenson | 2014 | Journal of Plant Ecology2014，7，2： | 17 |
| 11 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 12 | Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of most common malignancies in the world. Systemic treatments for HCC, particularly for advanced stages, are limited by the drug resistance phenomenon which ultimately leads to therapy failure. Recent studies have indicated an association between drug resistance and the existence of the cancer stem cells (CSCs) as tumor initiating cells. The CSCs are resistant to conventional chemotherapies and might be related to the mechanisms of the ATP Binding Cassette (ABC) transporters and alterations in the CSCs signaling pathways. Therefore, to contribute to the development of new HCC treatments, further information on the characterization of CSCs, the modulation of the ABC transporters expression and function and the signaling pathway involved in the self renewal, initiation and maintenance of the cancer are required. The combination of transporters modulators/inhibitors with molecular targeted therapies may be a potent strategy to block the tumoral progression. This review summarizes the association of CSCs, drug resistance, ABC transporters activities and changes in signaling pathways as a guide for future molecular therapy for HCC. | Caecilia HC Sukowati Natalia Rosso Lory S Crocè Claudio Tiribelli | 2010 | World Journal of Hepatology2010，2，3： | 16 |
| 13 | Aberrant expression of enzymes regulating m^6A mRNA methylation: implication in cancer显示文摘N^6-methyladenosine(m^6 A) is an essential RNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m^6 A methylation has been implicated in the development and maintenance of diverse human cancers. Altered m^6 A levels affect RNA processing, mRNA degradation, and translation of mRNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. Recent studies have reported that the abnormal expression of m^6 A regulatory enzymes affects m^6 A abundance and consequently dysregulates the expression of tumor suppressor genes and oncogenes, including MYC, SOCS2, ADAM19, and PTEN. In this review, we discuss the specific roles of m^6 A missing space 'writers', 'erasers', and 'readers' in normal physiology and how their altered expression promotes tumorigenesis. We also describe the potential of exploiting the aberrant expression of these enzymes for cancer diagnosis, prognosis, and the development of novel therapies. | Natalia Pinello Stephanie Sun Justin Jong-Leong Wong | 2018 | Cancer Biology & Medicine2018，15，4： | 15 |
| 14 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 15 | Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis显示文摘Histone acetylation/deacetylation 是一个动态过程并且在基因规定起一个重要作用。Histone acetylation 动态平衡被 histone acetyltransferases (帽子) 和 deacetylases (HDAC ) 的对手行动调整。植物染色体编码多重帽子和 HDAC。在许多植物开发的一个必要角色处理的 Arabidopsis 帽子基因 AtGCN5/HAG1plays 例如分裂组织功能,房间区别,叶和花的 organogenesis ,并且对象光和寒冷那样的环境条件的回答,在长期的发展开关和短期的可诱导的基因表示的规定显示这顶帽子的一个重要角色。AtGCN5 目标到很多倡导者并且为几 histone H3 离氨酸残余的 acetylation 被要求。到目标倡导者的 AtGCN5 的招募是可能的被和 DNA 有约束力的抄写因素的直接或间接的相互作用或由和 acetylated histone 离氨酸残余的相互作用在目标上调停。在 AtGCN5 和另外的帽子和 HDAC 之间的相互影响被表明控制特定的规章的小径。在光可诱导的基因表示的 AtGCN5 的角色的分析在为 priming 准备染色质承诺建议 AtGCN5 的功能在植物的可诱导的基因激活。 | Caroline Servet Natalia Conde e Silva Dao-Xiu Zhou | 2010 | Molecular Plant2010，3，4： | 14 |
| 16 | Translational approaches: From fatty liver to non-alcoholic steatohepatitis显示文摘Over the past few decades, non-alcoholic fatty liver disease(NAFLD) has become one, if not the most common,cause of chronic liver disease affecting both adults and children. The increasing number of cases at an early age is the most worrying aspect of this pathology, since it provides more time for its evolution. The spectrum of this disease ranges from liver steatosis to steatohepatitis, fibrosis and in some cases, hepatocellular carcinoma. NAFLD may not always be considered a benign disease and hepatologists must be cautious in the presence of fatty liver. This should prompt the use of the available experimental models to understand better the pathogenesis and to develop a rational treatment of a disease that is dangerously increasing. In spite of the growing efforts, the pathogenesis of NAFLD is still poorly understood. In the present article we review the most relevant hypotheses and evidence that account for the progression of NAFLD to non-alcoholic steatohepatitis(NASH) and fibrosis. The available in vitro and in vivo experimental models of NASH are discussed and revised in terms of their validity in translational studies. These studies must be aimed at the discovery of the still unknown triggers or mediators that induce the progression of hepatic inflammation, apoptosis and fibrosis. | Natalia Rosso Norberto C Chavez-Tapia Claudio Tiribelli Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，27： | 14 |
| 17 | Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between显示文摘Pancreatic cancer is a challenging disease for patients, doctors and researchers who for decades have searched for a cure for this deadly malignancy. Although existing mouse models of pancreatic cancer have shed light on the mecha- nistic basis of the neoplastic conversion of the pancreas, their impact in terms of offering new diagnostics and therapeu- tic modalities remains limited. Chronic pancreatitis is an inflammatory disease of the pancreas that is associated with a gradual damage of the organ and an increased risk of developing neoplastic lesions. In this review, we propose that detailed studies of chronic inflammatory processes in the pancreas will provide insights into the evolution of pancreatic cancer. This information may prove useful in the design of effective therapeutic strategies to battle the disease. | Natalia JURA Herbert ARCHER Dafna BAR-SAGI | 2005 | Cell Research2005，15，1： | 13 |
| 18 | Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression显示文摘Hepatotropic viruses induced hepatitis progresses much faster and causes more liver-related health problems in people co-infected with human immunodeficiency virus(HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus(HBV) and hepatitis C virus(HCV) causes significant numbers of non-acquired immune deficiency syndrome(AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals(DAA) and antiretroviral therapy(ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals. | Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2019 | World Journal of Gastroenterology2019，25，4： | 12 |
| 19 | Metabolic and Phenotypic Responses of Greenhouse-Grown Maize Hybrids to Experimentally Controlled Drought Stress显示文摘到象干旱一样的不能生活的压力的改编是农业上的重要获得相关庄稼相似玉米。在在干旱是一个很主导的应力因素的气候的地区种的庄稼的提高的干旱公差的开发因此在植物繁殖起一个必要作用。以前的研究证明玉米收益潜力和提高的压力忍耐是联系特点。在这研究,我们为他们在一个温室实验处理干旱应力的能力分析了六个不同玉米混血儿。我们能从从不同机关与新陈代谢的数据在浇得好的条件下面并且在水限制下面测量的 morphophysiological 参数联合数据。这些不同机关拥有了不同代谢物作文,与显示最可观的 metabolome 变化追随者水缺乏的叶片。虽然我们能在干旱应力下面在代谢物层次显示出一般增加,包括在 TCA 周期的氨基酸,糖,糖白酒,和中介变化,这些变化不在以前基于领域试用数据被指定了为干旱容忍或易受影响的玉米混血儿之间是微分的。这里描述的数据与相当不同的生长源于一个温室实验的事实调节与相比这个领域里的可以解释忍耐为什么组织的天赋不能在这研究被证实。然而,我们能加亮象其层次某些生理的特点地相关很好的代谢物一样显示了保存回答到干旱的几代谢物。 | Sandra Witt Luis Galicia Jan Lisec Jill Cairns Axel Tiessen Jose Luis Araus Natalia Palacios-Rojas Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 12 |
| 20 | 辅助技术有助于葡萄胎的精确诊断及分型显示文摘葡萄胎是妇科病理临床诊断中常见的疾病.区分非葡萄胎水肿性流产与葡萄胎有重要的临床意义,主要因为葡萄胎具有进展为妊娠滋养叶细胞肿瘤的危险,而且涉及患者的临床随访及处置[1-3].由于完全性葡萄胎(18%~29%)进展为妊娠滋养叶细胞肿瘤的危险性远高于部分性葡萄胎(1.0%~5.6%)[1,3],所以葡萄胎的准确分型是非常重要的. | 郑兴征 吴秉铨 Natalia Buza 惠培 | 2015 | 中华病理学杂志2015，44，1： | 12 |
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