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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Evolution of the Social Network of Scientific Collaboration 显示文摘 | Barabasi A L Jeong H Nada Z | 2002 | Physica A-Statistical Me- chanics and Its Applications2002，311，34： | 1 |
| 3 | Peroxyformic acid pulping of palm leaves显示文摘 | A M A Nada H Abou-Yousef S Kamel | 2004 | Journal of Scientific &Industrial Research2004，，63： | 1 |
| 4 | Temporal dynamics of pathogenesis - related metabolites and the:r plausible pathways of induction in potato leaves following inocvlation with Phytophthora infestans 显示文摘 | Abu - Nada Y Kushalappa A C Marshall W D | 2007 | European Journal of Plant Pathology2007，118，4： | 1 |
| 5 | The role and limitations of mammary ductoscopy in management of pathologic nipple discharge显示文摘 | Denewer A EI-Etribi K Nada N | 2008 | Breast J2008，14，5： | 1 |
| 6 | IR and dielectric analysis of cellulose and its derivative 显示文摘 | DAWYM M NADA A A | 2003 | Polymer Plastics Technology and Engineering2003，42，4： | 1 |
| 7 | Infrared spectroscopy of some treated lignins 显示文摘 | NADA A M A YOUSEF M A SHAFFEI K A | 1998 | Polymer Degradation and Stability1998，62，： | 1 |
| 8 | Ion exchange properties of car- boxylated bagasse显示文摘 | Nada A A Hassan M L | 2006 | Journal of Applied Polymer Sci- ence2006，102，2： | 1 |
| 9 | Infrared spectroscopic study of lignins 显示文摘 | NADA A M A EI-SAKHAWY M KAMEL S M | 1998 | Polymer Degradation and Stability1998，60，： | 1 |
| 10 | The role and limitations of mammary ductoscope in management of pathologic nipple discharge显示文摘 | DENEWER A EL-ETRIBI K NADA N | 2008 | The breast journal2008，14，5： | 1 |
| 11 | Supercritical water oxidation for the destruction of municipal excess sludge and alcohol distillery wastewater of molasses显示文摘 | Goto M Nada T Ogata A | 1998 | The Journal of Supercritical Fluids1998，13，13： | 1 |
| 12 | Single-port transumbilical laparoscopic appendectomy:a preliminary multicentric comparative study in 87 patients with acute appendicitis显示文摘 | Vilallonga R Barbaros U Nada A | | 0，，： | 1 |
| 13 | Double common bile duct: A case report显示文摘Double common bile duct (DCBD) is a rare congenital anomaly in which two common bile ducts exist. One usually has normal drainage into the papilla duodeni major and the other usually named accessory common bile duct (ACBD) opens in different parts of upper gastrointestinal tract (stomach, duodenum, ductus pancreaticus or septum). This anomaly is of great importance since it is often associated with biliary lithiasis, choledochal cyst, anomalous pancreaticobiliary junction (APBJ) and upper gastrointestinal tract malignancies. We recently recognized a rare case of DCBD associated with APBJ with lithiasis in better developed common bile duct. The opening site of ACBD was in the pancreatic duct. The anomaly was suspected by transabdominal ultrasonography and finally confirmed by endoscopic retrograde cholangiopancreatography (ERCP) followed by endoscopic sphincterotomy and stone extraction. According to the literature, the existence of DCBD with the opening of ACBD in the pancreatic duct is most frequently associated with APBJ and gallbladder carcinoma. In case of DCBD, the opening site of ACBD is of greatest clinical importance because of its close implications with concomitant pathology. The adequate diagnosis of this rare anomaly is significant since the operative complications may occur in cases with DCBD which is not recognized prior to surgical treatment. | Srdjan P Djuranovic Milenko B Ugljesic Nenad S Mijalkovic Viktorija A Korneti Nada V Kovacevic Tamara M Alempijevic Slaven V Radulovic Dragan V Tomic Milan M Spuran | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 14 | Rat pulmonary circulation after chronic hypoxia:hemodynamic and structural features显示文摘 | RABINOVITCH M GAMBLE W NADAS A S | 1979 | Am J Physiol(Heart Circ Physiol)1979，236，： | 1 |
| 15 | Themal behavior of cellulose and some cellulose derivatives显示文摘 | Nada A M A Hassan M L | 2000 | Polymer Degradation and Stability2000，67，1： | 1 |
| 16 | Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility显示文摘 | Saleh RA Agarwal A Nada EA | 2003 | Fertil Steril2003，79，3： | 1 |
| 17 | Differential adsorption of heavy metal ions by cotton stalk cation exehang-ers containing multiple functional group显示文摘 | Nada A A El-Wakil N A Hassan M L | 2006 | Journal of Applied Polymer Science2006，101，6： | 1 |
| 18 | A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial au- tologous cd34 + cell administration in patients with refractory angina: design of the RENEW study 显示文摘 | Povsic TJ Junge C Nada A | 2013 | Am Heart J2013，165，： | 1 |
| 19 | Dabska tumor (endovascular papillary angioendothelioma) of testis:A case report with brief review of literature显示文摘 | Bhatia A Nada R Kumar Y | 2006 | Diagn Pathol2006，1，： | 1 |
| 20 | Association of particulate matter components with daily mortality and morbidity in urban populations显示文摘 | LIPPMANN M LTO K NADAS A | 2000 | Res Rep Health Eff Inst2000，，95： | 1 |
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