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| 1 | Mass mortality of herring eggs associated with a sedimenting diatom bloom 显示文摘 | MORRISON J A NAPIER I R GAMBLE J C | 1991 | IC- ES Journal of Marine Science1991，48，2： | 1 |
| 2 | Structure-function analysis of the presumptive Arabidopsis auxin permease AUXI显示文摘 | SWARUP R KARGUL J MARCHANT A ZADIK D RAHMAN A MILLS R YEMM A MAY S WILLIAMS L MILLNER P ET A L TSURUMI S MOORE I NAPIER R KERR I D BENNETT M J | 2004 | Plant Cell2004，16，11： | 1 |
| 3 | Suprabasal p53 immunoexpression is strongly associated with high grade dysplasia and risk for malignant trasformation in potentially malignant oral lesions from Northern Ireland显示文摘 | Cruz I Napier SS van der Waal I | | 0，，： | 1 |
| 4 | Iron trafficking in the mitochondrion: novel pathways revealed by disease 显示文摘 | NAPIER I PONKA P RICHARDSON D R | 2005 | Blood2005，105，5： | 1 |
| 5 | Rational metabolic engineering of transgenic plants for biosynthesis of omega -3 polyunsaturates 显示文摘 | Graham I A Larson T Napier J A | 2007 | Current Opinion in Biotechnology2007，18，： | 1 |
| 6 | Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neu- rons显示文摘 | Dang V C Napier I A Christie M J | 2009 | J Neurosci2009，29，10： | 1 |
| 7 | Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice显示文摘 | Johnson EE Chieng B Napier I | 2006 | Br J Pharmacol2006，148，： | 1 |
| 8 | Tailoring plant lipid composition : designer oilseeds come of age 显示文摘 | NAPIER A J GRAHAM A I | 2010 | Current Opinion in Plant Biology2010，，3： | 1 |
| 9 | Functional Inferences of Environmental Coccolithovirus Biodiversity显示文摘The cosmopolitan calcifying alga Emiliania huxleyi is one of the most abundant bloom forming coccolithophore species in the oceans and plays an important role in global biogeochemical cycling.Coccolithoviruses are a major cause of coccolithophore bloom termination and have been studied in laboratory,mesocosm and open ocean studies.However,little is known about the dynamic interactions between the host and its viruses,and less is known about the natural diversity and role of functionally important genes within natural coccolithovirus communities.Here,we investigate the temporal and spatial distribution of coccolithoviruses by the use of molecular fingerprinting techniques PCR,DGGE and genomic sequencing.The natural biodiversity of the virus genes encoding the major capsid protein(MCP)and serine palmitoyltransferase(SPT)were analysed in samples obtained from the Atlantic Meridional Transect(AMT),the North Sea and the L4 site in the Western Channel Observatory.We discovered nine new coccolithovirus genotypes across the AMT and L4 site,with the majority of MCP sequences observed at the deep chlorophyll maximum layer of the sampled sites on the transect.We also found four new SPT gene variations in the North Sea and at L4.Their translated fragments and the full protein sequence of SPT from laboratory strains EhV-86 and EhV-99B1 were modelled and revealed that the theoretical fold differs among strains.Variation identified in the structural distance between the two domains of the SPT protein may have an impact on the catalytic capabilities of its active site.In summary,the combined use of‘standard’markers(i.e.MCP),in combination with metabolically relevant markers(i.e.SPT)are useful in the study of the phylogeny and functional biodiversity of coccolithoviruses,and can provide an interesting intracellular insight into the evolution of these viruses and their ability to infect and replicate within their algal hosts. | Jozef I Nissimov Mark Jones Johnathan A Napier Colin B Munn Susan A Kimmance Michael J Allen | 2013 | Virologica Sinica2013，28，5： | 1 |
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