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| 1 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 2 | Clinical applications of feature-tracking cardiac magnetic resonance imaging显示文摘Cardiovascular diseases represent the leading cause of mortality and morbidity in the western world. Assessment of cardiac function is pivotal for early diag-nosis of primitive myocardial disorders, identification of cardiac involvement in systemic diseases, detection of drug-related cardiac toxicity as well as risk stratification and monitor of treatment effects in patients with heart failure of various etiology. Determination of ejection fraction with different imaging modalities currently represents the gold standard for evaluation of cardiac function. However, in the last few years, cardiovascular magnetic resonance feature tracking techniques has emerged as a more accurate tool for quantitative evalu-ation of cardiovascular function with several parameters including strain, strain-rate, torsion and mechanical dispersion. This imaging modality allows precise quantification of ventricular and atrial mechanics by directly evaluating myocardial fiber deformation. The purpose of this article is to review the basic principles, current clinical applications and future perspectives of cardiovascular magnetic resonance myocardial feature tracking, highlighting its prognostic implications. | Daniele Muser Simon A Castro Pasquale Santangeli Gaetano Nucifora | 2018 | World Journal of Cardiology2018，10，11： | 4 |
| 3 | Management of ventricular tachycardia storm in patients with structural heart disease显示文摘Electrical storm(ES) is a medical emergency characterized by repetitive episodes of sustained ventriculararrhythmias(VAs) in a limited amount of time(at least 3 within a 24-h period) leading to repeated appropriate implantable cardioverter defibrillator therapies. The occurrence of ES represents a major turning point in the natural history of patients with structural heart disease being associated with poor short-and longterm survival particularly in those with compromised left ventricular ejection fraction(LVEF) that can develop hemodynamic decompensation and multi-organ failure. Management of ES is challenging with limited available evidence coming from small retrospective series and a substantial lack of randomized-controlled trials. In general, a multidisciplinary approach including medical therapies such as anti-arrhythmic drugs, sedation, as well as interventional approaches like catheter ablation, may be required. Accurate patient risk stratification at admission for ES is pivotal and should take into account hemodynamic tolerability of VAs as well as comorbidities like low LVEF, advanced NYHA class and chronic pulmonary disease. In high risk patients, prophylactic mechanical circulatory support with left ventricular assistance devices or extracorporeal membrane oxygenation should be considered as bridge to ablation and recovery. In the present manuscript we review the available strategies for management of ES and the evidence supporting them. | Daniele Muser Pasquale Santangeli Jackson J Liang | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 4 | Lactate inmase and oxygen desaturation in mitochoudrial disorders - evaluation of two diagnostic screening protocols 显示文摘 | Hanisch F Mtiller T Muser A | 2006 | J Neurol2006，253，4： | 1 |
| 5 | Assessment of pelvis and upper leg injury risk in car-pedestrian collisions: comparison of accident statistics,impactor tests and a human body finite element model显示文摘 | Snedeker JG Muser MH Walz FH | 2003 | Stapp Car Crash J2003，47，： | 1 |
| 6 | Microstructuralinsight into pedestrian pelvic fracture as assessed by high-resolution computed tomography显示文摘 | Snedeker JG Walz FH Muser MH | 2006 | J Biomech2006，39，14： | 1 |
| 7 | Adsorbed layers and the origin of static friction 显示文摘 | He G Muser M H Robbins M O | 1999 | Science1999，284，5420： | 1 |
| 8 | Simple microseopic theory of Amontons' s laws for static friction 显示文摘 | Muser M H Wenning L Robbins M O | 2001 | Physical Review Letters2001，86，7： | 1 |
| 9 | Partitioning of bronchopulmonary carcinoids in two different prognostic categories by Ki-67 Score 显示文摘 | Grimaldi F Muser D Beltrami CA | 2011 | Frontiers In Endocrinology2011，2，： | 1 |
| 10 | Optimized restraint systems for low mass vehicles 显示文摘 | Muser M H Krabbel G Utzinger U | 1996 | SAE 962435 Journal of Passenger Cars1996，105，： | 1 |
| 11 | Assessment of Pelvis and Upper Leg Injury Risk in Car-pedestrian Collisions: Comparison of Accident Statistics, Impactor Tests and a Human Body Finite Element Model显示文摘 | Snedeker J G Muser M H Walz F H | 2003 | Stapp Car Crash J2003，47，： | 1 |
| 12 | Conditions for static fric tion between flat crystalline surfaces显示文摘 | Muser M H Robbins M O | 2000 | Physical Re view B2000，61，3： | 1 |
| 13 | Simple micro- scopic theory of Amontons's laws for static friction 显示文摘 | Muser M H Wenning L Robbins M O | 2001 | Physical Review Letters2001，86，7： | 1 |
| 14 | Low-density lipoprotein size and subclasses are markers of clinically apparent and non-apparent atherosclerosis in type 2 diabetes 显示文摘 | Kaspar Berneis Christina Jeanneret Jurgen Muser | 2005 | Metabolism2005，54，2： | 1 |
| 15 | Assessment ofpelvis and upper leg injury risk in car-pedestrian collisions:comparison of accident statistics,impactor tests and a humanbody finite element model显示文摘 | SNEDEKER J G MUSER M H WALZ F H | 2003 | Stapp Car Crash J2003，47，： | 1 |
| 16 | Low-density lipoprotein size and subclasses are markers of clinically apparent and non-apparent atherosclerosis in type 2 diabetes显示文摘 | Berneis K Jeanneret C Muser J | | 0，，： | 1 |
| 17 | Economic Impact of Psychiatric Re- lapse and Recidivism among Adults with Schizophrenia Recently Re- leased fi'om Incarceration: A Markov Model Analysis显示文摘 | Lin I Muser E Munsell M | 2014 | J Mad Econ2014，30，： | 1 |
| 18 | Role of endothelin-1 in renal regu- lation of acid-base equilibrium in acidotic humans 显示文摘 | Pallini A Huher HN Muser J | 2012 | Am J Physiol Renal Physio12012，303，7： | 1 |
| 19 | Disease-specific differences of left ventricular rotational mechanics between cardiac amyloidosis and hypertrophic eardiomyopathy 显示文摘 | Nucifora G Muser D Morocutti G | 2014 | Am J Physiol Heart Circ Phys- io12014，307，： | 1 |
| 20 | Diffusion, elasticity, and shear flow in self-assembled block copolymers:A molecular dynamics study 显示文摘 | Fraser B Denniston C Muser M H | 2005 | J Polym Sci Pol Phys2005，43，： | 1 |
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