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| 1 | Competition between human cells by entosis显示文摘人的癌由被知道为营养素和生长因素间接地竞争的肿瘤房间的复杂混合物组成。肿瘤房间是否能也直接竞争,例如由对手的消除,不被知道。这里,我们证明人的房间能直接由称为 entosis 的吞没的机制竞争。由 entosis,当时,房间被吞没,或吃活,并且随后经历房间死亡。我们发现吞没的身份(“ winner”) 并且吞没(“ loser”) 房间被 RhoA 和肌动球朊控制的机械 deformability 支配,有高 deformability 的肿瘤房间在此优先地吞没并且 outcompete 有在异构的人口的低 deformability 的附近的房间。我们进一步发现那激活的 Kras 并且 Rac 发信号由 downregulating 给予获胜者地位到房间可收缩的肌浆球蛋白,允许最后经历房间死亡的附近的房间的成为主观。最后,我们计算 cell-in-cell 形成的精力风景,表明那一机械在获胜者和输家房间之间微分被要求让 entosis 继续。这些数据在发生在人的肿瘤的哺乳动物的房间定义竞争的机制。 | Qiang Sun Tianzhi Luo Yixin Ren Oliver Florey Senji Shirasawa Takehiko Sasazuki Douglas N Robinson Michael Overholtzer | 2014 | Cell Research2014，24，11： | 8 |
| 2 | GPS(全球定位系统)同步电流差动保护的应用显示文摘介绍数字式电流差动保护在输配电网络中作为主保护的应用情况。讨论电力部门为降低成本而租用电信通道时遇到的问题,分析说明GPS同步数字式电流差动保护如何通过同步数字级(SDH或SONET环)电信网而实现保护的高可靠性。 | S H Richards, S Potts, N Robinson, S Pickering, A Apostolov(Alstom T&D Protection & Control, France) | 2002 | 国际电力2002，6，3： | 8 |
| 3 | Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease:A systematic review and meta-analysis显示文摘Background Cardiorespiratory fitness(CRF)is inversely associated with mortality in apparently healthy subjects and in some clinical populations,but evidence for the association between CRF and all-cause and/or cardiovascular disease(CVD)mortality in patients with established CVD is lacking.This study aimed to quantify this association.Methods We searched for prospective cohort studies that measured CRF with cardiopulmonary exercise testing in patients with CVD and that examined all-cause and CVD mortality with at least 6 months of follow-up.Pooled hazard ratios(HRs)were calculated using random-effect inverse-variance analyses.Results Data were obtained from 21 studies and included 159,352 patients diagnosed with CVD(38.1%female).Pooled HRs for all-cause and CVD mortality comparing the highest vs.lowest category of CRF were 0.42(95%confidence interval(95%CI):0.28–0.61)and 0.27(95%CI:0.16–0.48),respectively.Pooled HRs per 1 metabolic equivalent(1-MET)increment were significant for all-cause mortality(HR=0.81;95%CI:0.74–0.88)but not for CVD mortality(HR=0.75;95%CI:0.48–1.18).Coronary artery disease patients with high CRF had a lower risk of all-cause mortality(HR=0.32;95%CI:0.26–0.41)than did their unfit counterparts.Each 1-MET increase was associated with lower all-cause mortality risk among coronary artery disease patients(HR=0.83;95%CI:0.76–0.91)but not lower among those with heart failure(HR=0.69;95%CI:0.36–1.32).Conclusion A better CRF was associated with lower risk of all-cause mortality and CVD.This study supports the use of CRF as a powerful predictor of mortality in this population. | Yasmin Ezzatvar MikelIzquierdo Julio Núñez Joaquín Calatayud Robinson Ramírez-Vélez Antonio García-Hermoso | 2021 | Journal of Sport and Health Science2021，10，6： | 6 |
| 4 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 5 | A Ferric Chelate Reductase for Iron Uptake from Soils显示文摘 | | 1999 | Nature1999，，397： | 1 |
| 6 | Arsenic hyperaccumulation by aquatic macrophytes in the Taupo Volcanic Zone, New Zealand 显示文摘 | ROBINSON B KIM N MARCHETTI M | 2006 | Environmental and Experimental Botany2006，58，123： | 1 |
| 7 | De in-vitro generation of dendritic cells from blast cells acute leukemia 显示文摘 | ROBINSON N S P JAJU R | 1998 | Br J Haematol1998，103，： | 1 |
| 8 | Failure analysis of three Si3N4 balls used in hybrid bearings显示文摘 | O'Brien M J Presser N Robinson E Y | | 0，，10： | 1 |
| 9 | Postoperative delirium in the elderly:risk factors and outcomes显示文摘 | ROBINSON THOMAS N RAEBURN | 2009 | Annals of Surgery2009，249，1： | 1 |
| 10 | Dental management of patients irradiated for head and neck cancer显示文摘 | BEECH N ROBINSON S PORCEDDU S | 2014 | Australian dental journal2014，59，1： | 1 |
| 11 | The DSCI channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila mel(mogaster显示文摘 | KULKARNI N H YAMAMOTO A H ROBINSON K O et ol | 2002 | Genet- ics2002，161，4： | 1 |
| 12 | Submemed macrophytes and the hydraulic reushhess of a lowland chalkstream显示文摘 | DAWSON F H ROBINSON W N | 1984 | Verhandlung Internationale Vereinigung Limnologie1984，，22： | 1 |
| 13 | Russian Patrimonial Capitalism and the International Financial Crisis显示文摘 | Robinson N | 2011 | Journal of Communist Studies and Transition Politics2011，27，34： | 1 |
| 14 | The place of gold in rapid tests显示文摘 | CHANDLER J GURMIN T ROBINSON N | 2000 | IVD Technology2000，，6： | 1 |
| 15 | A preliminary estimate of organic carbon transport by the Ayeyarwady (Irrawaddy) and Thanlwin (Salween) Rivers of Myanmar显示文摘 | BIRD M ROBINSON R WIN OO N | 2008 | Quaternary International2008，186，1： | 1 |
| 16 | Switchablecharge traps in polymer diodes 显示文摘 | Andersson P Robinson N D Berggren M | 2005 | Adv Mater2005，17，： | 1 |
| 17 | Lipid chemistry of Icelandic hot spring microbial mats显示文摘 | Robinson N Eglinton G | 1990 | Organic Geochemistry1990，15，3： | 1 |
| 18 | IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium显示文摘 | Nguyen T Robinson N Allison SE | 2013 | Placenta2013，34，9： | 1 |
| 19 | Paclitaxel maintenance chemotherapy following intraperitoneal chemotherapy for ovarian cancer 显示文摘 | Robinson WR Davis N Rogers AS | 2008 | Gynecot Cancer2008，18，5： | 1 |
| 20 | Real-world automotive emissions-summary of studies in the Fort McHenry and Tuscarora Mountain Tunnels显示文摘 | Pierson W R Gertler A W Robinson N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
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