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| 1 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 2 | RePizer:a framework for prioritization of software requirements显示文摘标准的软件开发周期很大程度上取决于利益相关方的需求。软件开发全程围绕需求设计和管理。考虑到时间和资源的限制,必须分清哪些是必须首先考虑的高优先级需求。已有的需求排序架构缺少对历史数据的记录,而这些历史数据有助于从类似项目中方便地选取最适合的需求排序技术。本文中,我们提出一种名为Re Pizer的软件需求排序架构,该架构与一种选定的需求排序技术联合使用,可以基于给定标准(如开发成本),为软件需求优先级排序。Re Pizer通过从需求库提取历史数据,为软件需求工程师决策提供协助。此外,Re Pizer提供了对整个项目的全景式视角,以确保对资源的审慎使用。基于Re Pizer架构,采用已有的两种需求排序技术:计划博弈(planning game,PG)和层级分析(analytical hierarchy process,AHP),分别比较各自的预期准确度和易用程度。结果表明,采用计划博弈时,Re Pizer性能更佳。 | Saif Ur Rehman KHAN Sai Peck LEE Mohammad DABBAGH Muhammad TAHIR Muzafar KHAN Muhammad ARIF | 2016 | Frontiers of Information Technology & Electronic Engineering2016，17，8： | 2 |
| 3 | Determinants of Bank Profitability in a Developing Economy:Empirical Evidence from Bangladesh显示文摘 | Sufian Fadzlam Habibullah Muzafar Shah | 2009 | Journal of Business Economics and Management2009，10，3： | 1 |
| 4 | Globalization and bank efficiency nexus: Symbiosis or parasites?显示文摘 | Fadzlan Sufian Muzafar Shah Habibullah | 2012 | Review of Development Finance (-)2012，，3： | 1 |
| 5 | Spider-Net within the N6, PVA and PU Electrospun Nanofiber Mats Using Salt Addition: Novel Strategy in the Electrospinning Process 显示文摘 | Nasser A M Barakata B Muzafar A | 2009 | Polymer2009，50，18： | 1 |
| 6 | Spider-net within the N6, PVA and PU electrospun nanofiber mats using salt addition: Novel strategy in the eleetrospirming process显示文摘 | Nasser A M B Muzafar A K Faheem A S | 2009 | Polymer2009，50，： | 1 |
| 7 | Cloud Computing:A Solution to Geographical Infor-mation Systems(GIS)显示文摘 | MUZAFAR AHMAD BHAT RAZEEF MOHD SHAH BASHIRAHMAD | 2011 | International Journal on ComputerScience and Engineering2011，3，2： | 1 |
| 8 | Private capital flows, stock market and economic growth in developed and developing countries: a comparative analysis 显示文摘 | CHOONGChee- Keong BAHARUMSHAHAhmadZubaidi YUSOP Zulkornain HABIBULLAH Muzafar Shah | 2010 | Japan and the World Economy2010，22，： | 1 |
| 9 | Globalization and bank efiiciency nexus :Symbio- sis or parasites 显示文摘 | Fadzlan Sufian Muzafar Shah HabibuUah | 2012 | Review of Development Finance2012，2，3： | 1 |
| 10 | Navigating the Impact of Globalization on Bank Efficiency in China显示文摘纸在发展中的经济在银行效率上在经济全球化的影响上为第一次提供实验证据。用数据包封分析方法,我们在 20002007 期间计算中国银行部门的效率。实验调查结果建议中国银行部门的无效主要源于规模而非纯技术无效。检验经济全球化的不同部件,我们发现通过更高的贸易流动,文化最近和政治全球化的更大的经济集成在银行效率层次上有重要、积极的影响。实验调查结果建议大写的帐户的自由化(限制) 施加一否定(积极) 对在中国的银行效率层次的影响。 | Fadzlan Sufian Muzafar Shah Habibullah | 2011 | China & World Economy2011，19，5： | 1 |
| 11 | Financial sector consolidation and competition in Malaysia: An application of the Panzar-Rosse method显示文摘 | Fadzlan Sufian Muzafar Shah Habibullah | 2013 | Journal of Economic Studies2013，，3： | 1 |
| 12 | Spider-net within the N6,PVA and PU electrospun nanofiber mats using saltaddition:novel strategy in the electrospinning process显示文摘 | NASSER B A M MUZAFAR A K FAHEEM A S | 2009 | Polymer2009，，50： | 1 |
| 13 | Electronic characterization and photocatalytic properties of TiO2/CdO electrospun nanofibers显示文摘 | Muzafar A. Kanjwal Nasser A. M. Barakat Faheem A. Sheikh Hak Yong Kim | 2010 | Journal of Materials Science2010，，5： | 1 |
| 14 | Azali,Evaluating a credit guarantee agency in a developing economy:a non-parametric approach显示文摘 | Hway-Boon Ong Muzafar Shah Habibullah Alias Radma M | 2003 | International Journal of Social Economics2003，30，2： | 1 |
| 15 | Cloud Com- puting: a Solution to Geographical Information Systems (GIS) 显示文摘 | MUZAFAR A B RAZEEF M S BASHIR A | 2011 | International Journal on Computer Science and Engineering2011，3，2： | 1 |
| 16 | Evaluating a credit guarantee agency in a developing economy: a non-parametric approach显示文摘 | Hway-Boon Ong Muzafar Shah Habibullah Alias Radam M. Azali | 2003 | International Journal of Social Economics2003，，1： | 1 |
| 17 | Fiscal Policy, Institutions and Economic Growth in Asian Economies:Evidence from the Pedronis Cointe- gration Approach 显示文摘 | Hussin Abdullah Muzafar S H Ahmad Z B | 2008 | International Journal of Business and Management (UBM)2008，3，4： | 1 |
| 18 | Azali,Evaluating a credit guarantee agency in a developing economy:a nonparametric approach显示文摘 | Hway-Boon Ong Muzafar Shah Habibullah Alias Radma M | 2003 | International Journal of Social Economics2003，30，2： | 1 |
| 19 | Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsufpn0pxkb0bu6nqo.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation of co-authors Dr.Nissar A.Wani.Dr.Wani is erroneously linked to Sidra Medicine,Doha,Qatar who is actually working at the Department of Biotechnology,School of Life Sciences,Central University of Kashmir,Ganderbal,Jammu&Kashmir,India.Also,the department name'Cancer Research Department'for the first author Ajaz A.Bhat is missing. | Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 20 | Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy显示文摘Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage tumors.Recent clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC.Despite signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most deaths.It is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in HNSCC.Interestingly,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)regimen.This review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor phenotype.Furthermore,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC. | Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
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