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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Hyperbranched polyesteramides-- new dendritic polymers 显示文摘 | Muscat D van Benthem R A T M | 2001 | Top Curr Chem2001，212，： | 1 |
| 3 | The ecology of Craspedacusta sowerbyi Lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | Am Midl Nat1976，95，： | 1 |
| 4 | The ecology of Craspedacusta sowerbii lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | The American Midian Naturalist1976，95，： | 1 |
| 5 | On the predietion of band gaps from hybrid functional theory显示文摘 | Warder A Harrison N M | 2001 | Chemical Physics Letters2001，13，： | 1 |
| 6 | On the prediction of band gaps from hybrid functional theory显示文摘 | Muscat J Wander A Harrison N M | 2001 | Chemical Physics Letters2001，，： | 1 |
| 7 | The ecology of Craspedacusta sowerbyi Lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | Am Midl Nat1976，，95： | 1 |
| 8 | Synthesis of two - dimensional single - crystal berzelianite nanosheets and nanoplates with near - infrared optical absorption 显示文摘 | Deng Z Mansuripur M Muscat A J | 2009 | Journal of Materials Chemistry2009，19，34： | 1 |
| 9 | The NR4A sub- group: immediate early response genes with pleiotro- pic physiological roles显示文摘 | MAXWELL M A MUSCAT G E | 2006 | Nucl Recept Signal2006，4，： | 1 |
| 10 | The NR4A sub group: immediate early response genes with pleiotro- pie physiological roles显示文摘 | MAXWELL M A MUSCAT G E | 2006 | Nucl Recept Signal2006，4，： | 1 |
| 11 | Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma显示文摘 | Muscat A Hawkins C Ashleyd M | 2006 | Cancer2006，107，4： | 1 |
| 12 | 显示文摘 | Deng Z T Mansuripur M Muscat A J | 2009 | Nano Letters2009，9，5： | 1 |
| 13 | Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease 显示文摘 | Pearen M A Muscat G E | 2010 | Mol Endocrinol2010，24，0： | 1 |
| 14 | The ecology of Craspedacusta sowerbyi Lankester, a freshwater hydrozoan 显示文摘 | Acker T S Muscat A M | 1976 | American Midland Naturalist1976，95，： | 1 |
| 15 | Macromolecule formation in low density CF4 plasmas: The influence of H2 显示文摘 | Schabel M J Peterson T W Muscat A J | 2003 | Journal of Applied Physics2003，93，3： | 1 |
| 16 | On the prediction of band gaps from hybrid functional theory显示文摘 | Muscat J Wander A Harrison N M | | 0，，： | 1 |
| 17 | On the prediction of band gaps from hybrid functional theory显示文摘 | MUSCAT J WANDER A HARRISON N M | 2001 | Chem Phys Lett2001，342，34： | 1 |
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