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| 1 | Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats显示文摘AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95;caspase-3 levels, 451.70 ± 68.27 and 216.20 ± 28.17 vs 28.60 ± 6.46, 170.50 ± 32.37 and 166.50 ± 30.95, P < 0.05). CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation. | Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz | 2008 | World Journal of Gastroenterology2008，14，8： | 14 |
| 2 | Tibialis posterior tendon abnormalities in feet with accessory navicular bone and flatfoot显示文摘 | Esat Kiter Namik Erdag Vasfi Karatosun Izge Gunal | 1999 | Acta Orthopaedica1999，，6： | 2 |
| 3 | Prognostic Indicators for Patients Undergoing Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma?显示文摘 | Tristan D. Yan BSc (Med) MBBS Erwin A. Brun MD Carlos A. Cerruto MD Namik Haveric MD David Chang MS Paul H. Sugarbaker MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 4 | Performance analysis of individual blade pitch control of offshore wind turbines on two floating platforms显示文摘 | H. Namik K. Stol | 2010 | Mechatronics2010，，4： | 2 |
| 5 | Evaluation of penile hemodynamic status and adjustment of treatment alternatives in Peyronie's disease显示文摘Aim:Erectile dysfunction may be observed in up to 80%of patients with Peyronis's disease.An objective evaluation of the erectile function is attempted to work out in patients with Peyronie's disease.Methods:Penile deformity,sexual function and penile vascular status were analyzed in 123patients with Peyronis's disease,who had not received any pertinent treatment.Results:Penile edformity,palpable plaque and pain on erection were seen in112(91%),97(78.8%)and27(21.9%)of the123patients,respectively.Of the 76patients evaluated by color Doppler ultrasounography,veno-occlusive dysfunction as the vascular component for erectile dysfunction was found in 17(22.3%),arterial insufficiency in10(13.1%)and a mixed picture in 23(30.2%).Conclusion:The documentation of penile erectile function and the determination of the vascular status using color Doppler ultrasonography can guide the appropriate therapeutic choice. | Tibet Erdogru Murat Savas Namik Yilmaz Mustafa Faruk Usta Turker Koksal Mutlu Ates Mehmet Baykara | 2002 | Asian Journal of Andrology2002，4，3： | 2 |
| 6 | A 32-KB standard CMOS antifnse one-time programmable ROM embedded in a 16-bit microcontroller显示文摘 | CHAHK YUNIH KIMJB SOBC CHUNKH NAMIK LEE K R | 2006 | IEEE Journal of Solid-State Circuits2006，41，9： | 1 |
| 7 | Performance analysis of individual blade pitch control of offshore wind turbines on two floa- ting platforms 显示文摘 | NAMIK H STOL K | 2011 | Mechatronics2011，21，4： | 1 |
| 8 | Ultrabroad-band Raman amplifierspumped and gain equalized by wavelength-division-multiplexed high-power laser diodes显示文摘 | Namik S Emori Y | 2001 | IEEE Journal on Selected Topics in Quantum Electronics2001，7，1： | 1 |
| 9 | Pore volume and surface area of the carboniferous coals from the Zonguldak basin ( NW Turkey) and their variations with rank and maceral composition 显示文摘 | Gulbin Gilrdal M Namik Yaliin | 2001 | Int J Coal Geol2001，48，12： | 1 |
| 10 | High pressure grinding rolls(HPGR) applications in the cement industry显示文摘 | NAMIK A A LEVENT E HAKAN B | 2006 | Minerals Engineering2006，19，2： | 1 |
| 11 | Higll pressure grinding rolls (HPGR) applications in the cement industry显示文摘 | Namik A A Levent E Hakan B | 2006 | Minerals Engi- neering2006，19，2： | 1 |
| 12 | Expulsion of oil from petroleum source rocks: inferences from pyrolysis of samples of unconventional grain size显示文摘 | Namik Yalcin M Mann Ulrich | 1998 | Organic Geochemistry1998，29，13： | 1 |
| 13 | Design and analysis of remote center of compliance structures显示文摘 | NAMIK C HARVEY L | 2003 | Journal of Robotic Systems2003，20，8： | 1 |
| 14 | Individual Blade Pitch Control of Floating Offshore Wind Turbines 显示文摘 | Namik H Stol K | 2010 | Wind Energy2010，13，1： | 1 |
| 15 | Neutropenic Enterocolitis in Children with Acute Leukemia or Aplastic Anemia显示文摘 | Bulent Alioglu Zekai Avci Figen Ozcay Serdar Arda Namik Ozbek | 2007 | International Journal of Hematology2007，，4： | 1 |
| 16 | Primary Lymphoma of the Central Nervous System: typical and atypical CT and MR imaging appearances 显示文摘 | Namik Erdag Rajeev M Bhorade | 2001 | AJR2001，176，： | 1 |
| 17 | Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromus- cular blockade显示文摘 | Ayse Ozcan Namik Ozcan Handan Gulec | 2012 | Journal of anesthesia2012，26，2： | 1 |
| 18 | Individual Blade Pitch Control of Floating Wind Turbines显示文摘 | Namik H Stol K | 2010 | Wind Energy2010，13，1： | 1 |
| 19 | FEBRILE NEUTROPENIA AS THE PRESENTING SIGN OF APPENDICITIS IN AN ADOLESCENT WITH ACUTE MYELOGENOUS LEUKEMIA显示文摘 | Emel Ozyurek Serdar Arda Servet Ozkiraz Bulent Alioglu Unser Arikan Namik Ozbek | 2006 | Pediatric Hematology-Oncology2006，，3： | 1 |
| 20 | High pressure grinding rells (HPGR) applications in the cement industry 显示文摘 | Namik A A Levent E Hakan B | 2006 | Minerals Engineering2006，19，2： | 1 |
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