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| 1 | A new fast swelling poly[DAPB-co-DMAAm-co-AASS] superabsorbent hydrogel for removal of anionic dyes from water显示文摘The objective of this research is to utilize a new poly[N,N-diallyl pyrrolidinium bromide-co-N,Ndimethyl acrylamide-co-acrylic acid sodium salt]superabsorbent hydrogel(SAH)for the removal of two anionic dyes,e.g.,Reactive Red 5B(RR5B)and Reactive Orange M2R(ROM2R),from water.The SAH was characterized by swelling in water,FTIR,TGA and SEM.The SAH DDA6showed good swelling property and thermal stability.We have also investigated the parameters affecting dye adsorption such as pH,adsorbent dose,adsorption rate and initial dye concentration.The experimental data were also analyzed by applying the well known Langmuir and Freundlich isotherm models. | Yatin N.Patel Manish P.Patel | 2013 | Chinese Chemical Letters2013，24，11： | 5 |
| 2 | Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies显示文摘Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)pathway.Several important functions are executed by the Hh signaling cascade such as organogenesis,tissue regeneration,and tissue homeostasis,among various others.Considering the multiple functions carried out by this pathway,any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers.In the present review article,we explored a wide range of diseases caused by aberrant Hh signaling,including developmental defects and cancers.Finally,we concluded this mini-review with various treatment strategies for Hh-induced diseases. | Trupti N.Patel Pavan Kumar Dhanyamraju | 2022 | The Journal of Biomedical Research2022，36，1： | 2 |
| 3 | Resistance resonance induced by electron-hole hybridization in a strongly coupled InAs/GaSb/AlSb heterostructure显示文摘 | L.Cooper N.Patel V.Drouot E.Linfield D.Ritchie and M.Pepper | | 0，，19： | 1 |
| 4 | LC-MS/MS assay for olanzapine in human plasma and its application to a bioequivalence study显示文摘This paper describes a selective and sensitive assay for the determination of olanzapine(OLZ)in human plasma based on liquid chromatography-tandem mass spectrometry(LC-MS/MS).The analyte and quetiapine as internal standard(IS)were extracted from 200μL plasma via solid phase extraction on Waters Oasis HLB cartridges.Chromatographic separation was achieved on an ACE 5C18-300 column(100 mm × 4.6 mm,5μm)under isocratic conditions in a run time of 3.5 min.Mass spectrometric detection involved electrospray ionization in the positive ion mode followed by multiple reaction monitoring(MRM)of the transitions at m/z 313/256 for OLZ and m/z 384/253 for the IS.The assay was linear in the range 0.10-40.0 ng/mL with a lower limit of quantitation and limit of detection of 0.10 and 0.012 ng/mL,respectively.Intra-and inter-day precision(as coefficient of variation)and relative recovery were<5.0% and>90%,respectively.The method was succesfully applied to a bioequivalence study of 5 and 10 mg OLZ disintegrating tablets in 40 healthy Indian males with reproducibility by incurred sample reanalysis in the range-7.43 to 8.07%. | Dinesh S.Patel Naveen Sharma Mukesh C.Patel Bhavin N.Patel Pranav S.Shrivastav Mallika Sanyal | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 1 |
| 5 | Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS显示文摘A highly selective and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) assay has been described for the determination of asenapine(ASE) in presence of its inactive metabolites N-desmethyl asenapine(DMA) and asenapine-N-glucuronide(ASG). ASE, and ASE 13C-d3, used as internal standard(IS), were extracted from 300 mL human plasma by a simple and precise liquid-liquid extraction procedure using methyl tert-butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP_(8e)(100 mm×4.6 mm) column using acetonitrile-5.0 mM ammonium acetate-10% formic acid(90:10:0.1, v/v/v) within 4.5 min. Quantitation of ASE was done on a triple quadrupole mass spectrometer equipped with electrospray ionization in the positive mode. The protonated precursor to product ion transitions monitored for ASE and ASE 13C-d3 were m/z 286.1→166.0 and m/z 290.0→166.1, respectively. The limit of detection(LOD) and limit of quantitation(LOQ) of the method were 0.0025 ng/mL and 0.050 ng/mL respectively in a linear concentration range of 0.050–20.0 ng/mL for ASE. The intra-batch and inter-batch precision(% CV) and mean relative recovery across quality control levels were ≤5.8% and 87.3%, respectively. Matrix effect, evaluated as IS-normalized matrix factor, ranged from 1.03 to 1.05. The stability of ASE under different storage conditions was ascertained in presence of the metabolites. The developed method is much simpler, matrix free, rapid and economical compared to the existing methods. The method was successfully used for a bioequivalence study of asenapine in healthy Indian subjects for the first time. | Nirav R Patel Mallika Sanyal Naveen Sharma Dinesh S.Patel Pranav S.Shrivastav Bhavin N.Patel | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 1 |
| 6 | Pd-C powder and thin film catalysts for hydrogen production by hydrolysis of sodium borohydride显示文摘 | N.Patel B.Patton C.Zanchetta R.Fernades G.Guella A.Kale | | 0，，01： | 1 |
| 7 | Electrostatic complementarity of B-cell receptor CDR3s and TP53-mutant amino acids in breast cancer is associated with increased disease-free survival rates显示文摘Breast cancer has long been characterized as a B-cell-related disease with regard to the immune response.For example,data have indicated that B-cell receptor(BCR)recombination read recoveries from breast cancer exome(WXS)files revealed an increased disease-free survival(DFS)rate.1 However,the antigens stimulating the B-cell response have not been well characterized,particularly via immunogenomics analyses.Thus,we evaluated the net charge per residue(NCPR)for CDR3s,for BCRs expressed on tumor-infiltrating lymphocytes(TILs),to assess its electrostatic complementarity with TP53-mutant amino acids(AAs),because the CDR3 loop domain is the most important part of the BCR polypeptide for antigen-binding specificity. | Juan F.Arturo Boris I.Chobrutskiy Michelle Yeagley Dhruv N.Patel Shayan Falasiri Jay S.Patel George Blanck | 2020 | Cellular & Molecular Immunology2020，17，7： | 0 |
| 8 | Synthesis of some novel divalent transition metal complexes as antimicrobials显示文摘转变金属建筑群的一个新奇系列从 5- 的反应被综合了((有转变金属盐的 3-(methylthio )-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-ylamino)methyl)quinolin-8-ol。这些混合物的结构被元素、光谱的分析阐明了。而且,混合物被屏蔽为在对代表性的面板的 vitro 抗菌剂活动二克积极并且二个克否定的细菌和真菌的二紧张。各种各样的混合物表演有势力对测试有机体的禁止的行动。 | Kaushal K.Oza Paresh N.Patel Hasmukh S.Patel | 2011 | Chinese Chemical Letters2011，22，8： | 0 |
| 9 | Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl)-quinolin-8-ol and its metal complexes显示文摘A novel 5-((4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol(HTPSMQol) was synthesized by optimized reaction of 4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)aniline with 5-chloromethyl-8-hydroxy-quinoline hydrochloride(CMHQ).Also complexes of HTPSMQol were prepared by using various M(Ⅱ) metal salts.All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms.The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin. | Paresh N.Patel Khyati D.Patel Hasmukh S.Patel | 2011 | Chinese Chemical Letters2011，22，11： | 0 |
| 10 | Melanoma therapeutics: a literature review显示文摘Melanoma is a relentless type of skin cancer which involves myriad signaling pathways which regulate many cellular processes.This makes melanoma difficult to treat,especially when identified late.At present,therapeutics include chemotherapy,surgical resection,biochemotherapy,immunotherapy,photodynamic and targeted approaches.These interventions are usually administered as either a single-drug or in combination,based on tumor location,stage,and patients'overall health condition.However,treatment efficacy generally decreases as patients develop treatment resistance.Genetic profiling of melanocytes and the discovery of novel molecular factors involved in the pathogenesis of melanoma have helped to identify new therapeutic targets.In this literature review,we examine several newly approved therapies,and briefly describe several therapies being assessed for melanoma.The goal is to provide a comprehensive overview of recent developments and to consider future directions in the field of melanoma. | Pavan Kumar Dhanyamraju Trupti N.Patel | 2022 | The Journal of Biomedical Research2022，36，2： | 0 |
| 11 | Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study显示文摘A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry(LC–MS/MS) assay has been developed for the simultaneous determination of doxepin(Dox) and its pharmacologically active metabolite, nordoxepin(NDox) in human plasma. The analytes and their internal standards(IS)were extracted from 500 m L of human plasma by liquid-liquid extraction using methyl tert-butyl ether.Chromatographic separation was achieved on Hypurity C8 column(100 mm ? 4.6 mm, 5 mm) using a mixture of acetonitrile-methanol(95:5, v/v) and 2.0 mM ammonium formate in 93:7(v/v) ratio. Detection was accomplished by tandem mass spectrometry in the positive ionization and multiple reaction monitoring acquisition mode. The protonated precursor to product ion transitions studied for Dox, NDox,and their corresponding ISs, propranolol and desipramine, were m/z 280.1-107.0, 266.0-107.0,260.1-116.1 and 267.1-72.1, respectively. A linear dynamic range of 15.0–3900 pg/mL for Dox and 5.00–1300 pg/mL for NDox was established with mean correlation coefficient(r2) of 0.9991 and 0.9993, respectively. The extraction recovery ranged from 86.6%–90.4% and 88.0%–99.1% for Dox and NDox, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was r 8.3% for both the analytes. Stability evaluated under different storage conditions showed no evidence of degradation and the % change in stability samples compared to nominal concentration ranged from 4.7% to12.3%. The method was successfully applied to a bioequivalence study of 6 mg doxepin hydrochloride orally disintegrating tablet in 41 healthy Indian subjects under fasting and fed conditions. | Nirav P.Patel Mallika Sanyal Naveen Sharma Dinesh S.Patel Pranav S.Shrivastav Bhavin N.Patel | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 0 |
| 12 | Comparing the transmission potential from sequence and surveillance data of 2009 North American influenza pandemic waves显示文摘Technological advancements in phylodynamic modeling coupled with the accessibility of real-time pathogen genetic data are increasingly important for understanding the infectious disease transmission dynamics.In this study,we compare the transmission potentials of North American influenza A(H1N1)pdm09 derived from sequence data to that derived from surveillance data.The impact of the choice of tree-priors,informative epidemiological priors,and evolutionary parameters on the transmission potential estimation is evaluated.North American Influenza A(H1N1)pdm09 hemagglutinin(HA)gene sequences are analyzed using the coalescent and birth-death tree prior models to estimate the basic reproduction number(R_(0)).Epidemiological priors gathered from published literature are used to simulate the birth-death skyline models.Path-sampling marginal likelihood estimation is conducted to assess model fit.A bibliographic search to gather surveillancebased R_(0)values were consistently lower(mean≤1.2)when estimated by coalescent models than by the birth-death models with informative priors on the duration of infectiousness(mean≥1.3 to≤2.88 days).The user-defined informative priors for use in the birth-death model shift the directionality of epidemiological and evolutionary parameters compared to non-informative estimates.While there was no certain impact of clock rate and tree height on the R_(0)estimation,an opposite relationship was observed between coalescent and birth-death tree priors.There was no significant difference(p=0.46)between the birth-death model and surveillance R0 estimates.This study concludes that treeprior methodological differences may have a substantial impact on the transmission potential estimation as well as the evolutionary parameters.The study also reports a consensus between the sequence-based R_(0)estimation and surveillanceased R_(0)stimates.Altogether,these outcomes shed light on the potential role of phylodynamic modeling to augment existing surveillance and epidemiological activities to better assess and respond to emerging infectious diseases. | Venkata R.Duvvuri Joseph T.Hicks Lambodhar Damodaran Martin Grunnill Thomas Braukmann Jianhong Wu Jonathan B.Gubbay Samir N.Patel Justin Bahl | 2023 | Infectious Disease Modelling2023，8，1： | 0 |
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